VCY1_HUMAN
ID VCY1_HUMAN Reviewed; 125 AA.
AC O14598;
DT 15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 03-AUG-2022, entry version 138.
DE RecName: Full=Testis-specific basic protein Y 1;
DE AltName: Full=Basic charge, Y-linked 1;
DE AltName: Full=Variably charged protein Y;
GN Name=VCY; Synonyms=BPY1, VCY1A;
GN and
GN Name=VCY1B; Synonyms=BPY1B;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=9381176; DOI=10.1126/science.278.5338.675;
RA Lahn B.T., Page D.C.;
RT "Functional coherence of the human Y chromosome.";
RL Science 278:675-680(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12815422; DOI=10.1038/nature01722;
RA Skaletsky H., Kuroda-Kawaguchi T., Minx P.J., Cordum H.S., Hillier L.W.,
RA Brown L.G., Repping S., Pyntikova T., Ali J., Bieri T., Chinwalla A.,
RA Delehaunty A., Delehaunty K., Du H., Fewell G., Fulton L., Fulton R.,
RA Graves T.A., Hou S.-F., Latrielle P., Leonard S., Mardis E., Maupin R.,
RA McPherson J., Miner T., Nash W., Nguyen C., Ozersky P., Pepin K., Rock S.,
RA Rohlfing T., Scott K., Schultz B., Strong C., Tin-Wollam A., Yang S.-P.,
RA Waterston R.H., Wilson R.K., Rozen S., Page D.C.;
RT "The male-specific region of the human Y chromosome is a mosaic of discrete
RT sequence classes.";
RL Nature 423:825-837(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May mediate a process in spermatogenesis or may play a role
CC in sex ratio distortion.
CC -!- INTERACTION:
CC O14598; Q8IVP1: SH3GL3; NbExp=3; IntAct=EBI-8787564, EBI-6503765;
CC -!- TISSUE SPECIFICITY: Expressed exclusively in testis.
CC -!- SIMILARITY: Belongs to the VCX/VCY family. {ECO:0000305}.
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DR EMBL; AF000979; AAC51827.1; -; mRNA.
DR EMBL; AC006370; AAF03503.1; -; Genomic_DNA.
DR EMBL; BC056508; AAH56508.1; -; mRNA.
DR CCDS; CCDS56617.1; -.
DR CCDS; CCDS56618.1; -.
DR RefSeq; NP_004670.1; NM_004679.2.
DR RefSeq; NP_870996.1; NM_181880.1.
DR AlphaFoldDB; O14598; -.
DR BioGRID; 114540; 5.
DR BioGRID; 131701; 1.
DR IntAct; O14598; 3.
DR MINT; O14598; -.
DR iPTMnet; O14598; -.
DR PhosphoSitePlus; O14598; -.
DR BioMuta; VCY; -.
DR MassIVE; O14598; -.
DR PaxDb; O14598; -.
DR PeptideAtlas; O14598; -.
DR PRIDE; O14598; -.
DR ProteomicsDB; 48105; -.
DR Antibodypedia; 58314; 28 antibodies from 10 providers.
DR DNASU; 353513; -.
DR Ensembl; ENST00000250823.5; ENSP00000250823.4; ENSG00000129862.7.
DR Ensembl; ENST00000250825.5; ENSP00000250825.4; ENSG00000129864.7.
DR GeneID; 353513; -.
DR GeneID; 9084; -.
DR KEGG; hsa:353513; -.
DR KEGG; hsa:9084; -.
DR MANE-Select; ENST00000250823.5; ENSP00000250823.4; NM_181880.2; NP_870996.1.
DR MANE-Select; ENST00000250825.5; ENSP00000250825.4; NM_004679.4; NP_004670.1.
DR UCSC; uc004ftc.4; human.
DR CTD; 353513; -.
DR CTD; 9084; -.
DR DisGeNET; 9084; -.
DR GeneCards; VCY; -.
DR GeneCards; VCY1B; -.
DR GeneReviews; VCY; -.
DR HGNC; HGNC:12668; VCY.
DR HGNC; HGNC:31751; VCY1B.
DR HPA; ENSG00000129862; Tissue enriched (testis).
DR HPA; ENSG00000129864; Tissue enriched (testis).
DR MalaCards; VCY; -.
DR MIM; 400012; gene.
DR MIM; 400050; gene.
DR neXtProt; NX_O14598; -.
DR OpenTargets; ENSG00000129862; -.
DR PharmGKB; PA37291; -.
DR VEuPathDB; HostDB:ENSG00000129862; -.
DR VEuPathDB; HostDB:ENSG00000129864; -.
DR GeneTree; ENSGT00440000034745; -.
DR HOGENOM; CLU_108293_0_0_1; -.
DR InParanoid; O14598; -.
DR OMA; QESECVD; -.
DR PathwayCommons; O14598; -.
DR SignaLink; O14598; -.
DR BioGRID-ORCS; 353513; 2 hits in 580 CRISPR screens.
DR BioGRID-ORCS; 9084; 233 hits in 569 CRISPR screens.
DR Pharos; O14598; Tdark.
DR PRO; PR:O14598; -.
DR Proteomes; UP000005640; Chromosome Y.
DR RNAct; O14598; protein.
DR Bgee; ENSG00000129862; Expressed in left testis and 27 other tissues.
DR Genevisible; O14598; HS.
DR GO; GO:0007420; P:brain development; IBA:GO_Central.
DR InterPro; IPR026653; VCX/VCY1.
DR Pfam; PF15231; VCX_VCY; 1.
PE 1: Evidence at protein level;
KW Reference proteome.
FT CHAIN 1..125
FT /note="Testis-specific basic protein Y 1"
FT /id="PRO_0000184663"
FT REGION 1..125
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 34..50
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 125 AA; 12917 MW; D528561A52592E6C CRC64;
MSPKPRASGP PAKAKETGKR KSSSQPSPSG PKKKTTKVAE KGEAVRGGRR GKKGAATKMA
AVTAPEAESG PAAPGPSDQP SQELPQHELP PEEPVSEGTQ HDPLSQESEL EEPLSKGRPS
TPLSP
