ID   VDAC2_SOLTU             Reviewed;         276 AA.
AC   P42056;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 2.
DT   25-MAY-2022, entry version 93.
DE   RecName: Full=Mitochondrial outer membrane protein porin of 36 kDa;
DE   AltName: Full=POM 36;
DE   AltName: Full=Voltage-dependent anion-selective channel protein;
DE            Short=VDAC;
OS   Solanum tuberosum (Potato).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   asterids; lamiids; Solanales; Solanaceae; Solanoideae; Solaneae; Solanum.
OX   NCBI_TaxID=4113;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND PROTEIN SEQUENCE OF 2-23.
RC   STRAIN=cv. Bintje; TISSUE=Tuber;
RX   PubMed=7929361; DOI=10.1016/s0021-9258(18)47208-0;
RA   Heins L., Mentzel H., Schmid A., Benz R., Schmitz U.K.;
RT   "Biochemical, molecular, and functional characterization of porin isoforms
RT   from potato mitochondria.";
RL   J. Biol. Chem. 269:26402-26410(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. DM1-3 516 R44;
RX   PubMed=21743474; DOI=10.1038/nature10158;
RG   The Potato Genome Sequencing Consortium;
RT   "Genome sequence and analysis of the tuber crop potato.";
RL   Nature 475:189-195(2011).
CC   -!- FUNCTION: Forms a channel through the cell membrane that allows
CC       diffusion of small hydrophilic molecules. The channel adopts an open
CC       conformation at low or zero membrane potential and a closed
CC       conformation at potentials above 30-40 mV. The open state has a weak
CC       anion selectivity whereas the closed state is cation-selective (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion outer membrane.
CC   -!- DOMAIN: Consists mainly of membrane-spanning sided beta-sheets.
CC   -!- SIMILARITY: Belongs to the eukaryotic mitochondrial porin (TC 1.B.8.1)
CC       family. {ECO:0000305}.
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DR   EMBL; X80387; CAA56600.1; -; mRNA.
DR   EMBL; X80388; CAA56601.1; -; mRNA.
DR   PIR; C55364; C55364.
DR   PIR; S46959; S46959.
DR   RefSeq; NP_001275134.1; NM_001288205.1.
DR   AlphaFoldDB; P42056; -.
DR   SMR; P42056; -.
DR   IntAct; P42056; 1.
DR   STRING; 4113.PGSC0003DMT400002261; -.
DR   CarbonylDB; P42056; -.
DR   PRIDE; P42056; -.
DR   EnsemblPlants; PGSC0003DMT400002261; PGSC0003DMT400002261; PGSC0003DMG400000864.
DR   GeneID; 102603136; -.
DR   Gramene; PGSC0003DMT400002261; PGSC0003DMT400002261; PGSC0003DMG400000864.
DR   KEGG; sot:102603136; -.
DR   eggNOG; KOG3126; Eukaryota.
DR   HOGENOM; CLU_069937_0_0_1; -.
DR   InParanoid; P42056; -.
DR   OMA; IYQRCND; -.
DR   OrthoDB; 938262at2759; -.
DR   Proteomes; UP000011115; Unassembled WGS sequence.
DR   GO; GO:0005741; C:mitochondrial outer membrane; IBA:GO_Central.
DR   GO; GO:0046930; C:pore complex; IEA:UniProtKB-KW.
DR   GO; GO:0015288; F:porin activity; IEA:UniProtKB-KW.
DR   GO; GO:0008308; F:voltage-gated anion channel activity; IBA:GO_Central.
DR   CDD; cd07306; Porin3_VDAC; 1.
DR   Gene3D; 2.40.160.10; -; 1.
DR   InterPro; IPR023614; Porin_dom_sf.
DR   InterPro; IPR001925; Porin_Euk.
DR   InterPro; IPR027246; Porin_Euk/Tom40.
DR   PANTHER; PTHR11743; PTHR11743; 1.
DR   Pfam; PF01459; Porin_3; 1.
DR   PROSITE; PS00558; EUKARYOTIC_PORIN; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Ion transport; Membrane; Mitochondrion;
KW   Mitochondrion outer membrane; Porin; Reference proteome; Transmembrane;
KW   Transmembrane beta strand; Transport.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000269|PubMed:7929361"
FT   CHAIN           2..276
FT                   /note="Mitochondrial outer membrane protein porin of 36
FT                   kDa"
FT                   /id="PRO_0000050532"
FT   VARIANT         73
FT                   /note="T -> A"
SQ   SEQUENCE   276 AA;  29394 MW;  A26E852526E77AAC CRC64;
     MVKGPGLYSD IGKKARDLLY RDYVSDHKFT VTTYSTTGVA ITASGLKKGE LFLADVSTQL
     KNKNITTDVK VDTNSNVYTT ITVDEPAPGL KTIFSFVVPD QKSGKVELQY LHEYAGINTS
     IGLTASPLVN FSGVAGNNTV ALGTDLSFDT ATGNFTKCNA GLSFSSSDLI ASLALNDKGD
     TVSASYYHTV KPVTNTAVGA ELTHSFSSNE NTLTIGTQHL LDPLTTVKAR VNSYGKASAL
     IQHEWRPKSL FTISGEVDTR AIEKSAKIGL AVALKP