VCX3_HUMAN
ID VCX3_HUMAN Reviewed; 186 AA.
AC Q9NNX9; Q9P0H4;
DT 16-NOV-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 123.
DE RecName: Full=Variable charge X-linked protein 3;
DE AltName: Full=Variable charge protein on X with eight repeats;
DE Short=VCX-8r;
DE AltName: Full=Variably charged protein X-A;
DE Short=VCX-A;
GN Name=VCX3A; Synonyms=VCX3, VCX8R, VCXA;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RX PubMed=10903929; DOI=10.1086/303047;
RA Fukami M., Kirsch S., Schiller S., Richter A., Benes V., Franco B.,
RA Muroya K., Rao E., Merker S., Niesler B., Ballabio A., Ansorge W.,
RA Ogata T., Rappold G.A.;
RT "A member of a gene family on Xp22.3, VCX-A, is deleted in patients with X-
RT linked nonspecific mental retardation.";
RL Am. J. Hum. Genet. 67:563-573(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=10607842; DOI=10.1093/hmg/9.2.311;
RA Lahn B.T., Page D.C.;
RT "A human sex-chromosomal gene family expressed in male germ cells and
RT encoding variably charged proteins.";
RL Hum. Mol. Genet. 9:311-319(2000).
CC -!- FUNCTION: May mediate a process in spermatogenesis or may play a role
CC in sex ratio distortion.
CC -!- TISSUE SPECIFICITY: Expressed exclusively in testis.
CC -!- SIMILARITY: Belongs to the VCX/VCY family. {ECO:0000305}.
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DR EMBL; AJ243947; CAB56197.1; -; Genomic_DNA.
DR EMBL; AF167078; AAG41764.1; -; mRNA.
DR EMBL; AF159128; AAF28173.1; -; mRNA.
DR CCDS; CCDS35199.1; -.
DR RefSeq; NP_057463.2; NM_016379.3.
DR AlphaFoldDB; Q9NNX9; -.
DR SMR; Q9NNX9; -.
DR STRING; 9606.ENSP00000370479; -.
DR iPTMnet; Q9NNX9; -.
DR PhosphoSitePlus; Q9NNX9; -.
DR BioMuta; VCX3A; -.
DR MassIVE; Q9NNX9; -.
DR PaxDb; Q9NNX9; -.
DR PeptideAtlas; Q9NNX9; -.
DR PRIDE; Q9NNX9; -.
DR Antibodypedia; 23556; 96 antibodies from 15 providers.
DR DNASU; 51481; -.
DR Ensembl; ENST00000381089.7; ENSP00000370479.3; ENSG00000169059.13.
DR GeneID; 51481; -.
DR KEGG; hsa:51481; -.
DR MANE-Select; ENST00000381089.7; ENSP00000370479.3; NM_016379.4; NP_057463.2.
DR UCSC; uc004crs.3; human.
DR CTD; 51481; -.
DR DisGeNET; 51481; -.
DR GeneCards; VCX3A; -.
DR HGNC; HGNC:18159; VCX3A.
DR HPA; ENSG00000169059; Tissue enriched (testis).
DR MIM; 300533; gene.
DR neXtProt; NX_Q9NNX9; -.
DR OpenTargets; ENSG00000169059; -.
DR PharmGKB; PA134936169; -.
DR VEuPathDB; HostDB:ENSG00000169059; -.
DR eggNOG; KOG3216; Eukaryota.
DR GeneTree; ENSGT00440000034745; -.
DR InParanoid; Q9NNX9; -.
DR PathwayCommons; Q9NNX9; -.
DR BioGRID-ORCS; 51481; 4 hits in 244 CRISPR screens.
DR GenomeRNAi; 51481; -.
DR Pharos; Q9NNX9; Tbio.
DR PRO; PR:Q9NNX9; -.
DR Proteomes; UP000005640; Chromosome X.
DR RNAct; Q9NNX9; protein.
DR Bgee; ENSG00000169059; Expressed in left testis and 61 other tissues.
DR ExpressionAtlas; Q9NNX9; baseline.
DR Genevisible; Q9NNX9; HS.
DR GO; GO:0005730; C:nucleolus; ISS:UniProtKB.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0007420; P:brain development; IMP:UniProtKB.
DR InterPro; IPR026653; VCX/VCY1.
DR Pfam; PF15231; VCX_VCY; 2.
PE 2: Evidence at transcript level;
KW Reference proteome; Repeat.
FT CHAIN 1..186
FT /note="Variable charge X-linked protein 3"
FT /id="PRO_0000184661"
FT REPEAT 104..113
FT /note="1"
FT REPEAT 114..123
FT /note="2"
FT REPEAT 124..133
FT /note="3"
FT REPEAT 134..143
FT /note="4"
FT REPEAT 144..153
FT /note="5"
FT REPEAT 154..163
FT /note="6"
FT REPEAT 164..173
FT /note="7"
FT REPEAT 174..183
FT /note="8"
FT REGION 1..186
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 104..183
FT /note="8 X 10 AA tandem repeats of L-S-Q-E-S-[EQ]-V-E-E-P"
FT COMPBIAS 18..32
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 36..54
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 119..173
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 108
FT /note="S -> A (in Ref. 2; AAF28173)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 186 AA; 20020 MW; 8C9C5F66FB97EE9A CRC64;
MSPKPRASGP PAKATEAGKR KSSSQPSPSD PKKKTTKVAK KGKAVRRGRR GKKGAATKMA
AVTAPEAESG PAAPGPSDQP SQELPQHELP PEEPVSEGTQ HDPLSQESEL EEPLSQESEV
EEPLSQESQV EEPLSQESEV EEPLSQESQV EEPLSQESEV EEPLSQESQV EEPLSQESEM
EELPSV
