VAX2_DANRE
ID VAX2_DANRE Reviewed; 307 AA.
AC Q801E1;
DT 27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 03-AUG-2022, entry version 130.
DE RecName: Full=Ventral anterior homeobox 2;
GN Name=vax2;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, AND DEVELOPMENTAL
RP STAGE.
RX PubMed=12538521; DOI=10.1242/dev.00305;
RA Take-uchi M., Clarke J.D.W., Wilson S.W.;
RT "Hedgehog signalling maintains the optic stalk-retinal interface through
RT the regulation of Vax gene activity.";
RL Development 130:955-968(2003).
CC -!- FUNCTION: Transcription factor that may function in dorsoventral
CC specification of the forebrain. Required for closure of the choroid
CC fissure and together with vax1 is required for optic nerve
CC differentiation and to limit retinal development to the optic cup.
CC {ECO:0000269|PubMed:12538521}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC -!- TISSUE SPECIFICITY: Expressed in the anterior neural keel and later in
CC the preoptic area, optic stalk and ventral retina.
CC {ECO:0000269|PubMed:12538521}.
CC -!- DEVELOPMENTAL STAGE: By 7 somites, detected in the anterior brain and
CC expression is strong within the optic stalks, preoptic area and
CC telencephalon by 12 somites. By 16 somites, expression in the
CC telencephalon is reduced but that in the preoptic area, optic stalk and
CC ventral retina remains and this pattern of expression is similar at 24
CC hpf (hours post-fertilization). By 48 hpf, expression is restricted to
CC the ventral preoptic area, anterior dorsal hypothalamus and ventral
CC retina. {ECO:0000269|PubMed:12538521}.
CC -!- SIMILARITY: Belongs to the EMX homeobox family. {ECO:0000305}.
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DR EMBL; AY183363; AAO32142.1; -; mRNA.
DR RefSeq; NP_919390.1; NM_194409.1.
DR AlphaFoldDB; Q801E1; -.
DR SMR; Q801E1; -.
DR STRING; 7955.ENSDARP00000076061; -.
DR PaxDb; Q801E1; -.
DR Ensembl; ENSDART00000081620; ENSDARP00000076061; ENSDARG00000058702.
DR GeneID; 373869; -.
DR KEGG; dre:373869; -.
DR CTD; 25806; -.
DR ZFIN; ZDB-GENE-030904-8; vax2.
DR eggNOG; KOG0843; Eukaryota.
DR GeneTree; ENSGT00940000161043; -.
DR HOGENOM; CLU_071850_1_0_1; -.
DR InParanoid; Q801E1; -.
DR OMA; SAFEPYN; -.
DR OrthoDB; 1094882at2759; -.
DR PhylomeDB; Q801E1; -.
DR TreeFam; TF319504; -.
DR PRO; PR:Q801E1; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 7.
DR Bgee; ENSDARG00000058702; Expressed in optic cup and 13 other tissues.
DR ExpressionAtlas; Q801E1; baseline.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0043565; F:sequence-specific DNA binding; IDA:ZFIN.
DR GO; GO:0007417; P:central nervous system development; IBA:GO_Central.
DR GO; GO:0061386; P:closure of optic fissure; IMP:ZFIN.
DR GO; GO:0030900; P:forebrain development; ISS:UniProtKB.
DR GO; GO:1902254; P:negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator; IGI:ZFIN.
DR GO; GO:0030182; P:neuron differentiation; IBA:GO_Central.
DR GO; GO:0021554; P:optic nerve development; IMP:ZFIN.
DR GO; GO:0090259; P:regulation of retinal ganglion cell axon guidance; IMP:ZFIN.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0060041; P:retina development in camera-type eye; IMP:ZFIN.
DR GO; GO:0060042; P:retina morphogenesis in camera-type eye; IGI:ZFIN.
DR GO; GO:0007601; P:visual perception; IEA:InterPro.
DR GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR000047; HTH_motif.
DR InterPro; IPR033021; Vax2.
DR PANTHER; PTHR24339:SF34; PTHR24339:SF34; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00031; HTHREPRESSR.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW Transcription; Transcription regulation; Wnt signaling pathway.
FT CHAIN 1..307
FT /note="Ventral anterior homeobox 2"
FT /id="PRO_0000240529"
FT DNA_BIND 103..162
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 1..70
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 155..175
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 197..254
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 20..37
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 38..64
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 155..171
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 213..251
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 307 AA; 33156 MW; 2F2DD606417A21C2 CRC64;
MFDQATSMGD GIAEDRNHCG SNSLCRDRGR ESKSRTEVGN RSPVQSSTDT PGTSASTPTS
SSEDGHDKLL GVDPDYCRRI LVRDAKGTIR EIVLPKGLDL DRPKRTRTSF TAEQLYRLEL
EFQRCQYVVG RERTELARQL NLSETQVKVW FQNRRTKQKK DQTKDTDKRS SSTSESLATC
NILRLLEQGR LLSVPAPPPN PLLAHPHPGN GSLLGSPSVS TSSGVSSSTT PPGAGSGTFG
LSLSSLSGTP PSPRLGVPPP SLCFTMPLLS GAHHELPSGY GCGTSAFEPY MRIERKDGEL
GGKKTVS
