VCR_ARATH
ID VCR_ARATH Reviewed; 1340 AA.
AC Q9LTT9;
DT 11-JUL-2012, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 25-MAY-2022, entry version 137.
DE RecName: Full=Varicose-related protein;
GN Name=VCR; OrderedLocusNames=At3g13290; ORFNames=MDC11.12;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10819329; DOI=10.1093/dnares/7.2.131;
RA Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 3. I. Sequence
RT features of the regions of 4,504,864 bp covered by sixty P1 and TAC
RT clones.";
RL DNA Res. 7:131-135(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-91, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19376835; DOI=10.1104/pp.109.138677;
RA Reiland S., Messerli G., Baerenfaller K., Gerrits B., Endler A.,
RA Grossmann J., Gruissem W., Baginsky S.;
RT "Large-scale Arabidopsis phosphoproteome profiling reveals novel
RT chloroplast kinase substrates and phosphorylation networks.";
RL Plant Physiol. 150:889-903(2009).
CC -!- FUNCTION: As a component of the decapping complex, may play a role in
CC the degradation of mRNAs. {ECO:0000250}.
CC -!- SUBUNIT: Homodimer. Component of the decapping complex (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, P-body {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the WD repeat EDC4 family. {ECO:0000305}.
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DR EMBL; AB024034; BAB02798.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE75329.1; -; Genomic_DNA.
DR RefSeq; NP_187937.2; NM_112174.4.
DR AlphaFoldDB; Q9LTT9; -.
DR STRING; 3702.AT3G13290.1; -.
DR iPTMnet; Q9LTT9; -.
DR PaxDb; Q9LTT9; -.
DR PRIDE; Q9LTT9; -.
DR ProMEX; Q9LTT9; -.
DR ProteomicsDB; 243195; -.
DR EnsemblPlants; AT3G13290.1; AT3G13290.1; AT3G13290.
DR GeneID; 820529; -.
DR Gramene; AT3G13290.1; AT3G13290.1; AT3G13290.
DR KEGG; ath:AT3G13290; -.
DR Araport; AT3G13290; -.
DR TAIR; locus:2088155; AT3G13290.
DR eggNOG; KOG1916; Eukaryota.
DR HOGENOM; CLU_006243_0_0_1; -.
DR InParanoid; Q9LTT9; -.
DR OMA; PGFEKSC; -.
DR OrthoDB; 1424637at2759; -.
DR PhylomeDB; Q9LTT9; -.
DR PRO; PR:Q9LTT9; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q9LTT9; baseline and differential.
DR Genevisible; Q9LTT9; AT.
DR GO; GO:0000932; C:P-body; ISS:UniProtKB.
DR GO; GO:0042803; F:protein homodimerization activity; ISS:UniProtKB.
DR GO; GO:0031087; P:deadenylation-independent decapping of nuclear-transcribed mRNA; ISS:UniProtKB.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; ISS:UniProtKB.
DR GO; GO:0006402; P:mRNA catabolic process; ISS:UniProtKB.
DR GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR Gene3D; 1.10.220.100; -; 1.
DR Gene3D; 2.130.10.10; -; 1.
DR InterPro; IPR045152; EDC4-like.
DR InterPro; IPR044938; EDC4_C.
DR InterPro; IPR032401; EDC4_WD40.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR15598; PTHR15598; 1.
DR Pfam; PF16529; Ge1_WD40; 1.
DR SMART; SM00320; WD40; 2.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 2.
DR PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE 2: Evidence at transcript level;
KW Coiled coil; Cytoplasm; mRNA processing; Phosphoprotein;
KW Reference proteome; Repeat; WD repeat.
FT CHAIN 1..1340
FT /note="Varicose-related protein"
FT /id="PRO_0000418338"
FT REPEAT 219..259
FT /note="WD 1"
FT REPEAT 338..378
FT /note="WD 2"
FT REPEAT 381..427
FT /note="WD 3"
FT DOMAIN 1182..1226
FT /note="LEM"
FT REGION 1..101
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 611..644
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 700..719
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 783..806
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 828..897
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 755..784
FT /evidence="ECO:0000255"
FT COILED 926..946
FT /evidence="ECO:0000255"
FT COILED 1148..1168
FT /evidence="ECO:0000255"
FT COMPBIAS 36..81
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 625..639
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 702..716
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 861..897
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 79
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q9LTT8"
FT MOD_RES 91
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:19376835"
FT MOD_RES 648
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9LTT8"
FT MOD_RES 680
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9LTT8"
SQ SEQUENCE 1340 AA; 145884 MW; FE93F0B01E9088A2 CRC64;
MASSPGNTNP HNPPPFDLGT IFKPSSNPYP PPTGPFLNNQ YNQQLYAPPG IAAQPSPVNQ
TQQDVSSSSS ATNLQPQRTL SYPTPPLNPQ SPRVNHNPGT HILALLNNGG AVANQEPSHH
NEIARAFPGG SGPIHVPSGK MPKGRRLVGE HAVYDVDVRL QGEIQPQLEV TPITKYGSDP
QLVLGRQIAV NKVYICYGLK GGSIRVLNIN TALRSLFRGH SQRVTDMAFF AEDVHLLASV
SLDGKVFVWK ISEGSEGDEQ SQITGKIVVA LQILGEEDTK HPRVCWHCHK QEILVVSIGK
HVLRIDTTKV GRGEVFSAEA PLQCHLDKLI DGVQIVGKHD GEVTDLSMCQ WMTTRLVSSS
VDGTVKIWQD RKTQPLVVLR PHDGLPVNSA IFVTSPERPD HIILITGGPL NREIKIWVSA
GEEGWLLPAD TESWRCTQTL DLKSSTEPQA EKAFFNQVIA LSEAGLLLLA NARRNAIYSV
HLDYGSSPVE TLMDYLSEFT VTMPILSFIG TNDHPEEPFV KVYCVQTLAI QQYTLDLFLC
MPPPRENVGF EKSDSTVSRE ANLVESTLET SGMKPTELPS VGSVPKPSIL VNRSENANML
SFPAGPASAG ITPPAIVPPN GEPKTSGMPS ETSDVDSAYA PSPQLPLSPR LSSKLSGYHT
PVEAFEQVLP HHKLGGKTSS ADYFYVRQTD DVGGRNLDVS SVEENCRSKD TNVTPDDDVS
GIRSPSAFFK QPTHLVTPSE ILMGVSSTEA SITTEDKRDR DANIEEVNND ARGLEVELKE
VGEAQTSQNG EINYHETTEN HTSESRENIF CSQASNLSTE MARDRHPITE GSAIPGDSMA
YGQPLQAGDE RGLDSRDVSA KLPESGSSSG LVATNSKGKK QKAKNSQGPG LSSTSSNVAN
LADSFNEQSQ SLNHPMADLL PQLLALQETM TQVMASQKEM QRQLSNAVTG PIVKEGKKLE
VALGRMIEKS SKSNADALWA HFQEEAVKNE KALRDHGQQI MNETTNFTSK ELNAMFEKTM
KKEFASVGPT LARVVTPVIE KTVSSAITES FQRGIGDKAV NQLEKSVNSK LETTVARQIQ
AQFQTSGRQV LQEGLRSSME SSVIPSFERS CKTMFEQVDS TLQKGIGKHT SATQQRIDSG
QSQLAHTLRE TISSASSVTQ ALNRELAESQ RNRLALTAAG SNPLVTQLSN GPLGALLEKV
EAPMDPTTEL SRLISERKYE ESFTSALQRS DVSIVSWLCS QVDLRGLLAM NPLPLSQGVL
LSLLQQLACD ISTDTSRKLG WMTDVVTAIN PSDQMIAVHA RPIFEQVYQI LHHHRNAPGS
DVSAVRLIMH VINSLLMSCK
