ID   VDAC3_ORYSJ             Reviewed;         275 AA.
AC   Q7F4F8; A0A0P0V4M3; Q8VXC6;
DT   14-DEC-2011, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 103.
DE   RecName: Full=Mitochondrial outer membrane protein porin 3;
DE   AltName: Full=Voltage-dependent anion-selective channel protein 3;
DE            Short=OsVDAC3;
GN   Name=VDAC3; OrderedLocusNames=Os01g0588200, LOC_Os01g40570;
GN   ORFNames=OsJ_02405, P0700A11.20;
OS   Oryza sativa subsp. japonica (Rice).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC   Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX   NCBI_TaxID=39947;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, AND
RP   INDUCTION.
RC   STRAIN=cv. Nipponbare; TISSUE=Panicle;
RX   PubMed=12527425; DOI=10.1016/s0167-4781(02)00590-0;
RA   Al Bitar F., Roosens N., Smeyers M., Vauterin M., Van Boxtel J., Jacobs M.,
RA   Homble F.;
RT   "Sequence analysis, transcriptional and posttranscriptional regulation of
RT   the rice vdac family.";
RL   Biochim. Biophys. Acta 1625:43-51(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=12447438; DOI=10.1038/nature01184;
RA   Sasaki T., Matsumoto T., Yamamoto K., Sakata K., Baba T., Katayose Y.,
RA   Wu J., Niimura Y., Cheng Z., Nagamura Y., Antonio B.A., Kanamori H.,
RA   Hosokawa S., Masukawa M., Arikawa K., Chiden Y., Hayashi M., Okamoto M.,
RA   Ando T., Aoki H., Arita K., Hamada M., Harada C., Hijishita S., Honda M.,
RA   Ichikawa Y., Idonuma A., Iijima M., Ikeda M., Ikeno M., Ito S., Ito T.,
RA   Ito Y., Ito Y., Iwabuchi A., Kamiya K., Karasawa W., Katagiri S.,
RA   Kikuta A., Kobayashi N., Kono I., Machita K., Maehara T., Mizuno H.,
RA   Mizubayashi T., Mukai Y., Nagasaki H., Nakashima M., Nakama Y.,
RA   Nakamichi Y., Nakamura M., Namiki N., Negishi M., Ohta I., Ono N., Saji S.,
RA   Sakai K., Shibata M., Shimokawa T., Shomura A., Song J., Takazaki Y.,
RA   Terasawa K., Tsuji K., Waki K., Yamagata H., Yamane H., Yoshiki S.,
RA   Yoshihara R., Yukawa K., Zhong H., Iwama H., Endo T., Ito H., Hahn J.H.,
RA   Kim H.-I., Eun M.-Y., Yano M., Jiang J., Gojobori T.;
RT   "The genome sequence and structure of rice chromosome 1.";
RL   Nature 420:312-316(2002).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=16100779; DOI=10.1038/nature03895;
RG   International rice genome sequencing project (IRGSP);
RT   "The map-based sequence of the rice genome.";
RL   Nature 436:793-800(2005).
RN   [4]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=18089549; DOI=10.1093/nar/gkm978;
RG   The rice annotation project (RAP);
RT   "The rice annotation project database (RAP-DB): 2008 update.";
RL   Nucleic Acids Res. 36:D1028-D1033(2008).
RN   [5]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA   Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA   Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA   Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA   Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT   "Improvement of the Oryza sativa Nipponbare reference genome using next
RT   generation sequence and optical map data.";
RL   Rice 6:4-4(2013).
RN   [6]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=15685292; DOI=10.1371/journal.pbio.0030038;
RA   Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S.,
RA   Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L.,
RA   Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J.,
RA   Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X.,
RA   Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y.,
RA   Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L.,
RA   Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H.,
RA   Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z.,
RA   Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L.,
RA   Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F.,
RA   Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q.,
RA   Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J.,
RA   Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M.,
RA   McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H.;
RT   "The genomes of Oryza sativa: a history of duplications.";
RL   PLoS Biol. 3:266-281(2005).
RN   [7]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=12869764; DOI=10.1126/science.1081288;
RG   The rice full-length cDNA consortium;
RT   "Collection, mapping, and annotation of over 28,000 cDNA clones from
RT   japonica rice.";
RL   Science 301:376-379(2003).
CC   -!- FUNCTION: Forms a channel through the mitochondrial outer membrane that
CC       allows diffusion of small hydrophilic molecules. The channel adopts an
CC       open conformation at low or zero membrane potential and a closed
CC       conformation at potentials above 30-40 mV. The open state has a weak
CC       anion selectivity whereas the closed state is cation-selective (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Highly expressed in flowers and at lower levels in
CC       roots and leaves. {ECO:0000269|PubMed:12527425}.
CC   -!- DEVELOPMENTAL STAGE: Highly expressed during the first days following
CC       germination and then decreases with time.
CC       {ECO:0000269|PubMed:12527425}.
CC   -!- INDUCTION: Not induced by osmotic stress.
CC       {ECO:0000269|PubMed:12527425}.
CC   -!- DOMAIN: Consists mainly of membrane-spanning sided beta-sheets.
CC   -!- SIMILARITY: Belongs to the eukaryotic mitochondrial porin (TC 1.B.8.1)
CC       family. {ECO:0000305}.
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DR   EMBL; AJ251563; CAC80851.1; -; mRNA.
DR   EMBL; AP003300; BAB89921.1; -; Genomic_DNA.
DR   EMBL; AP008207; BAF05347.1; -; Genomic_DNA.
DR   EMBL; AP014957; BAS72920.1; -; Genomic_DNA.
DR   EMBL; CM000138; EAZ12509.1; -; Genomic_DNA.
DR   EMBL; AK070745; BAG92122.1; -; mRNA.
DR   EMBL; AK104419; BAG96666.1; -; mRNA.
DR   RefSeq; XP_015611950.1; XM_015756464.1.
DR   AlphaFoldDB; Q7F4F8; -.
DR   SMR; Q7F4F8; -.
DR   STRING; 4530.OS01T0588200-01; -.
DR   PaxDb; Q7F4F8; -.
DR   PRIDE; Q7F4F8; -.
DR   EnsemblPlants; Os01t0588200-01; Os01t0588200-01; Os01g0588200.
DR   EnsemblPlants; Os01t0588200-02; Os01t0588200-02; Os01g0588200.
DR   GeneID; 4327665; -.
DR   Gramene; Os01t0588200-01; Os01t0588200-01; Os01g0588200.
DR   Gramene; Os01t0588200-02; Os01t0588200-02; Os01g0588200.
DR   KEGG; osa:4327665; -.
DR   eggNOG; KOG3126; Eukaryota.
DR   HOGENOM; CLU_069937_0_0_1; -.
DR   InParanoid; Q7F4F8; -.
DR   OMA; IKTAYKC; -.
DR   OrthoDB; 938262at2759; -.
DR   Proteomes; UP000000763; Chromosome 1.
DR   Proteomes; UP000007752; Chromosome 1.
DR   Proteomes; UP000059680; Chromosome 1.
DR   Genevisible; Q7F4F8; OS.
DR   GO; GO:0005741; C:mitochondrial outer membrane; IBA:GO_Central.
DR   GO; GO:0046930; C:pore complex; IEA:UniProtKB-KW.
DR   GO; GO:0015288; F:porin activity; IEA:UniProtKB-KW.
DR   GO; GO:0008308; F:voltage-gated anion channel activity; IBA:GO_Central.
DR   CDD; cd07306; Porin3_VDAC; 1.
DR   Gene3D; 2.40.160.10; -; 1.
DR   InterPro; IPR023614; Porin_dom_sf.
DR   InterPro; IPR001925; Porin_Euk.
DR   InterPro; IPR027246; Porin_Euk/Tom40.
DR   PANTHER; PTHR11743; PTHR11743; 1.
DR   Pfam; PF01459; Porin_3; 1.
DR   PROSITE; PS00558; EUKARYOTIC_PORIN; 1.
PE   2: Evidence at transcript level;
KW   Ion transport; Membrane; Mitochondrion; Mitochondrion outer membrane;
KW   Porin; Reference proteome; Transmembrane; Transmembrane beta strand;
KW   Transport.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250"
FT   CHAIN           2..275
FT                   /note="Mitochondrial outer membrane protein porin 3"
FT                   /id="PRO_0000414086"
SQ   SEQUENCE   275 AA;  29892 MW;  4583B544BACFE625 CRC64;
     MAPGLYTDIG KKTRDLLYRD YGTHHKFTLT TCTPEGVTIT AAGTRKNESV FGELQTQLKN
     KKLTVDVKAN SESDLLTTVT VDEFGTPGLK SILSLVVPDQ RSGKLELQYL HEYAGINASV
     GLNSNPMVNL SGVFGSKELS VGVDVAFDTA TSNFTKYNAA LSLTNSDLIA SLHLNNHGDT
     LIASYYHLVK HHSNTAVGAE LSHSFSRNES TLIFGSQHSL DPHTTVKARF NNYGMASALV
     QHEWRPKSLI TISGEVDTKA IEKSTKVGLS LVLKH