ID   VD4L_CWPXG              Reviewed;         672 AA.
AC   O73579;
DT   13-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1998, sequence version 1.
DT   03-AUG-2022, entry version 75.
DE   RecName: Full=Ankyrin repeat protein D4L/I2R;
GN   ORFNames=D4L;
GN   and
GN   ORFNames=I2R;
OS   Cowpox virus (strain GRI-90 / Grishak) (CPV).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus.
OX   NCBI_TaxID=265871;
OH   NCBI_TaxID=9913; Bos taurus (Bovine).
OH   NCBI_TaxID=9685; Felis catus (Cat) (Felis silvestris catus).
OH   NCBI_TaxID=9606; Homo sapiens (Human).
OH   NCBI_TaxID=9785; Loxodonta africana (African elephant).
OH   NCBI_TaxID=29092; Microtus agrestis (Short-tailed field vole).
OH   NCBI_TaxID=10090; Mus musculus (Mouse).
OH   NCBI_TaxID=447135; Myodes glareolus (Bank vole) (Clethrionomys glareolus).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=9568042; DOI=10.1006/viro.1998.9039;
RA   Shchelkunov S.N., Safronov P.F., Totmenin A.V., Petrov N.A.,
RA   Ryazankina O.I., Gutorov V.V., Kotwal G.J.;
RT   "The genomic sequence analysis of the left and right species-specific
RT   terminal region of a cowpox virus strain reveals unique sequences and a
RT   cluster of intact ORFs for immunomodulatory and host range proteins.";
RL   Virology 243:432-460(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND SEQUENCE REVISION.
RX   PubMed=10732354;
RA   Riazankina O.I., Tumanova O.I.U., Kolosova I.V., Safronov P.F.,
RA   Kablova G.V., Riazankin I.A., Shchelkunov S.N.;
RT   "Structural-functional organization of Cowpox virus GRI-90 genome. I.
RT   Isolation of clones of DNA fragments of complete Cowpox virus genome.";
RL   Mol. Biol. (Mosk.) 34:160-166(2000).
CC   -!- CAUTION: This gene is present in the genome in two identical copies,
CC       one called D4L and the other one I2R. {ECO:0000305}.
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DR   EMBL; X94355; CAA64089.2; -; Genomic_DNA.
DR   EMBL; X94355; CAD90754.1; -; Genomic_DNA.
DR   SMR; O73579; -.
DR   PRIDE; O73579; -.
DR   Gene3D; 1.25.40.20; -; 2.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   InterPro; IPR018272; PRANC_domain.
DR   Pfam; PF09372; PRANC; 1.
DR   SMART; SM00248; ANK; 8.
DR   SUPFAM; SSF48403; SSF48403; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 2.
DR   PROSITE; PS50088; ANK_REPEAT; 1.
PE   4: Predicted;
KW   ANK repeat; Repeat.
FT   CHAIN           1..672
FT                   /note="Ankyrin repeat protein D4L/I2R"
FT                   /id="PRO_0000067101"
FT   REPEAT          41..74
FT                   /note="ANK 1"
FT   REPEAT          77..108
FT                   /note="ANK 2"
FT   REPEAT          196..231
FT                   /note="ANK 3"
FT   REPEAT          235..266
FT                   /note="ANK 4"
FT   REPEAT          282..312
FT                   /note="ANK 5"
FT   REPEAT          344..375
FT                   /note="ANK 6"
FT   REPEAT          378..410
FT                   /note="ANK 7"
FT   REPEAT          461..490
FT                   /note="ANK 8"
SQ   SEQUENCE   672 AA;  78659 MW;  45D8B939C873AF53 CRC64;
     MDYCGRECTI LRRLLDEDVT YKKIKLEIET CHNLSKHIDR RGNNALHCYV SNKCDTDIKI
     VRLLLSRGVE RLRRNNEGLT PLGAYSKHRH VKYQIVHLLI SSYSNSSNEL KSNINDFDLY
     SYMSSDNIDL RLLKYLIVDK RIRPSKNTNY AINGLGLVDI YVTTPNPRPE VLLWLLKSEC
     YSTGYVFRTC MYDSDMCKNS LHYYILSHRE SQSLSKDVIK CLIDNNVSIH GRDEGGSLPI
     QYYWSCSTID IEIVKLLIKD VDTCRVYDDI SQPYIRGVLA DYLNKRFRVT PYNVDMEIVN
     LLIEGRHTLI DVMRSITSYD SREYNHYIID NILKRFRQQD ESIVQAMLIN YLHYGDMVSI
     PIVRCMLDNG ATMDKTTDNN YPLHDYFVNN NLVDVNVVRF IVENNGHMAV NHVSNNGRLC
     MYGLILSRFN NCGYHCYETI LIDVFDILSK YMDDIDMIDN ENKTLLYYAV DVNNIQFAKR
     LLEYGANVNA TSLSIINTAI QKSSYRRENK TKLVDLLLSY HPTLETMIDA FNRDIRYLYP
     EPLLACIRYA LILDDDFPSK VKYDISGRHK ELKRYRADIN RMKNAYISGV SMFDILFKRS
     KRHRLRYAKN PTFINFVSNI KWYKKELTSI ITETVKNGER IDSIVDNINT DDNLISKLPM
     EIQREILYYS IK