ID   VAX2B_XENLA             Reviewed;         294 AA.
AC   Q9IAX9;
DT   27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 94.
DE   RecName: Full=Ventral anterior homeobox 2b;
DE   AltName: Full=Ventral anterior homeobox 3;
GN   Name=vax2-b; Synonyms=vax3;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Bertuzzi S., Mui S.H., Lemke G.;
RT   "Xenopus Vax3: a novel member of the Vax homeobox gene subfamily.";
RL   Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transcription factor that may function in dorsoventral
CC       specification of the forebrain. Regulates the expression of Wnt
CC       signaling antagonists (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC   -!- SIMILARITY: Belongs to the EMX homeobox family. {ECO:0000305}.
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DR   EMBL; AF113517; AAF25692.1; -; mRNA.
DR   RefSeq; NP_001165675.1; NM_001172204.1.
DR   AlphaFoldDB; Q9IAX9; -.
DR   SMR; Q9IAX9; -.
DR   GeneID; 100337605; -.
DR   KEGG; xla:100337605; -.
DR   CTD; 100337605; -.
DR   Xenbase; XB-GENE-6464314; vax2.S.
DR   OMA; SAFEPYN; -.
DR   OrthoDB; 1094882at2759; -.
DR   Proteomes; UP000186698; Chromosome 1S.
DR   Bgee; 100337605; Expressed in camera-type eye and 2 other tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0048048; P:embryonic eye morphogenesis; IEA:InterPro.
DR   GO; GO:0007601; P:visual perception; IEA:InterPro.
DR   GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   InterPro; IPR000047; HTH_motif.
DR   InterPro; IPR033021; Vax2.
DR   PANTHER; PTHR24339:SF34; PTHR24339:SF34; 1.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   PRINTS; PR00031; HTHREPRESSR.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation; Wnt signaling pathway.
FT   CHAIN           1..294
FT                   /note="Ventral anterior homeobox 2b"
FT                   /id="PRO_0000240531"
FT   DNA_BIND        98..157
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          1..27
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          43..65
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          149..168
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          190..223
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          272..294
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        43..62
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        149..166
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        192..223
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        278..294
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   294 AA;  31941 MW;  1AAC6BF523C62376 CRC64;
     MGDGVSEERS PLCGKSATSC SERVRDRGTR ADLECSLRGH SLKDIPVTST SSPGSSKEEV
     LDSQSPGEAD YCRRILVRDA KGTIREIVLP KGLDLDRPKR TRTSFTAEQL YRLELEFQRC
     QYVVGRERTE LARQLNLSET QVKVWFQNRR TKQKKDQSRD SEKRSSSTSE SFATCNILRL
     LEQGRLLSVP APPNMISSQN NMGTSSGNGT SLGTSGSTSP VISTTPPGAG AFSLQVPSLA
     ASSSPRLPTP FYFPGPLLGG LHEIPSGYGL GSSAFEPYTR LDRKDTASGK KSTS