ID   VB18_VACCA              Reviewed;         574 AA.
AC   O57263;
DT   07-DEC-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1998, sequence version 1.
DT   23-FEB-2022, entry version 73.
DE   RecName: Full=Ankyrin repeat protein B18;
GN   OrderedLocusNames=MVA186R, ACAM3000_MVA_186;
OS   Vaccinia virus (strain Ankara) (VACV).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus; Vaccinia virus.
OX   NCBI_TaxID=126794;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=9601507; DOI=10.1006/viro.1998.9123;
RA   Antoine G., Scheiflinger F., Dorner F., Falkner F.G.;
RT   "The complete genomic sequence of the modified vaccinia Ankara strain:
RT   comparison with other orthopoxviruses.";
RL   Virology 244:365-396(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate Acambis 3000;
RA   Esposito J.J., Frace M., Sammons S.A., Olsen-Rasmussen M.S., Osborne J.,
RA   Khristova M., Wohlhueter R.M.;
RL   Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; U94848; AAB96556.1; -; Genomic_DNA.
DR   EMBL; AY603355; AAT10582.1; -; Genomic_DNA.
DR   PIR; T37452; T37452.
DR   SMR; O57263; -.
DR   Proteomes; UP000159908; Genome.
DR   Proteomes; UP000172909; Genome.
DR   Gene3D; 1.25.40.20; -; 3.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   InterPro; IPR001810; F-box_dom.
DR   InterPro; IPR018272; PRANC_domain.
DR   Pfam; PF00023; Ank; 2.
DR   Pfam; PF13606; Ank_3; 1.
DR   Pfam; PF09372; PRANC; 1.
DR   SMART; SM00248; ANK; 6.
DR   SUPFAM; SSF48403; SSF48403; 2.
DR   PROSITE; PS50297; ANK_REP_REGION; 1.
DR   PROSITE; PS50088; ANK_REPEAT; 2.
DR   PROSITE; PS50181; FBOX; 1.
PE   4: Predicted;
KW   ANK repeat; Repeat.
FT   CHAIN           1..574
FT                   /note="Ankyrin repeat protein B18"
FT                   /id="PRO_0000067088"
FT   REPEAT          56..87
FT                   /note="ANK 1"
FT   REPEAT          135..164
FT                   /note="ANK 2"
FT   REPEAT          167..213
FT                   /note="ANK 3"
FT   REPEAT          217..249
FT                   /note="ANK 4"
FT   REPEAT          253..285
FT                   /note="ANK 5"
FT   REPEAT          327..356
FT                   /note="ANK 6"
FT   DOMAIN          541..574
FT                   /note="F-box"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00080"
SQ   SEQUENCE   574 AA;  67972 MW;  DA72251F610C34EF CRC64;
     MSRRLIYVLN INRESTHKIQ ENEIYTYFSH CNIDHTSTEL DFVVKNYDLN RRQPVTGYTA
     LHCYLYNNYF TNDVLKILLN HGVDVTMKTS SGRMPVYILL TRCCNISHDV VIDMIDKDKN
     HLSHRDYSNL LLEYIKSRYM LLKEEDIDEN IVSTLLDKGI DPNFKQDGYT ALHYYYLCLA
     HVYKPGECRK PITIKKAKRI ISLFIQHGAN LNALDNCGNT PFHLYLSIEM CNNIHMTKML
     LTFNPNFKIC NNHGLTPILC YITSDYIQHD ILVMLIHHYE TNVGEMPIDE RRIIVFEFIK
     TYSTRPADSI TYLMNRFKNI DIYTRYEGKT LLHVACEYNN THVIDYLIRI NGDINALTDN
     NKHATQLIID NKENSPYTIN CLLYILRYIV DKNVIRSLVD QLPSLPIFDI KSFEKFISYC
     ILLDDTFYNR HVRNRNSKTY RYAFSKYMSF DKYDGIITKC HKETILLKLS TVLDTTLYAV
     LRCHNSKKLR RYLNELKKYN NDKSFKIYSN IMNERYLNVY YKDMYVSKVY DKLFPVFTDK
     NCLLTLLPSE IIYEILYMLT INDLYNISYP PTKV