VAX2A_XENLA
ID VAX2A_XENLA Reviewed; 302 AA.
AC Q9PU20;
DT 27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 104.
DE RecName: Full=Ventral anterior homeobox 2a;
DE AltName: Full=Xvax2;
GN Name=vax2-a; Synonyms=vax2;
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND DEVELOPMENTAL STAGE.
RX PubMed=10485894; DOI=10.1073/pnas.96.19.10729;
RA Barbieri A.M., Lupo G., Bulfone A., Andreazzoli M., Mariani M.,
RA Fougerousse F., Consalez G.G., Borsani G., Beckmann J.S., Barsacchi G.,
RA Ballabio A., Banfi S.;
RT "A homeobox gene, vax2, controls the patterning of the eye dorsoventral
RT axis.";
RL Proc. Natl. Acad. Sci. U.S.A. 96:10729-10734(1999).
RN [2]
RP DEVELOPMENTAL STAGE.
RX PubMed=11118895; DOI=10.1016/s0925-4773(00)00505-0;
RA Liu Y., Lupo G., Marchitiello A., Gestri G., He R.-Q., Banfi S.,
RA Barsacchi G.;
RT "Expression of the Xvax2 gene demarcates presumptive ventral telencephalon
RT and specific visual structures in Xenopus laevis.";
RL Mech. Dev. 100:115-118(2001).
RN [3]
RP FUNCTION.
RX PubMed=21856776; DOI=10.1101/gad.17227011;
RA Vacik T., Stubbs J.L., Lemke G.;
RT "A novel mechanism for the transcriptional regulation of Wnt signaling in
RT development.";
RL Genes Dev. 25:1783-1795(2011).
CC -!- FUNCTION: Transcription factor that may function in dorsoventral
CC specification of the forebrain. Regulates the expression of Wnt
CC signaling antagonists including the expression of a truncated tcf7l2
CC isoform that cannot bind ctnnb1 and acts therefore as a potent
CC dominant-negative Wnt antagonist. Plays a crucial role in eye
CC development and, in particular, in the specification of the ventral
CC optic vesicle. May be a regulator of axial polarization in the retina.
CC {ECO:0000269|PubMed:10485894, ECO:0000269|PubMed:21856776}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC -!- DEVELOPMENTAL STAGE: Expression begins at early neurula stage in the
CC anterior neural plate whereas, at late neurula stage detected in the
CC area which gives rise to ventral telencephalic and diencephalic regions
CC and the eye. After neural tube closure and evagination of the optic
CC vesicles at the early tail-bud stage, expression is specifically
CC restricted to anterior and ventral neural structures, namely the
CC ventral part of the optic vesicles and the ventral regions of the
CC forebrain vesicle. This expression pattern is maintained during
CC subsequent developmental stages. In tadpole embryos, specifically
CC expressed in the ventral regions of both telencephalon and
CC diencephalon. {ECO:0000269|PubMed:10485894,
CC ECO:0000269|PubMed:11118895}.
CC -!- SIMILARITY: Belongs to the EMX homeobox family. {ECO:0000305}.
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DR EMBL; AJ238649; CAB58181.1; -; mRNA.
DR RefSeq; NP_001081712.1; NM_001088243.1.
DR RefSeq; XP_018088768.1; XM_018233279.1.
DR AlphaFoldDB; Q9PU20; -.
DR SMR; Q9PU20; -.
DR PRIDE; Q9PU20; -.
DR GeneID; 398011; -.
DR KEGG; xla:398011; -.
DR CTD; 398011; -.
DR Xenbase; XB-GENE-492927; vax2.L.
DR OMA; CHTELGG; -.
DR OrthoDB; 1094882at2759; -.
DR Proteomes; UP000186698; Chromosome 1L.
DR Bgee; 398011; Expressed in camera-type eye and 2 other tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR GO; GO:0048048; P:embryonic eye morphogenesis; IEA:InterPro.
DR GO; GO:0030900; P:forebrain development; ISS:UniProtKB.
DR GO; GO:0060322; P:head development; IMP:UniProtKB.
DR GO; GO:0007601; P:visual perception; IEA:InterPro.
DR GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR InterPro; IPR000047; HTH_motif.
DR InterPro; IPR033021; Vax2.
DR PANTHER; PTHR24339:SF34; PTHR24339:SF34; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00024; HOMEOBOX.
DR PRINTS; PR00031; HTHREPRESSR.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW Transcription; Transcription regulation; Wnt signaling pathway.
FT CHAIN 1..302
FT /note="Ventral anterior homeobox 2a"
FT /id="PRO_0000240530"
FT DNA_BIND 105..164
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 1..35
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 50..73
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 156..175
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 199..224
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 282..302
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 156..173
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 286..302
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 302 AA; 32749 MW; 988427E89DB79475 CRC64;
MFDQATSMGD GVSEERSPLC GKSATSCSER VRDKGTRADL ECSLRGHSLK DIPVTSTSSP
GSSKEEVQDS QSTGEADYCR RILVRDAKGT IREIVLPKGL DLDRPKRTRT SFTAEQLYRL
ELEFQRCQYV VGRERTELAR QLNLSETQVK VWFQNRRTKQ KKDQSRDSEK RSSSTSESFA
TCNILRLLEQ GRLLSVPAPP NLISSSQNNM GTSSGNGTNL GTSGSTSPII STTPPGAGAF
SLQVPSLAAS SSPRLPTSLC FPGPLLGGLH EIPSGYGLGS SAFEPYTRLD RKDTASSKKS
TS
