VCL_PISVE
ID VCL_PISVE Reviewed; 545 AA.
AC B4X640;
DT 10-FEB-2021, integrated into UniProtKB/Swiss-Prot.
DT 10-FEB-2021, sequence version 2.
DT 25-MAY-2022, entry version 30.
DE RecName: Full=Vicilin Pis v 3.0101 {ECO:0000305};
DE AltName: Full=7S globulin {ECO:0000303|PubMed:18479490};
DE AltName: Full=7S seed storage protein {ECO:0000305};
DE AltName: Full=7S vicilin-like protein Pis v 3 {ECO:0000303|PubMed:18479490};
DE AltName: Full=Vicilin Pis v 3 {ECO:0000303|PubMed:18479490};
DE AltName: Allergen=Pis v 3.0101 {ECO:0000305};
DE Flags: Precursor;
OS Pistacia vera (Pistachio).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Sapindales; Anacardiaceae; Pistacia.
OX NCBI_TaxID=55513;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, AND
RP ALLERGEN.
RC TISSUE=Seed {ECO:0000303|PubMed:18479490};
RX PubMed=18479490; DOI=10.1111/j.1365-2222.2008.02998.x;
RA Willison L.N., Tawde P., Robotham J.M., Penney R.M., Teuber S.S.,
RA Sathe S.K., Roux K.H.;
RT "Pistachio vicilin, Pis v 3, is immunoglobulin E-reactive and cross-reacts
RT with the homologous cashew allergen, Ana o 1.";
RL Clin. Exp. Allergy 38:1229-1238(2008).
CC -!- FUNCTION: Seed storage protein. {ECO:0000305|PubMed:18479490}.
CC -!- TISSUE SPECIFICITY: Expressed in seed. {ECO:0000269|PubMed:18479490}.
CC -!- DEVELOPMENTAL STAGE: Expressed during seed maturation.
CC {ECO:0000269|PubMed:18479490}.
CC -!- ALLERGEN: Causes an allergic reaction in human. Binds to IgE in 37% of
CC the 19 patients tested allergic to pistachio and/or cashew. Cross-
CC reacts with cashew allergen Ana o 1. {ECO:0000269|PubMed:18479490}.
CC -!- SIMILARITY: Belongs to the 7S seed storage protein family.
CC {ECO:0000305}.
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DR EMBL; EF116865; ABO36677.1; -; mRNA.
DR AlphaFoldDB; B4X640; -.
DR SMR; B4X640; -.
DR Allergome; 3771; Pis v 3.
DR Allergome; 3772; Pis v 3.0101.
DR GO; GO:0045735; F:nutrient reservoir activity; IEA:UniProtKB-KW.
DR Gene3D; 2.60.120.10; -; 2.
DR InterPro; IPR006045; Cupin_1.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR InterPro; IPR011051; RmlC_Cupin_sf.
DR Pfam; PF00190; Cupin_1; 2.
DR SMART; SM00835; Cupin_1; 2.
DR SUPFAM; SSF51182; SSF51182; 2.
PE 1: Evidence at protein level;
KW Allergen; Seed storage protein; Signal; Storage protein.
FT SIGNAL 1..25
FT /evidence="ECO:0000255"
FT CHAIN 26..545
FT /note="Vicilin Pis v 3.0101"
FT /evidence="ECO:0000255"
FT /id="PRO_0000451871"
FT DOMAIN 354..517
FT /note="Cupin type-1 2"
FT /evidence="ECO:0000255"
FT REGION 62..93
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 129..154
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 137..154
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 545 AA; 62496 MW; DD413EA8C164C87B CRC64;
MGSRTKFCLT LFLVSVLILC AGLALAKTDP ELKQCKHQCK VQRQYDEEQK EQCAKGCEKY
YKEKKGREQE EEEEEEWGSG RGRGDEFSTH EPGEKRLSQC MKQCERQDGG QQKQLCRFRC
QEKYKKERRE HSYSRDEEEE EEGDEEQEEE DENPYVFEDE HFTTRVKTEQ GKVVVLPKFT
KRSKLLRGLE KYRLAFLVAN PQAFVVPNHM DADSIFFVSW GRGTITKIRE NKRESMNVKQ
GDIIRIRAGT PFYIVNTDEN EKLYIVKLLQ PVNLPGHYEV FHGPGGENPE SFYRAFSREV
LEAALKTPRD KLEKLFEKQD EGAIVKASKE QIRAMSRRGE GPSIWPFTGK STGTFNLFKK
DPSQSNNYGQ LFESEFKDYP PLQELDIMVS YVNITKGGMS GPFYNSRATK IAIVVSGEGR
LEIACPHLSS SKNSGQEKSG PSYKKLSSSI RTDSVFVVPA GHPFVTVASG NQNLEILCFE
VNAEGNIRYT LAGKKNIIEV MEKEAKELAF KTKGEEVDKV FGKQDEEFFF QGPKWRQHQQ
GRADE
