ID   VDAC1_WHEAT             Reviewed;         275 AA.
AC   P46274;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   03-AUG-2022, entry version 81.
DE   RecName: Full=Mitochondrial outer membrane porin;
DE   AltName: Full=Voltage-dependent anion-selective channel protein;
DE            Short=VDAC;
GN   Name=VDAC1;
OS   Triticum aestivum (Wheat).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC   Pooideae; Triticodae; Triticeae; Triticinae; Triticum.
OX   NCBI_TaxID=4565;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=cv. Atir; TISSUE=Root;
RX   PubMed=7579156; DOI=10.1007/bf00019123;
RA   Elkeles A., Devos K.M., Graur D., Zizi M., Breiman A.;
RT   "Multiple cDNAs of wheat voltage-dependent anion channels (VDAC):
RT   isolation, differential expression, mapping and evolution.";
RL   Plant Mol. Biol. 29:109-124(1995).
CC   -!- FUNCTION: Forms a channel through the cell membrane that allows
CC       diffusion of small hydrophilic molecules. The channel adopts an open
CC       conformation at low or zero membrane potential and a closed
CC       conformation at potentials above 30-40 mV. The open state has a weak
CC       anion selectivity whereas the closed state is cation-selective (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion outer membrane.
CC   -!- DOMAIN: Consists mainly of membrane-spanning sided beta-sheets.
CC   -!- SIMILARITY: Belongs to the eukaryotic mitochondrial porin (TC 1.B.8.1)
CC       family. {ECO:0000305}.
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DR   EMBL; X77733; CAA54788.1; -; mRNA.
DR   PIR; S59545; S59545.
DR   AlphaFoldDB; P46274; -.
DR   SMR; P46274; -.
DR   STRING; 4565.Traes_5DL_469B4E877.1; -.
DR   TCDB; 1.B.8.1.4; the mitochondrial and plastid porin (mpp) family.
DR   PRIDE; P46274; -.
DR   eggNOG; KOG1223; Eukaryota.
DR   eggNOG; KOG3126; Eukaryota.
DR   Proteomes; UP000019116; Unplaced.
DR   ExpressionAtlas; P46274; baseline and differential.
DR   GO; GO:0005741; C:mitochondrial outer membrane; IBA:GO_Central.
DR   GO; GO:0046930; C:pore complex; IEA:UniProtKB-KW.
DR   GO; GO:0015288; F:porin activity; IEA:UniProtKB-KW.
DR   GO; GO:0008308; F:voltage-gated anion channel activity; IBA:GO_Central.
DR   CDD; cd07306; Porin3_VDAC; 1.
DR   Gene3D; 2.40.160.10; -; 1.
DR   InterPro; IPR023614; Porin_dom_sf.
DR   InterPro; IPR001925; Porin_Euk.
DR   InterPro; IPR027246; Porin_Euk/Tom40.
DR   PANTHER; PTHR11743; PTHR11743; 1.
DR   Pfam; PF01459; Porin_3; 1.
DR   PROSITE; PS00558; EUKARYOTIC_PORIN; 1.
PE   2: Evidence at transcript level;
KW   Ion transport; Membrane; Mitochondrion; Mitochondrion outer membrane;
KW   Porin; Reference proteome; Transmembrane; Transmembrane beta strand;
KW   Transport.
FT   CHAIN           1..275
FT                   /note="Mitochondrial outer membrane porin"
FT                   /id="PRO_0000050533"
SQ   SEQUENCE   275 AA;  28905 MW;  BCF788D7A0F3B33A CRC64;
     MGGPGLYSGI GKKAKDLLYR DYQTDHKFTL TTYTANGPAI TATSTKKADL TVGEIQSQIK
     NKNITVDVKA NSASNVITTI TADDLAAPGL KTILSFAVPD QKSGKVELQY LHDYAGINAS
     IGLTANPVVN LSGAFGTSAL AVGADVSLDT ATKNFAKYNA ALSYTNQDLI ASLNLNNKGD
     SLTASYYHIV EKSGTAVGAE LTHSFSSNEN SLTFGTQHTL DPLTLVKARI NNSGKASALI
     QHEFMPKSLC TISAEVDTKA IEKSSKVGIA IALKP