ID   VAX2_RAT                Reviewed;         292 AA.
AC   Q9JLZ9;
DT   26-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   25-MAY-2022, entry version 109.
DE   RecName: Full=Ventral anterior homeobox 2;
GN   Name=Vax2;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Sprague-Dawley; TISSUE=Schwann cell;
RA   Bertuzzi S., Mui S.H., Lemke G.;
RT   "Rat Vax2: a novel member of the Vax homeobox gene subfamily.";
RL   Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transcription factor that may function in dorsoventral
CC       specification of the forebrain. Regulates the expression of Wnt
CC       signaling antagonists including the expression of a truncated TCF7L2
CC       isoform that cannot bind CTNNB1 and acts therefore as a potent
CC       dominant-negative Wnt antagonist. Plays a crucial role in eye
CC       development and, in particular, in the specification of the ventral
CC       optic vesicle (By similarity). May be a regulator of axial polarization
CC       in the retina. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the EMX homeobox family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AF113516; AAF25691.1; -; mRNA.
DR   RefSeq; NP_072159.1; NM_022637.1.
DR   AlphaFoldDB; Q9JLZ9; -.
DR   SMR; Q9JLZ9; -.
DR   STRING; 10116.ENSRNOP00000018128; -.
DR   PaxDb; Q9JLZ9; -.
DR   PRIDE; Q9JLZ9; -.
DR   GeneID; 64572; -.
DR   KEGG; rno:64572; -.
DR   UCSC; RGD:621133; rat.
DR   CTD; 25806; -.
DR   RGD; 621133; Vax2.
DR   eggNOG; KOG0843; Eukaryota.
DR   InParanoid; Q9JLZ9; -.
DR   OrthoDB; 1094882at2759; -.
DR   PhylomeDB; Q9JLZ9; -.
DR   PRO; PR:Q9JLZ9; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; ISO:RGD.
DR   GO; GO:0005634; C:nucleus; ISO:RGD.
DR   GO; GO:0031490; F:chromatin DNA binding; ISO:RGD.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; ISO:RGD.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0001162; F:RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding; ISO:RGD.
DR   GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:RGD.
DR   GO; GO:0007409; P:axonogenesis; ISO:RGD.
DR   GO; GO:0043010; P:camera-type eye development; ISO:RGD.
DR   GO; GO:0007417; P:central nervous system development; IBA:GO_Central.
DR   GO; GO:0009950; P:dorsal/ventral axis specification; ISO:RGD.
DR   GO; GO:0048048; P:embryonic eye morphogenesis; ISO:RGD.
DR   GO; GO:0030900; P:forebrain development; ISS:UniProtKB.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; ISO:RGD.
DR   GO; GO:0030182; P:neuron differentiation; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0060041; P:retina development in camera-type eye; ISO:RGD.
DR   GO; GO:0007601; P:visual perception; IEA:InterPro.
DR   GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   InterPro; IPR000047; HTH_motif.
DR   InterPro; IPR033021; Vax2.
DR   PANTHER; PTHR24339:SF34; PTHR24339:SF34; 1.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   PRINTS; PR00031; HTHREPRESSR.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation; Wnt signaling pathway.
FT   CHAIN           1..292
FT                   /note="Ventral anterior homeobox 2"
FT                   /id="PRO_0000049353"
FT   DNA_BIND        102..161
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          1..74
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          212..241
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..39
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        42..67
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        218..235
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   292 AA;  31706 MW;  5D1C12BB470682A5 CRC64;
     MGDGGAERDR GPKRREEPGG RSGCRGEHRG AEDLRADTGS TSPREIAGTS ASSPAGSRES
     GGDSDGQQAL GETDHCRRIL VRDAKGTIRE IVLPKGLDLD RPKRTRTSFT AEQLYRLEME
     FQRCQYVVGR ERTELARQLN LSETQVKVWF QNRRTKQKKD QSRDLEKRAS SSAFEAFATS
     NVLRLLEQGR LLSVPRAPSL LALSPGLPGL TAGHRGTSLG DPRNSSQRLN PMPSASASSP
     LPPPLPAVCF SAAPLLDLPA SYKLGSSAFE PYSRLEQQKV GSPGQSDKKA DI