ID   VC02_VACCC              Reviewed;         512 AA.
AC   P21037;
DT   01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1991, sequence version 1.
DT   23-FEB-2022, entry version 98.
DE   RecName: Full=Kelch repeat protein C2;
GN   ORFNames=C2L;
OS   Vaccinia virus (strain Copenhagen) (VACV).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus; Vaccinia virus.
OX   NCBI_TaxID=10249;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=2219722; DOI=10.1016/0042-6822(90)90294-2;
RA   Goebel S.J., Johnson G.P., Perkus M.E., Davis S.W., Winslow J.P.,
RA   Paoletti E.;
RT   "The complete DNA sequence of vaccinia virus.";
RL   Virology 179:247-266(1990).
RN   [2]
RP   COMPLETE GENOME.
RA   Goebel S.J., Johnson G.P., Perkus M.E., Davis S.W., Winslow J.P.,
RA   Paoletti E.;
RT   "Appendix to 'The complete DNA sequence of vaccinia virus'.";
RL   Virology 179:517-563(1990).
CC   -!- SIMILARITY: Belongs to the poxviruses Kelch family. {ECO:0000305}.
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DR   EMBL; M35027; AAA47999.1; -; Genomic_DNA.
DR   PIR; C42504; C42504.
DR   SMR; P21037; -.
DR   Proteomes; UP000008269; Genome.
DR   Gene3D; 2.120.10.80; -; 1.
DR   Gene3D; 3.30.710.10; -; 1.
DR   InterPro; IPR011705; BACK.
DR   InterPro; IPR000210; BTB/POZ_dom.
DR   InterPro; IPR015915; Kelch-typ_b-propeller.
DR   InterPro; IPR006652; Kelch_1.
DR   InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR   Pfam; PF07707; BACK; 1.
DR   Pfam; PF00651; BTB; 1.
DR   Pfam; PF01344; Kelch_1; 3.
DR   SMART; SM00875; BACK; 1.
DR   SMART; SM00225; BTB; 1.
DR   SMART; SM00612; Kelch; 3.
DR   SUPFAM; SSF117281; SSF117281; 1.
DR   SUPFAM; SSF54695; SSF54695; 1.
DR   PROSITE; PS50097; BTB; 1.
PE   3: Inferred from homology;
KW   Early protein; Kelch repeat; Reference proteome; Repeat.
FT   CHAIN           1..512
FT                   /note="Kelch repeat protein C2"
FT                   /id="PRO_0000119157"
FT   DOMAIN          2..67
FT                   /note="BTB"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
FT   REPEAT          216..261
FT                   /note="Kelch 1"
FT   REPEAT          262..307
FT                   /note="Kelch 2"
FT   REPEAT          309..354
FT                   /note="Kelch 3"
FT   REPEAT          356..403
FT                   /note="Kelch 4"
FT   REPEAT          405..449
FT                   /note="Kelch 5"
FT   REPEAT          452..498
FT                   /note="Kelch 6"
SQ   SEQUENCE   512 AA;  59246 MW;  91F3F94BE7A26E63 CRC64;
     MESVIFSING EIIQVNKEII TASPYNFFKR IQDHHLKDEA IILNGINYHA FESLLDYMRW
     KKINITINNV EMILVAAVII DVPPVVDLCV KTMIHNINST NCIRMFNFSK RYGIKKLYNA
     SMSEIINNIT AVTSDPEFGK LSKDELTTIL SHEDVNVNHE DVTAMILLKW IHKNPNDVDI
     INILHPKFMT NTMRNAISLL GLTISKSTKP VTRNGIKHNI VVIKNSDYIS TITHYSPRTE
     YWTIVGNTDR QFYNANVLHN CLYIIGGMIN NRHVYSVSRV DLETKKWKTV TNMSSLKSEV
     STCVNDGKLY VIGGLEFSIS TGVAEYLKHG TSKWIRLPNL ITPRYSGASV FVNDDIYVMG
     GVYTTYEKYV VLNDVECFTK NRWIKKSPMP RHHSIVYAVE YDGDIYVITG ITHETRNYLY
     KYIVKEDKWI ELYMYFNHVG KMFVCSCGDY ILIIADAKYE YYPKSNTWNL FDMSTRNIEY
     YDMFTKDETP KCNVTHKSLP SFLSNCEKQF LQ