ID   VCCL3_HHV8P             Reviewed;         114 AA.
AC   F5HCJ2;
DT   16-OCT-2013, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   23-FEB-2022, entry version 31.
DE   RecName: Full=Protein vCCL3;
DE   Flags: Precursor;
GN   Name=K4.1;
OS   Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's
OS   sarcoma-associated herpesvirus).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Gammaherpesvirinae; Rhadinovirus.
OX   NCBI_TaxID=868565;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=10400794; DOI=10.1128/jvi.73.8.6953-6963.1999;
RA   Glenn M., Rainbow L., Aurade F., Davison A., Schulz T.F.;
RT   "Identification of a spliced gene from Kaposi's sarcoma-associated
RT   herpesvirus encoding a protein with similarities to latent membrane
RT   proteins 1 and 2A of Epstein-Barr virus.";
RL   J. Virol. 73:6953-6963(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16760382; DOI=10.1099/vir.0.81919-0;
RA   Rezaee S.A.R., Cunningham C., Davison A.J., Blackbourn D.J.;
RT   "Kaposi's sarcoma-associated herpesvirus immune modulation: an overview.";
RL   J. Gen. Virol. 87:1781-1804(2006).
RN   [3]
RP   FUNCTION.
RX   PubMed=17403668; DOI=10.1074/jbc.m702001200;
RA   Luettichau H.R., Johnsen A.H., Jurlander J., Rosenkilde M.M.,
RA   Schwartz T.W.;
RT   "Kaposi sarcoma-associated herpes virus targets the lymphotactin receptor
RT   with both a broad spectrum antagonist vCCL2 and a highly selective and
RT   potent agonist vCCL3.";
RL   J. Biol. Chem. 282:17794-17805(2007).
CC   -!- FUNCTION: Acts as a highly selective agonist for human lymphoactin
CC       receptor XCR1. {ECO:0000269|PubMed:17403668}.
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DR   EMBL; AF148805; ABD28860.1; -; Genomic_DNA.
DR   RefSeq; YP_001129363.1; NC_009333.1.
DR   SMR; F5HCJ2; -.
DR   BioGRID; 1776939; 7.
DR   PRIDE; F5HCJ2; -.
DR   DNASU; 4961436; -.
DR   GeneID; 4961436; -.
DR   KEGG; vg:4961436; -.
DR   Proteomes; UP000000942; Genome.
DR   GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR   GO; GO:0008009; F:chemokine activity; IEA:InterPro.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   InterPro; IPR001811; Chemokine_IL8-like_dom.
DR   InterPro; IPR036048; Interleukin_8-like_sf.
DR   Pfam; PF00048; IL8; 1.
DR   SMART; SM00199; SCY; 1.
DR   SUPFAM; SSF54117; SSF54117; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Signal.
FT   SIGNAL          1..26
FT                   /evidence="ECO:0000255"
FT   CHAIN           27..114
FT                   /note="Protein vCCL3"
FT                   /id="PRO_0000423906"
SQ   SEQUENCE   114 AA;  12678 MW;  E3433382DED5A4D5 CRC64;
     MWSMCWVLRA HLGLLFWVAV IELCAASGPA TIMASDCCEN SLSSARLPPD KLICGWYWTS
     TVYCRQKAVI FVTHSGRKVC GSPAKRRTRL LMEKHTEIPL AKRVALRAGK GLCP