ID   VB18_VAR67              Reviewed;         574 AA.
AC   P0DSR5; P33824;
DT   16-OCT-2019, integrated into UniProtKB/Swiss-Prot.
DT   16-OCT-2019, sequence version 1.
DT   23-FEB-2022, entry version 7.
DE   RecName: Full=Ankyrin repeat protein B18;
GN   ORFNames=B16R, B18R, B19R;
OS   Variola virus (isolate Human/India/Ind3/1967) (VARV) (Smallpox virus).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus.
OX   NCBI_TaxID=587200;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=1666548;
RA   Shchelkunov S.N., Marennikova S.S., Totmenin A.V., Blinov V.M.,
RA   Chizhikov V.E., Gutorov V.V., Safronov P.F., Pozdnyakov S.G.,
RA   Shelukhina E.M., Gashnikov P.V., Anjaparidze O.G., Sandakhchiev L.S.;
RT   "Creation of a clone library of fragments from the natural variola virus
RT   and study of the structural and functional organization of viral genes from
RT   a circle of hosts.";
RL   Dokl. Akad. Nauk SSSR 321:402-406(1991).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=8384129; DOI=10.1016/0014-5793(93)80041-r;
RA   Shchelkunov S.N., Blinov V.M., Sandakhchiev L.S.;
RT   "Genes of variola and vaccinia viruses necessary to overcome the host
RT   protective mechanisms.";
RL   FEBS Lett. 319:80-83(1993).
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DR   EMBL; X69198; CAA49128.1; -; Genomic_DNA.
DR   EMBL; X67117; CAA47528.1; -; Genomic_DNA.
DR   PIR; A36857; A36857.
DR   RefSeq; NP_042231.1; NC_001611.1.
DR   SMR; P0DSR5; -.
DR   GeneID; 1486549; -.
DR   KEGG; vg:1486549; -.
DR   Proteomes; UP000002060; Genome.
DR   Gene3D; 1.25.40.20; -; 3.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   InterPro; IPR001810; F-box_dom.
DR   InterPro; IPR018272; PRANC_domain.
DR   Pfam; PF00023; Ank; 2.
DR   Pfam; PF13606; Ank_3; 1.
DR   Pfam; PF09372; PRANC; 1.
DR   SMART; SM00248; ANK; 7.
DR   SUPFAM; SSF48403; SSF48403; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 1.
DR   PROSITE; PS50088; ANK_REPEAT; 2.
DR   PROSITE; PS50181; FBOX; 1.
PE   4: Predicted;
KW   ANK repeat; Reference proteome; Repeat.
FT   CHAIN           1..574
FT                   /note="Ankyrin repeat protein B18"
FT                   /id="PRO_0000067091"
FT   REPEAT          56..87
FT                   /note="ANK 1"
FT   REPEAT          135..164
FT                   /note="ANK 2"
FT   REPEAT          167..213
FT                   /note="ANK 3"
FT   REPEAT          217..249
FT                   /note="ANK 4"
FT   REPEAT          253..285
FT                   /note="ANK 5"
FT   REPEAT          327..356
FT                   /note="ANK 6"
FT   DOMAIN          541..574
FT                   /note="F-box"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00080"
SQ   SEQUENCE   574 AA;  68147 MW;  7C3217FD66D9A8F7 CRC64;
     MSRRLIYVLN INRKSTHKIQ ENEIYTYFSY CNIDHTSTEL DFVVKNYDLN RRQPVTGYTA
     LHCYLYNNYF TNDVLKVLLN HGVDVTIKPS SGHMPIYILL TRCCNISHNV VIDMINKDKT
     HLSHKDYSNL LLEYIKSRYM LLKEEDIDEN IVSTLLDKGI DPNFKQDGYT ALHYYYLCLA
     HVYKPGECRK PITIKKAKRI ISLFIQHGAN LNALDNCGNT PFHLYLSIEM CNNIHMTKML
     LTFNPNFEIC NNHGLTPILC YITSDYIQHD ILVMLIHHYE TNVGEMPIDE RRMIVFEFIK
     TYSTRPLDSI TYLMNRFKNI DIHTRYEGKT LLHIACEYNN THVIDYLIRI NGDINALTDN
     NKHAIQLIID NKENSQYTID CLLYILRYIV DKNVIRSLVD QLPYLPIFDI KSFEKFISYC
     ILLDDTFYDR HVQNRDSKTY RYTFSKYISF DKYDSIITKC YEETILLKLS TVLDTTLYSV
     LRCHNSRKLK RYLSVLKKYN NDKSFKIYSN IMNERYLNVY YKDMYVSKVY DKLFPVFTDK
     KCLLTLLPSE IIYEILYMLT IYDLYNISYP PTKV