VCX1_HUMAN
ID VCX1_HUMAN Reviewed; 206 AA.
AC Q9H320; A0JNS5; Q4V774; Q9P0H3;
DT 16-NOV-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 127.
DE RecName: Full=Variable charge X-linked protein 1;
DE AltName: Full=Variable charge protein on X with ten repeats;
DE Short=VCX-10r;
DE AltName: Full=Variably charged protein X-B1;
DE Short=VCX-B1;
GN Name=VCX; Synonyms=VCX1, VCX10R, VCXB1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=10903929; DOI=10.1086/303047;
RA Fukami M., Kirsch S., Schiller S., Richter A., Benes V., Franco B.,
RA Muroya K., Rao E., Merker S., Niesler B., Ballabio A., Ansorge W.,
RA Ogata T., Rappold G.A.;
RT "A member of a gene family on Xp22.3, VCX-A, is deleted in patients with X-
RT linked nonspecific mental retardation.";
RL Am. J. Hum. Genet. 67:563-573(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA], AND VARIANT GLY-70.
RX PubMed=10607842; DOI=10.1093/hmg/9.2.311;
RA Lahn B.T., Page D.C.;
RT "A human sex-chromosomal gene family expressed in male germ cells and
RT encoding variably charged proteins.";
RL Hum. Mol. Genet. 9:311-319(2000).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS GLY-70 AND LEU-194.
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May mediate a process in spermatogenesis or may play a role
CC in sex ratio distortion.
CC -!- TISSUE SPECIFICITY: Expressed exclusively in testis.
CC -!- SIMILARITY: Belongs to the VCX/VCY family. {ECO:0000305}.
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DR EMBL; AF167081; AAG41767.1; -; mRNA.
DR EMBL; AF159129; AAF28174.1; -; mRNA.
DR EMBL; BC098123; AAH98123.1; -; mRNA.
DR EMBL; BC126903; AAI26904.1; -; mRNA.
DR CCDS; CCDS14128.1; -.
DR RefSeq; NP_038480.2; NM_013452.2.
DR AlphaFoldDB; Q9H320; -.
DR SMR; Q9H320; -.
DR BioGRID; 117763; 4.
DR STRING; 9606.ENSP00000370447; -.
DR iPTMnet; Q9H320; -.
DR PhosphoSitePlus; Q9H320; -.
DR BioMuta; VCX; -.
DR DMDM; 17368950; -.
DR MassIVE; Q9H320; -.
DR PaxDb; Q9H320; -.
DR PeptideAtlas; Q9H320; -.
DR PRIDE; Q9H320; -.
DR Antibodypedia; 52842; 57 antibodies from 12 providers.
DR DNASU; 26609; -.
DR Ensembl; ENST00000381059.7; ENSP00000370447.3; ENSG00000182583.13.
DR Ensembl; ENST00000688183.1; ENSP00000509688.1; ENSG00000182583.13.
DR GeneID; 26609; -.
DR KEGG; hsa:26609; -.
DR MANE-Select; ENST00000688183.1; ENSP00000509688.1; NM_001393662.1; NP_001380591.1.
DR UCSC; uc004crz.3; human.
DR CTD; 26609; -.
DR DisGeNET; 26609; -.
DR GeneCards; VCX; -.
DR HGNC; HGNC:12667; VCX.
DR HPA; ENSG00000182583; Tissue enriched (testis).
DR MIM; 300229; gene.
DR neXtProt; NX_Q9H320; -.
DR OpenTargets; ENSG00000182583; -.
DR PharmGKB; PA37290; -.
DR VEuPathDB; HostDB:ENSG00000182583; -.
DR eggNOG; KOG3216; Eukaryota.
DR GeneTree; ENSGT00440000034745; -.
DR InParanoid; Q9H320; -.
DR OMA; KYLTRAP; -.
DR PathwayCommons; Q9H320; -.
DR BioGRID-ORCS; 26609; 63 hits in 614 CRISPR screens.
DR GeneWiki; VCX; -.
DR GenomeRNAi; 26609; -.
DR Pharos; Q9H320; Tbio.
DR PRO; PR:Q9H320; -.
DR Proteomes; UP000005640; Chromosome X.
DR RNAct; Q9H320; protein.
DR Bgee; ENSG00000182583; Expressed in right testis and 71 other tissues.
DR ExpressionAtlas; Q9H320; baseline and differential.
DR Genevisible; Q9H320; HS.
DR GO; GO:0005730; C:nucleolus; IDA:UniProtKB.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0003682; F:chromatin binding; TAS:UniProtKB.
DR GO; GO:0007420; P:brain development; IBA:GO_Central.
DR GO; GO:0006325; P:chromatin organization; TAS:UniProtKB.
DR GO; GO:0042255; P:ribosome assembly; NAS:UniProtKB.
DR GO; GO:0007283; P:spermatogenesis; TAS:ProtInc.
DR InterPro; IPR026653; VCX/VCY1.
DR Pfam; PF15231; VCX_VCY; 1.
PE 2: Evidence at transcript level;
KW Reference proteome; Repeat.
FT CHAIN 1..206
FT /note="Variable charge X-linked protein 1"
FT /id="PRO_0000184659"
FT REPEAT 104..113
FT /note="1"
FT REPEAT 114..123
FT /note="2"
FT REPEAT 124..133
FT /note="3"
FT REPEAT 134..143
FT /note="4"
FT REPEAT 144..153
FT /note="5"
FT REPEAT 154..163
FT /note="6"
FT REPEAT 164..173
FT /note="7"
FT REPEAT 174..183
FT /note="8"
FT REPEAT 184..193
FT /note="9"
FT REPEAT 194..203
FT /note="10"
FT REGION 1..206
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 104..203
FT /note="10 X 10 AA tandem repeats of L-S-Q-E-S-[EQ]-V-E-E-P"
FT COMPBIAS 18..32
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 36..54
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 119..193
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 70
FT /note="A -> G (in dbSNP:rs6639946)"
FT /evidence="ECO:0000269|PubMed:10607842,
FT ECO:0000269|PubMed:15489334"
FT /id="VAR_070431"
FT VARIANT 194
FT /note="P -> L (in dbSNP:rs78342118)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_070432"
FT CONFLICT 15..17
FT /note="TEA -> KET (in Ref. 3; AAH98123)"
FT /evidence="ECO:0000305"
FT CONFLICT 108
FT /note="A -> S (in Ref. 3; AAH98123)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 206 AA; 22289 MW; 070880B5587C2BB0 CRC64;
MSPKPRASGP PAKATEAGKR KSSSQPSPSD PKKKTTKVAK KGKAVRRGRR GKKGAATKMA
AVTAPEAESA PAAPGPSDQP SQELPQHELP PEEPVSEGTQ HDPLSQEAEL EEPLSQESEV
EEPLSQESQV EEPLSQESEV EEPLSQESQV EEPLSQESEV EEPLSQESQV EEPLSQESEM
EEPLSQESQV EEPPSQESEM EELPSV
