VDAC1_ORYSJ
ID VDAC1_ORYSJ Reviewed; 274 AA.
AC Q6K548; A0A0P0XLN3; Q0J2B8; Q9LWA7;
DT 23-NOV-2004, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 3.
DT 25-MAY-2022, entry version 95.
DE RecName: Full=Mitochondrial outer membrane protein porin 1;
DE AltName: Full=Voltage-dependent anion-selective channel protein 1;
DE Short=OsVDAC1;
GN Name=VDAC1; OrderedLocusNames=Os09g0361400, LOC_Os09g19734;
GN ORFNames=P0711F01.56-1;
OS Oryza sativa subsp. japonica (Rice).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX NCBI_TaxID=39947;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], INDUCTION, DEVELOPMENTAL STAGE, AND TISSUE
RP SPECIFICITY.
RC TISSUE=Leaf, and Root;
RX PubMed=10675523; DOI=10.1016/s0005-2736(99)00246-1;
RA Roosens N., Al-Bitar F.A., Jacobs M., Homble F.;
RT "Characterization of a cDNA encoding a rice mitochondrial voltage-dependent
RT anion channel and its gene expression studied upon plant development and
RT osmotic stress.";
RL Biochim. Biophys. Acta 1463:470-476(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=16100779; DOI=10.1038/nature03895;
RG International rice genome sequencing project (IRGSP);
RT "The map-based sequence of the rice genome.";
RL Nature 436:793-800(2005).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=18089549; DOI=10.1093/nar/gkm978;
RG The rice annotation project (RAP);
RT "The rice annotation project database (RAP-DB): 2008 update.";
RL Nucleic Acids Res. 36:D1028-D1033(2008).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT "Improvement of the Oryza sativa Nipponbare reference genome using next
RT generation sequence and optical map data.";
RL Rice 6:4-4(2013).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=12869764; DOI=10.1126/science.1081288;
RG The rice full-length cDNA consortium;
RT "Collection, mapping, and annotation of over 28,000 cDNA clones from
RT japonica rice.";
RL Science 301:376-379(2003).
RN [6]
RP PROTEIN SEQUENCE OF 2-11, AND TISSUE SPECIFICITY.
RC STRAIN=cv. Nipponbare; TISSUE=Callus, Leaf, Panicle, Sheath, and Stem;
RX PubMed=14681440; DOI=10.1093/nar/gkh020;
RA Komatsu S., Kojima K., Suzuki K., Ozaki K., Higo K.;
RT "Rice proteome database based on two-dimensional polyacrylamide gel
RT electrophoresis: its status in 2003.";
RL Nucleic Acids Res. 32:D388-D392(2004).
RN [7]
RP TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, AND INDUCTION.
RX PubMed=12527425; DOI=10.1016/s0167-4781(02)00590-0;
RA Al Bitar F., Roosens N., Smeyers M., Vauterin M., Van Boxtel J., Jacobs M.,
RA Homble F.;
RT "Sequence analysis, transcriptional and posttranscriptional regulation of
RT the rice vdac family.";
RL Biochim. Biophys. Acta 1625:43-51(2003).
CC -!- FUNCTION: Forms a channel through the mitochondrial outer membrane that
CC allows diffusion of small hydrophilic molecules. The channel adopts an
CC open conformation at low or zero membrane potential and a closed
CC conformation at potentials above 30-40 mV. The open state has a weak
CC anion selectivity whereas the closed state is cation-selective (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed in shoots and roots. Also expressed in
CC callus, leaves, panicles, sheaths and stems.
CC {ECO:0000269|PubMed:10675523, ECO:0000269|PubMed:12527425,
CC ECO:0000269|PubMed:14681440}.
CC -!- DEVELOPMENTAL STAGE: Highly expressed during the first days following
CC germination and then decreases in the later growth stages.
CC {ECO:0000269|PubMed:10675523, ECO:0000269|PubMed:12527425}.
CC -!- INDUCTION: Not induced by osmotic stress. {ECO:0000269|PubMed:10675523,
CC ECO:0000269|PubMed:12527425}.
CC -!- DOMAIN: Consists mainly of membrane-spanning sided beta-sheets.
CC -!- SIMILARITY: Belongs to the eukaryotic mitochondrial porin (TC 1.B.8.1)
CC family. {ECO:0000305}.
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DR EMBL; Y18104; CAB82853.1; -; mRNA.
DR EMBL; AP005508; BAD23330.1; -; Genomic_DNA.
DR EMBL; AP008215; BAF24897.1; -; Genomic_DNA.
DR EMBL; AP014965; BAT07696.1; -; Genomic_DNA.
DR EMBL; AK060652; BAG87525.1; -; mRNA.
DR EMBL; AK061261; BAG87823.1; -; mRNA.
DR RefSeq; XP_015611862.1; XM_015756376.1.
DR AlphaFoldDB; Q6K548; -.
DR SMR; Q6K548; -.
DR STRING; 4530.OS09T0361400-01; -.
DR PaxDb; Q6K548; -.
DR PRIDE; Q6K548; -.
DR EnsemblPlants; Os09t0361400-01; Os09t0361400-01; Os09g0361400.
DR GeneID; 4346851; -.
DR Gramene; Os09t0361400-01; Os09t0361400-01; Os09g0361400.
DR KEGG; osa:4346851; -.
DR eggNOG; KOG3126; Eukaryota.
DR HOGENOM; CLU_069937_0_0_1; -.
DR InParanoid; Q6K548; -.
DR OMA; IYQRCND; -.
DR OrthoDB; 938262at2759; -.
DR PlantReactome; R-OSA-1119498; Phylloquinone biosynthesis.
DR Proteomes; UP000000763; Chromosome 9.
DR Proteomes; UP000059680; Chromosome 9.
DR ExpressionAtlas; Q6K548; baseline and differential.
DR Genevisible; Q6K548; OS.
DR GO; GO:0005741; C:mitochondrial outer membrane; IBA:GO_Central.
DR GO; GO:0046930; C:pore complex; IEA:UniProtKB-KW.
DR GO; GO:0015288; F:porin activity; IEA:UniProtKB-KW.
DR GO; GO:0008308; F:voltage-gated anion channel activity; IBA:GO_Central.
DR CDD; cd07306; Porin3_VDAC; 1.
DR Gene3D; 2.40.160.10; -; 1.
DR InterPro; IPR023614; Porin_dom_sf.
DR InterPro; IPR001925; Porin_Euk.
DR InterPro; IPR027246; Porin_Euk/Tom40.
DR PANTHER; PTHR11743; PTHR11743; 1.
DR Pfam; PF01459; Porin_3; 1.
DR PROSITE; PS00558; EUKARYOTIC_PORIN; 1.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Ion transport; Membrane; Mitochondrion;
KW Mitochondrion outer membrane; Porin; Reference proteome; Transmembrane;
KW Transmembrane beta strand; Transport.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000269|PubMed:14681440"
FT CHAIN 2..274
FT /note="Mitochondrial outer membrane protein porin 1"
FT /id="PRO_0000050529"
SQ SEQUENCE 274 AA; 29220 MW; 88852C154F3CC46F CRC64;
MVGPGLYPEI GKKARDLLYR DYQTDHKFTL TTYTSNGVAI TATSTKKADL IFGEIQSQIK
NKNITVDVKA NSDSNVVTTV TVDELTPGLK SILSFAVPDQ RSGKFELQYS HDYAGVSASI
GLTASPVVNL SSVFGTKALA VGADVSLDTA TGNLTKYNAG LSFSNDDLIA SLNLNNKGDS
LTASYYHIVN HSATAVGAEL THSFSSNENS LTFGTQHTLD PLTVVKARFN NSGKASALLQ
HEWRPKSVWT ISAEVDTKAI DKSSKVGIAV ALKP
