VAX1_RAT
ID VAX1_RAT Reviewed; 336 AA.
AC Q9JM00;
DT 27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 126.
DE RecName: Full=Ventral anterior homeobox 1;
GN Name=Vax1;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Sprague-Dawley;
RA Bertuzzi S., Mui S.H., Lemke G.;
RT "Rat Vax1: a novel member of the Vax homeobox gene subfamily.";
RL Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Transcription factor that may function in dorsoventral
CC specification of the forebrain. Required for axon guidance and major
CC tract formation in the developing forebrain. May contribute to the
CC differentiation of the neuroretina, pigmented epithelium and optic
CC stalk (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC -!- SIMILARITY: Belongs to the EMX homeobox family. {ECO:0000305}.
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DR EMBL; AF113515; AAF25690.1; -; mRNA.
DR RefSeq; NP_072158.1; NM_022636.1.
DR AlphaFoldDB; Q9JM00; -.
DR SMR; Q9JM00; -.
DR STRING; 10116.ENSRNOP00000011743; -.
DR PhosphoSitePlus; Q9JM00; -.
DR PaxDb; Q9JM00; -.
DR Ensembl; ENSRNOT00000011743; ENSRNOP00000011743; ENSRNOG00000008824.
DR GeneID; 64571; -.
DR KEGG; rno:64571; -.
DR CTD; 11023; -.
DR RGD; 621132; Vax1.
DR eggNOG; KOG0843; Eukaryota.
DR GeneTree; ENSGT00940000161152; -.
DR HOGENOM; CLU_071850_0_0_1; -.
DR InParanoid; Q9JM00; -.
DR OMA; SNPLTMA; -.
DR OrthoDB; 1094882at2759; -.
DR PhylomeDB; Q9JM00; -.
DR TreeFam; TF319504; -.
DR PRO; PR:Q9JM00; -.
DR Proteomes; UP000002494; Chromosome 1.
DR Bgee; ENSRNOG00000008824; Expressed in testis.
DR Genevisible; Q9JM00; RN.
DR GO; GO:0005634; C:nucleus; ISO:RGD.
DR GO; GO:0031490; F:chromatin DNA binding; ISO:RGD.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISO:RGD.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; ISO:RGD.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0001162; F:RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding; ISO:RGD.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:RGD.
DR GO; GO:0048708; P:astrocyte differentiation; IEA:Ensembl.
DR GO; GO:0007411; P:axon guidance; ISO:RGD.
DR GO; GO:0007420; P:brain development; ISO:RGD.
DR GO; GO:0043010; P:camera-type eye development; ISO:RGD.
DR GO; GO:0030154; P:cell differentiation; ISO:RGD.
DR GO; GO:0007417; P:central nervous system development; ISO:RGD.
DR GO; GO:0007406; P:negative regulation of neuroblast proliferation; ISO:RGD.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; ISO:RGD.
DR GO; GO:0007399; P:nervous system development; ISO:RGD.
DR GO; GO:0007405; P:neuroblast proliferation; IEA:Ensembl.
DR GO; GO:0060563; P:neuroepithelial cell differentiation; IEA:Ensembl.
DR GO; GO:0030182; P:neuron differentiation; IBA:GO_Central.
DR GO; GO:0001764; P:neuron migration; ISO:RGD.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0060021; P:roof of mouth development; ISO:RGD.
DR GO; GO:0035914; P:skeletal muscle cell differentiation; ISO:RGD.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR000047; HTH_motif.
DR InterPro; IPR033020; Vax1.
DR PANTHER; PTHR24339:SF32; PTHR24339:SF32; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00031; HTHREPRESSR.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..336
FT /note="Ventral anterior homeobox 1"
FT /id="PRO_0000240524"
FT DNA_BIND 100..159
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 1..39
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 50..69
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 236..267
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 316..336
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..34
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 54..69
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 336 AA; 35012 MW; EB298EC4D72446C0 CRC64;
MFGKTDKMDV RCHSDTEAAR VSKNAHKESR EIKGAEGSLP AAFLKEPQGA FSASGASEDC
NKSKSNSSAD PDYCRRILVR DAKGSIREII LPKGLDLDRP KRTRTSFTAE QLYRLEMEFQ
RCQYVVGRER TELARQLNLS ETQVKVWFQN RRTKQKKDQG KDSELRSVVS ETAATCSVLR
LLEQGRLLSP PGLPALLPPC ATGALGSALR GPSLPALGAG AAAGSAAAAA AAATAPGPAG
AASQHPPAVG GAPGPGPAGP GGLHAGAPTA SHGLFSLPVP SLLGSVASRL SSAPLTMAGS
LAGNLQELSA RYLSSSAFEP YSRTNNKEGA EKKALD
