ID   VCYCL_HHV8P             Reviewed;         257 AA.
AC   Q77Q36; D0UZU0;
DT   16-OCT-2013, integrated into UniProtKB/Swiss-Prot.
DT   15-MAY-2007, sequence version 1.
DT   29-SEP-2021, entry version 75.
DE   RecName: Full=viral cyclin homolog;
DE            Short=v-cyclin;
GN   Name=ORF72;
OS   Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's
OS   sarcoma-associated herpesvirus).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Gammaherpesvirinae; Rhadinovirus.
OX   NCBI_TaxID=868565;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=10400794; DOI=10.1128/jvi.73.8.6953-6963.1999;
RA   Glenn M., Rainbow L., Aurade F., Davison A., Schulz T.F.;
RT   "Identification of a spliced gene from Kaposi's sarcoma-associated
RT   herpesvirus encoding a protein with similarities to latent membrane
RT   proteins 1 and 2A of Epstein-Barr virus.";
RL   J. Virol. 73:6953-6963(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16760382; DOI=10.1099/vir.0.81919-0;
RA   Rezaee S.A.R., Cunningham C., Davison A.J., Blackbourn D.J.;
RT   "Kaposi's sarcoma-associated herpesvirus immune modulation: an overview.";
RL   J. Gen. Virol. 87:1781-1804(2006).
RN   [3]
RP   INTERACTION WITH HOST CDK6.
RX   PubMed=7935438; DOI=10.1128/mcb.14.11.7235-7244.1994;
RA   Jung J.U., Stager M., Desrosiers R.C.;
RT   "Virus-encoded cyclin.";
RL   Mol. Cell. Biol. 14:7235-7244(1994).
RN   [4]
RP   FUNCTION.
RX   PubMed=10519412;
RA   Ojala P.M., Tiainen M., Salven P., Veikkola T., Castanos-Velez E.,
RA   Sarid R., Biberfeld P., Makela T.P.;
RT   "Kaposi's sarcoma-associated herpesvirus-encoded v-cyclin triggers
RT   apoptosis in cells with high levels of cyclin-dependent kinase 6.";
RL   Cancer Res. 59:4984-4989(1999).
RN   [5]
RP   FUNCTION.
RX   PubMed=10091992; DOI=10.1099/0022-1317-80-3-549;
RA   Duro D., Schulze A., Vogt B., Bartek J., Mittnacht S., Jansen-Durr P.;
RT   "Activation of cyclin A gene expression by the cyclin encoded by human
RT   herpesvirus-8.";
RL   J. Gen. Virol. 80:549-555(1999).
RN   [6]
RP   FUNCTION.
RX   PubMed=11056537; DOI=10.1038/35041064;
RA   Ojala P.M., Yamamoto K., Castanos-Velez E., Biberfeld P., Korsmeyer S.J.,
RA   Makela T.P.;
RT   "The apoptotic v-cyclin-CDK6 complex phosphorylates and inactivates Bcl-
RT   2.";
RL   Nat. Cell Biol. 2:819-825(2000).
CC   -!- FUNCTION: Modulates host cell cycle progression and apoptotic signaling
CC       pathways by acting as a cyclin. Forms an active kinase complex with
CC       cellular CDK6 kinase. Promotes host S-phase entry of quiescent cells
CC       and activates host cyclin A. Triggers host apoptosis by inactivating
CC       host BCL2. {ECO:0000269|PubMed:10091992, ECO:0000269|PubMed:10519412,
CC       ECO:0000269|PubMed:11056537}.
CC   -!- SUBUNIT: Interacts with host CDK6. {ECO:0000269|PubMed:7935438}.
CC   -!- SIMILARITY: Belongs to the cyclin family. {ECO:0000305}.
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DR   EMBL; AF148805; AAD46500.1; -; Genomic_DNA.
DR   RefSeq; YP_001129430.1; NC_009333.1.
DR   SMR; Q77Q36; -.
DR   BioGRID; 1776974; 11.
DR   IntAct; Q77Q36; 4.
DR   PRIDE; Q77Q36; -.
DR   DNASU; 4961471; -.
DR   GeneID; 4961471; -.
DR   KEGG; vg:4961471; -.
DR   Proteomes; UP000000942; Genome.
DR   CDD; cd00043; CYCLIN; 1.
DR   InterPro; IPR039361; Cyclin.
DR   InterPro; IPR013763; Cyclin-like.
DR   InterPro; IPR036915; Cyclin-like_sf.
DR   InterPro; IPR015451; Cyclin_D.
DR   InterPro; IPR017285; Cyclin_herpesvir.
DR   InterPro; IPR006671; Cyclin_N.
DR   InterPro; IPR015164; K-cyclin_C.
DR   PANTHER; PTHR10177; PTHR10177; 1.
DR   PANTHER; PTHR10177:SF65; PTHR10177:SF65; 1.
DR   Pfam; PF00134; Cyclin_N; 1.
DR   Pfam; PF09080; K-cyclin_vir_C; 1.
DR   PIRSF; PIRSF037816; Viral_cyclin; 1.
DR   SMART; SM00385; CYCLIN; 1.
DR   SUPFAM; SSF47954; SSF47954; 2.
DR   PROSITE; PS00292; CYCLINS; 1.
PE   1: Evidence at protein level;
KW   Cyclin; Reference proteome.
FT   CHAIN           1..257
FT                   /note="viral cyclin homolog"
FT                   /id="PRO_0000423908"
SQ   SEQUENCE   257 AA;  28100 MW;  15EF6BAE9E790926 CRC64;
     MATANNPPSG LLDPTLCEDR IFYNILEIEP RFLTSDSVFG TFQQSLTSHM RKLLGTWMFS
     VCQEYNLEPN VVALALNLLD RLLLIKQVSK EHFQKTGSAC LLVASKLRSL TPISTSSLCY
     AAADSFSRQE LIDQEKELLE KLAWRTEAVL ATDVTSFLLL KLLGGSQHLD FWHHEVNTLI
     TKALVDPKTG SLPASIISAA GCALLVPANV IPQDTHSGGV VPQLASILGC DVSVLQAAVE
     QILTSVSDFD LRILDSY