ID   VB05_VACCL              Reviewed;         317 AA.
AC   P24083;
DT   01-MAR-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-1992, sequence version 1.
DT   23-FEB-2022, entry version 83.
DE   RecName: Full=Plaque-size/host range protein;
DE   AltName: Full=Protein B5;
DE   Flags: Precursor;
GN   Name=PS/HR; ORFNames=B5R;
OS   Vaccinia virus (strain Lister) (VACV).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus; Vaccinia virus.
OX   NCBI_TaxID=10252;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=1994573; DOI=10.1016/0042-6822(91)90480-y;
RA   Takahashi-Nishimaki F., Funahashi S., Miki K., Hashizume S., Sugimoto M.;
RT   "Regulation of plaque size and host range by a vaccinia virus gene related
RT   to complement system proteins.";
RL   Virology 181:158-164(1991).
CC   -!- FUNCTION: Regulation of plaque size and host range.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC       membrane protein {ECO:0000305}.
CC   -!- MISCELLANEOUS: The large-plaque-forming LO strain can actively
CC       proliferate in vero (YTV) cells.
CC   -!- SIMILARITY: Belongs to the receptors of complement activation (RCA)
CC       family. {ECO:0000305}.
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DR   EMBL; M55433; AAA48315.1; -; Genomic_DNA.
DR   PIR; A38493; A38493.
DR   SMR; P24083; -.
DR   PRIDE; P24083; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0001848; F:complement binding; IEA:InterPro.
DR   GO; GO:0045916; P:negative regulation of complement activation; IEA:InterPro.
DR   CDD; cd00033; CCP; 3.
DR   InterPro; IPR011176; CCP_VACV_C3/B5.
DR   InterPro; IPR035976; Sushi/SCR/CCP_sf.
DR   InterPro; IPR000436; Sushi_SCR_CCP_dom.
DR   Pfam; PF00084; Sushi; 3.
DR   PIRSF; PIRSF002486; CIP_VAC_C3L; 1.
DR   SMART; SM00032; CCP; 3.
DR   SUPFAM; SSF57535; SSF57535; 3.
DR   PROSITE; PS50923; SUSHI; 3.
PE   3: Inferred from homology;
KW   Disulfide bond; Membrane; Repeat; Signal; Sushi; Transmembrane;
KW   Transmembrane helix.
FT   SIGNAL          1..17
FT                   /evidence="ECO:0000255"
FT   CHAIN           18..317
FT                   /note="Plaque-size/host range protein"
FT                   /id="PRO_0000006018"
FT   TOPO_DOM        18..279
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        280..300
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        301..317
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          19..74
FT                   /note="Sushi 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT   DOMAIN          75..126
FT                   /note="Sushi 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT   DOMAIN          127..184
FT                   /note="Sushi 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT   DOMAIN          185..239
FT                   /note="Sushi 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT   DISULFID        21..61
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT   DISULFID        48..72
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT   DISULFID        76..110
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT   DISULFID        101..125
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT   DISULFID        130..171
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT   DISULFID        157..182
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT   DISULFID        186..225
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT   DISULFID        211..237
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
SQ   SEQUENCE   317 AA;  35086 MW;  F29FF3645E268611 CRC64;
     MKTISVVTLL CVLPAVVYST CTVPTMNNAK LTSTETSFND KQKVTFTCDQ GYHSSDPNAV
     CETDKWKYEN PCKKMCTVSD YVSELYDKPL YEVNSTMTLS CNGETKYFRC EEKNGNTSWN
     DTVTCPNAEC QPLQLEHGSC QPVKEKYSFG EYITINCDVG YEVIGASYIS CTANSWNVIP
     SCQQKCDMPS LSNGLISGST FSIGGVIHLS CKSGFTLTGS PSSTCIDGKW NPILPTCVRS
     NEKFDPVDDG PDDETDLSKL SKDVVQYEQE IESLEATYHI IIVALTIMGV IFLISVIVLV
     CSCDKNNDQY KFHKLLP