ID   VDAC2_YEAST             Reviewed;         281 AA.
AC   P40478; D6VVH3;
DT   01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1995, sequence version 1.
DT   03-AUG-2022, entry version 159.
DE   RecName: Full=Mitochondrial outer membrane protein porin 2;
DE   AltName: Full=Voltage-dependent anion-selective channel protein 2;
DE            Short=VDAC-2;
GN   Name=POR2; OrderedLocusNames=YIL114C;
OS   Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=559292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=9169870;
RA   Churcher C.M., Bowman S., Badcock K., Bankier A.T., Brown D.,
RA   Chillingworth T., Connor R., Devlin K., Gentles S., Hamlin N., Harris D.E.,
RA   Horsnell T., Hunt S., Jagels K., Jones M., Lye G., Moule S., Odell C.,
RA   Pearson D., Rajandream M.A., Rice P., Rowley N., Skelton J., Smith V.,
RA   Walsh S.V., Whitehead S., Barrell B.G.;
RT   "The nucleotide sequence of Saccharomyces cerevisiae chromosome IX.";
RL   Nature 387:84-87(1997).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=24374639; DOI=10.1534/g3.113.008995;
RA   Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA   Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA   Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT   "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL   G3 (Bethesda) 4:389-398(2014).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=17322287; DOI=10.1101/gr.6037607;
RA   Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F.,
RA   Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J.,
RA   Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J.,
RA   Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D.,
RA   LaBaer J.;
RT   "Approaching a complete repository of sequence-verified protein-encoding
RT   clones for Saccharomyces cerevisiae.";
RL   Genome Res. 17:536-543(2007).
RN   [4]
RP   CHARACTERIZATION.
RX   PubMed=9315631; DOI=10.1128/mcb.17.10.5727;
RA   Blachly-Dyson E., Song J., Colombini M., Forte M.A.;
RT   "Multicopy suppressors of phenotypes resulting from the absence of yeast
RT   VDAC encode a VDAC-like protein.";
RL   Mol. Cell. Biol. 17:5727-5738(1997).
CC   -!- FUNCTION: Forms a channel through the cell membrane that allows
CC       diffusion of small hydrophilic molecules. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the eukaryotic mitochondrial porin family.
CC       {ECO:0000305}.
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DR   EMBL; Z38125; CAA86266.1; -; Genomic_DNA.
DR   EMBL; AY692875; AAT92894.1; -; Genomic_DNA.
DR   EMBL; BK006942; DAA08439.1; -; Genomic_DNA.
DR   PIR; S48458; S48458.
DR   RefSeq; NP_012152.3; NM_001179462.3.
DR   AlphaFoldDB; P40478; -.
DR   SMR; P40478; -.
DR   BioGRID; 34877; 30.
DR   DIP; DIP-7189N; -.
DR   IntAct; P40478; 4.
DR   MINT; P40478; -.
DR   STRING; 4932.YIL114C; -.
DR   TCDB; 1.B.8.1.18; the mitochondrial and plastid porin (mpp) family.
DR   iPTMnet; P40478; -.
DR   MaxQB; P40478; -.
DR   PaxDb; P40478; -.
DR   PRIDE; P40478; -.
DR   DNASU; 854692; -.
DR   EnsemblFungi; YIL114C_mRNA; YIL114C; YIL114C.
DR   GeneID; 854692; -.
DR   KEGG; sce:YIL114C; -.
DR   SGD; S000001376; POR2.
DR   VEuPathDB; FungiDB:YIL114C; -.
DR   eggNOG; KOG3126; Eukaryota.
DR   GeneTree; ENSGT00950000182869; -.
DR   HOGENOM; CLU_044399_0_1_1; -.
DR   InParanoid; P40478; -.
DR   OMA; ITLTEKW; -.
DR   BioCyc; YEAST:G3O-31368-MON; -.
DR   Reactome; R-SCE-70268; Pyruvate metabolism.
DR   PRO; PR:P40478; -.
DR   Proteomes; UP000002311; Chromosome IX.
DR   RNAct; P40478; protein.
DR   GO; GO:0005741; C:mitochondrial outer membrane; IDA:SGD.
DR   GO; GO:0005739; C:mitochondrion; HDA:SGD.
DR   GO; GO:0046930; C:pore complex; IEA:UniProtKB-KW.
DR   GO; GO:0015288; F:porin activity; IEA:UniProtKB-KW.
DR   GO; GO:0008308; F:voltage-gated anion channel activity; ISS:SGD.
DR   GO; GO:0045454; P:cell redox homeostasis; IMP:SGD.
DR   GO; GO:0051027; P:DNA transport; IMP:SGD.
DR   GO; GO:0006811; P:ion transport; ISS:SGD.
DR   GO; GO:0071902; P:positive regulation of protein serine/threonine kinase activity; IGI:SGD.
DR   CDD; cd07306; Porin3_VDAC; 1.
DR   Gene3D; 2.40.160.10; -; 1.
DR   InterPro; IPR023614; Porin_dom_sf.
DR   InterPro; IPR001925; Porin_Euk.
DR   InterPro; IPR027246; Porin_Euk/Tom40.
DR   PANTHER; PTHR11743; PTHR11743; 1.
DR   Pfam; PF01459; Porin_3; 1.
DR   PRINTS; PR00185; EUKARYTPORIN.
DR   PROSITE; PS00558; EUKARYOTIC_PORIN; 1.
PE   1: Evidence at protein level;
KW   Ion transport; Membrane; Mitochondrion; Mitochondrion outer membrane;
KW   Porin; Reference proteome; Transmembrane; Transmembrane beta strand;
KW   Transport.
FT   CHAIN           1..281
FT                   /note="Mitochondrial outer membrane protein porin 2"
FT                   /id="PRO_0000050525"
SQ   SEQUENCE   281 AA;  31177 MW;  C4BCAEED478F22A4 CRC64;
     MALRFFNDIS RDVNGLFNRD FFHTNPLSLN ISTTTENGVN FTLKAKQGVT EGPIQTSVEG
     RFYDRKEGVS LSQSWSNQNR LNTRIEFSKI APGWKGDVNA FLTPQSIKNA KFNLSYAQKS
     FAARTSIDIL QPKDFVGSVT LGHRGFVGGT DIAYDTAAGL CARYAMSIGY LAREYSFILS
     TNNRQCATAS FFQNVNRYLQ VGTKATLQSK TSSNMNIEFV TRYVPDSISQ VKAKIADSGL
     TTLSYKRNLN KDISLGVGMS FNALQLTEPV HKFGWSLSFS P