ID   VCOX_BPP2               Reviewed;          91 AA.
AC   P07695;
DT   01-APR-1988, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1988, sequence version 1.
DT   29-SEP-2021, entry version 75.
DE   RecName: Full=Regulatory protein cox;
GN   Name=cox;
OS   Escherichia phage P2 (Bacteriophage P2).
OC   Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes;
OC   Caudovirales; Myoviridae; Peduovirinae; Peduovirus.
OX   NCBI_TaxID=10679;
OH   NCBI_TaxID=543; Enterobacteriaceae.
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=3475531; DOI=10.1007/bf00330421;
RA   Haggaard-Ljungquist E., Kockum K., Bertani L.E.;
RT   "DNA sequences of bacteriophage P2 early genes cox and B and their
RT   regulatory sites.";
RL   Mol. Gen. Genet. 208:52-56(1987).
RN   [2]
RP   FUNCTION.
RX   PubMed=2826134; DOI=10.1002/j.1460-2075.1987.tb02631.x;
RA   Saha S., Haggaard-Ljungquist E., Nordstroem K.;
RT   "The cox protein of bacteriophage P2 inhibits the formation of the
RT   repressor protein and autoregulates the early operon.";
RL   EMBO J. 6:3191-3199(1987).
CC   -!- FUNCTION: Repressor of the Pc promoter which controls gene C, which
CC       codes for the immunity repressor, and int, whose product promotes the
CC       site-specific recombination over att. {ECO:0000269|PubMed:2826134}.
CC   -!- SIMILARITY: To phage HP1 cox. {ECO:0000305}.
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DR   EMBL; AF063097; AAD03299.1; -; Genomic_DNA.
DR   PIR; S06351; S06351.
DR   RefSeq; NP_046788.1; NC_001895.1.
DR   PDB; 4LHF; X-ray; 2.40 A; A=1-91.
DR   PDBsum; 4LHF; -.
DR   SMR; P07695; -.
DR   GeneID; 1261533; -.
DR   KEGG; vg:1261533; -.
DR   Proteomes; UP000009092; Genome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   Gene3D; 6.10.200.10; -; 1.
DR   InterPro; IPR038147; Cox_sf.
DR   InterPro; IPR019679; Phage_P2_Cox.
DR   Pfam; PF10743; Phage_Cox; 1.
PE   1: Evidence at protein level;
KW   3D-structure; DNA-binding; Early protein; Reference proteome; Repressor;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..91
FT                   /note="Regulatory protein cox"
FT                   /id="PRO_0000165244"
FT   STRAND          10..13
FT                   /evidence="ECO:0007829|PDB:4LHF"
FT   HELIX           14..21
FT                   /evidence="ECO:0007829|PDB:4LHF"
FT   HELIX           25..34
FT                   /evidence="ECO:0007829|PDB:4LHF"
FT   STRAND          39..42
FT                   /evidence="ECO:0007829|PDB:4LHF"
FT   STRAND          54..58
FT                   /evidence="ECO:0007829|PDB:4LHF"
FT   HELIX           59..72
FT                   /evidence="ECO:0007829|PDB:4LHF"
FT   HELIX           75..80
FT                   /evidence="ECO:0007829|PDB:4LHF"
FT   HELIX           81..85
FT                   /evidence="ECO:0007829|PDB:4LHF"
SQ   SEQUENCE   91 AA;  10301 MW;  3191B2DBA46BBF34 CRC64;
     MSKQVTLMTD AIPYQEFAKL IGKSTGAVRR MIDKGKLPVI DMTDPQSASG RAGEYWVYLP
     AWNNGLKLAY ESRPKEIRDG WLMWLGLGEP R