VDAC2_ORYSJ
ID VDAC2_ORYSJ Reviewed; 280 AA.
AC Q6L5I5; A0A0P0WQB1; Q8VXC7;
DT 14-DEC-2011, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 98.
DE RecName: Full=Mitochondrial outer membrane protein porin 2;
DE AltName: Full=Voltage-dependent anion-selective channel protein 2;
DE Short=OsVDAC2;
GN Name=VDAC2; OrderedLocusNames=Os05g0536200, LOC_Os05g45950;
GN ORFNames=OJ1741_B01.9, OsJ_19349;
OS Oryza sativa subsp. japonica (Rice).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX NCBI_TaxID=39947;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, AND
RP INDUCTION.
RC STRAIN=cv. Nipponbare;
RX PubMed=12527425; DOI=10.1016/s0167-4781(02)00590-0;
RA Al Bitar F., Roosens N., Smeyers M., Vauterin M., Van Boxtel J., Jacobs M.,
RA Homble F.;
RT "Sequence analysis, transcriptional and posttranscriptional regulation of
RT the rice vdac family.";
RL Biochim. Biophys. Acta 1625:43-51(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=16261349; DOI=10.1007/s00438-005-0039-y;
RA Cheng C.-H., Chung M.C., Liu S.-M., Chen S.-K., Kao F.Y., Lin S.-J.,
RA Hsiao S.-H., Tseng I.C., Hsing Y.-I.C., Wu H.-P., Chen C.-S., Shaw J.-F.,
RA Wu J., Matsumoto T., Sasaki T., Chen H.-C., Chow T.-Y.;
RT "A fine physical map of the rice chromosome 5.";
RL Mol. Genet. Genomics 274:337-345(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=16100779; DOI=10.1038/nature03895;
RG International rice genome sequencing project (IRGSP);
RT "The map-based sequence of the rice genome.";
RL Nature 436:793-800(2005).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=18089549; DOI=10.1093/nar/gkm978;
RG The rice annotation project (RAP);
RT "The rice annotation project database (RAP-DB): 2008 update.";
RL Nucleic Acids Res. 36:D1028-D1033(2008).
RN [5]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT "Improvement of the Oryza sativa Nipponbare reference genome using next
RT generation sequence and optical map data.";
RL Rice 6:4-4(2013).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=15685292; DOI=10.1371/journal.pbio.0030038;
RA Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S.,
RA Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L.,
RA Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J.,
RA Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X.,
RA Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y.,
RA Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L.,
RA Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H.,
RA Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z.,
RA Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L.,
RA Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F.,
RA Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q.,
RA Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J.,
RA Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M.,
RA McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H.;
RT "The genomes of Oryza sativa: a history of duplications.";
RL PLoS Biol. 3:266-281(2005).
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=12869764; DOI=10.1126/science.1081288;
RG The rice full-length cDNA consortium;
RT "Collection, mapping, and annotation of over 28,000 cDNA clones from
RT japonica rice.";
RL Science 301:376-379(2003).
RN [8]
RP TISSUE SPECIFICITY.
RX PubMed=12427548; DOI=10.1016/s0167-4781(02)00532-8;
RA Al Bitar F., Roosens N., Boxtel J.V., Dewaele E., Jacobs M., Homble F.;
RT "Expression of the rice vdac isoform2: histochemical localization and
RT expression level.";
RL Biochim. Biophys. Acta 1579:133-141(2002).
CC -!- FUNCTION: Forms a channel through the mitochondrial outer membrane that
CC allows diffusion of small hydrophilic molecules. The channel adopts an
CC open conformation at low or zero membrane potential and a closed
CC conformation at potentials above 30-40 mV. The open state has a weak
CC anion selectivity whereas the closed state is cation-selective (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed in roots, stems, leaves, palea, lemma and
CC pollen. {ECO:0000269|PubMed:12427548, ECO:0000269|PubMed:12527425}.
CC -!- DEVELOPMENTAL STAGE: Highly expressed during the first days following
CC germination and then decreases with time.
CC {ECO:0000269|PubMed:12527425}.
CC -!- INDUCTION: Not induced by osmotic stress.
CC {ECO:0000269|PubMed:12527425}.
CC -!- DOMAIN: Consists mainly of membrane-spanning sided beta-sheets.
CC -!- SIMILARITY: Belongs to the eukaryotic mitochondrial porin (TC 1.B.8.1)
CC family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AJ251562; CAC80850.1; -; mRNA.
DR EMBL; AC097112; AAT39214.1; -; Genomic_DNA.
DR EMBL; AP008211; BAF18076.1; -; Genomic_DNA.
DR EMBL; AP014961; BAS95080.1; -; Genomic_DNA.
DR EMBL; CM000142; EEE64499.1; -; Genomic_DNA.
DR EMBL; AK071833; BAG92718.1; -; mRNA.
DR RefSeq; XP_015639259.1; XM_015783773.1.
DR AlphaFoldDB; Q6L5I5; -.
DR SMR; Q6L5I5; -.
DR STRING; 4530.OS05T0536200-01; -.
DR PaxDb; Q6L5I5; -.
DR PRIDE; Q6L5I5; -.
DR EnsemblPlants; Os05t0536200-01; Os05t0536200-01; Os05g0536200.
DR GeneID; 4339446; -.
DR Gramene; Os05t0536200-01; Os05t0536200-01; Os05g0536200.
DR KEGG; osa:4339446; -.
DR eggNOG; KOG3126; Eukaryota.
DR HOGENOM; CLU_069937_0_0_1; -.
DR InParanoid; Q6L5I5; -.
DR OMA; ITLTEKW; -.
DR OrthoDB; 938262at2759; -.
DR Proteomes; UP000000763; Chromosome 5.
DR Proteomes; UP000007752; Chromosome 5.
DR Proteomes; UP000059680; Chromosome 5.
DR Genevisible; Q6L5I5; OS.
DR GO; GO:0005741; C:mitochondrial outer membrane; IBA:GO_Central.
DR GO; GO:0046930; C:pore complex; IEA:UniProtKB-KW.
DR GO; GO:0015288; F:porin activity; IEA:UniProtKB-KW.
DR GO; GO:0008308; F:voltage-gated anion channel activity; IBA:GO_Central.
DR CDD; cd07306; Porin3_VDAC; 1.
DR Gene3D; 2.40.160.10; -; 1.
DR InterPro; IPR023614; Porin_dom_sf.
DR InterPro; IPR001925; Porin_Euk.
DR InterPro; IPR027246; Porin_Euk/Tom40.
DR PANTHER; PTHR11743; PTHR11743; 1.
DR Pfam; PF01459; Porin_3; 1.
PE 2: Evidence at transcript level;
KW Ion transport; Membrane; Mitochondrion; Mitochondrion outer membrane;
KW Porin; Reference proteome; Transmembrane; Transmembrane beta strand;
KW Transport.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250"
FT CHAIN 2..280
FT /note="Mitochondrial outer membrane protein porin 2"
FT /id="PRO_0000414085"
SQ SEQUENCE 280 AA; 29602 MW; 2000466DFAE29429 CRC64;
MAAAAPPAGP GLYSDIGKKA RDLLYRDYHT DQKFTLTTYA ANGAAITVAG TKKNESIFSE
IQSQVKNNNV SVDVKATSDS KLITTFTVHD LGTPGLKGIL SIPFPYQKSA KAEVQYLHPH
AGLNAIVGLN ANPLVSFSGV FGTGAFAVGT DVAFDTATGD FTKYNAGLSH TTPDLTAALL
LNNKGDSLAA SYYHKVSKTS AVGAELAHSF SSNENTLTFG TQHALDELTT VKARFNNFGM
ASALIQHEFR PKSLVTISTE VDTKAIDKSS KVGLSLVLKP
