VAX1_DANRE
ID VAX1_DANRE Reviewed; 317 AA.
AC Q801E0; Q6NZV9;
DT 27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 03-AUG-2022, entry version 117.
DE RecName: Full=Ventral anterior homeobox 1;
GN Name=vax1;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, AND DEVELOPMENTAL
RP STAGE.
RX PubMed=12538521; DOI=10.1242/dev.00305;
RA Take-uchi M., Clarke J.D.W., Wilson S.W.;
RT "Hedgehog signalling maintains the optic stalk-retinal interface through
RT the regulation of Vax gene activity.";
RL Development 130:955-968(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Transcription factor that is required for closure of the
CC choroid fissure and together with Vax2 is required for optic nerve
CC differentiation and to limit retinal development to the optic cup.
CC {ECO:0000269|PubMed:12538521}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC -!- TISSUE SPECIFICITY: Expressed in the anterior neural keel and later in
CC the preoptic area and optic stalk. {ECO:0000269|PubMed:12538521}.
CC -!- DEVELOPMENTAL STAGE: First detected in the anterior neural keel at 7
CC somites. By 12 somites, expression is more robust in the medial
CC forebrain and forming eyes. By 16 somites, expression remains within
CC the optic stalk and is predominantly restricted to tissue ventral to
CC the optic stalk and ventral preoptic area. In addition to optic stalk
CC and ventral preoptic area, weakly expressed in the ventral retina near
CC the choroid fissure region by 24 hpf (hours post-fertilization). At 48
CC hpf, expression remains prominent in the ventral preoptic area but is
CC much reduced in the choroid fissure and optic stalk.
CC {ECO:0000269|PubMed:12538521}.
CC -!- SIMILARITY: Belongs to the EMX homeobox family. {ECO:0000305}.
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DR EMBL; AY185348; AAO32143.1; -; mRNA.
DR EMBL; BC065951; AAH65951.2; -; mRNA.
DR RefSeq; NP_919391.2; NM_194410.2.
DR RefSeq; XP_017207092.1; XM_017351603.1.
DR AlphaFoldDB; Q801E0; -.
DR SMR; Q801E0; -.
DR STRING; 7955.ENSDARP00000039283; -.
DR PaxDb; Q801E0; -.
DR GeneID; 373870; -.
DR KEGG; dre:373870; -.
DR CTD; 11023; -.
DR ZFIN; ZDB-GENE-030904-9; vax1.
DR eggNOG; KOG0843; Eukaryota.
DR InParanoid; Q801E0; -.
DR OrthoDB; 1094882at2759; -.
DR PhylomeDB; Q801E0; -.
DR TreeFam; TF319504; -.
DR PRO; PR:Q801E0; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Unplaced.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0007411; P:axon guidance; IEA:InterPro.
DR GO; GO:0007420; P:brain development; IEA:InterPro.
DR GO; GO:0007417; P:central nervous system development; IBA:GO_Central.
DR GO; GO:0061386; P:closure of optic fissure; IMP:ZFIN.
DR GO; GO:1902254; P:negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator; IGI:ZFIN.
DR GO; GO:0030182; P:neuron differentiation; IBA:GO_Central.
DR GO; GO:0021554; P:optic nerve development; IMP:ZFIN.
DR GO; GO:0090259; P:regulation of retinal ganglion cell axon guidance; IMP:ZFIN.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0060041; P:retina development in camera-type eye; IMP:ZFIN.
DR GO; GO:0060042; P:retina morphogenesis in camera-type eye; IGI:ZFIN.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR000047; HTH_motif.
DR InterPro; IPR033020; Vax1.
DR PANTHER; PTHR24339:SF32; PTHR24339:SF32; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00031; HTHREPRESSR.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..317
FT /note="Ventral anterior homeobox 1"
FT /id="PRO_0000240526"
FT DNA_BIND 92..151
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 1..62
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 203..248
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 29..54
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 203..247
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 219
FT /note="R -> S (in Ref. 2; AAH65951)"
FT /evidence="ECO:0000305"
FT CONFLICT 295
FT /note="C -> S (in Ref. 2; AAH65951)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 317 AA; 33940 MW; D7CACAC741C8A4CD CRC64;
MEVRYSQDSE SGMLLKNGLK EGKEGKDSQG SISKTFLKDQ QESFSPSGAV ENCEKSRASS
GDPDYCRRIL VRDAKGSIRE IILPKGLDLD RPKRTRTSFT AEQLYRLEME FQRCQYVVGR
ERTELARQLN LSETQVKVWF QNRRTKQKKD QGKDSELRSV VSETAATCSV LRLLEQGRLL
TPPGLPGLLP HCGSSSLGSA LRGPSLGITA NGGSSSSSRS SAGSSGTAGG SPPLPTVTSS
GTVTGLQGSP PAHGLFSFPM PSLLGSVASR ISSTPLGMAG SLAGNLQELS ARYLCSSAFE
PYSRTNGKEA LDKKVLE
