VDAC4_ORYSJ
ID VDAC4_ORYSJ Reviewed; 317 AA.
AC Q0JJV1; Q5JLT5;
DT 14-DEC-2011, integrated into UniProtKB/Swiss-Prot.
DT 14-DEC-2011, sequence version 3.
DT 03-AUG-2022, entry version 75.
DE RecName: Full=Mitochondrial outer membrane protein porin 4;
DE AltName: Full=Voltage-dependent anion-selective channel protein 4;
DE Short=OsVDAC4;
GN Name=VDAC4; OrderedLocusNames=Os01g0715500, LOC_Os01g51170;
GN ORFNames=B1131B07.20, P0683B11.1;
OS Oryza sativa subsp. japonica (Rice).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX NCBI_TaxID=39947;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=12447438; DOI=10.1038/nature01184;
RA Sasaki T., Matsumoto T., Yamamoto K., Sakata K., Baba T., Katayose Y.,
RA Wu J., Niimura Y., Cheng Z., Nagamura Y., Antonio B.A., Kanamori H.,
RA Hosokawa S., Masukawa M., Arikawa K., Chiden Y., Hayashi M., Okamoto M.,
RA Ando T., Aoki H., Arita K., Hamada M., Harada C., Hijishita S., Honda M.,
RA Ichikawa Y., Idonuma A., Iijima M., Ikeda M., Ikeno M., Ito S., Ito T.,
RA Ito Y., Ito Y., Iwabuchi A., Kamiya K., Karasawa W., Katagiri S.,
RA Kikuta A., Kobayashi N., Kono I., Machita K., Maehara T., Mizuno H.,
RA Mizubayashi T., Mukai Y., Nagasaki H., Nakashima M., Nakama Y.,
RA Nakamichi Y., Nakamura M., Namiki N., Negishi M., Ohta I., Ono N., Saji S.,
RA Sakai K., Shibata M., Shimokawa T., Shomura A., Song J., Takazaki Y.,
RA Terasawa K., Tsuji K., Waki K., Yamagata H., Yamane H., Yoshiki S.,
RA Yoshihara R., Yukawa K., Zhong H., Iwama H., Endo T., Ito H., Hahn J.H.,
RA Kim H.-I., Eun M.-Y., Yano M., Jiang J., Gojobori T.;
RT "The genome sequence and structure of rice chromosome 1.";
RL Nature 420:312-316(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=16100779; DOI=10.1038/nature03895;
RG International rice genome sequencing project (IRGSP);
RT "The map-based sequence of the rice genome.";
RL Nature 436:793-800(2005).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT "Improvement of the Oryza sativa Nipponbare reference genome using next
RT generation sequence and optical map data.";
RL Rice 6:4-4(2013).
CC -!- FUNCTION: Forms a channel through the mitochondrial outer membrane that
CC allows diffusion of small hydrophilic molecules. The channel adopts an
CC open conformation at low or zero membrane potential and a closed
CC conformation at potentials above 30-40 mV. The open state has a weak
CC anion selectivity whereas the closed state is cation-selective (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000250}.
CC -!- DOMAIN: Consists mainly of membrane-spanning sided beta-sheets.
CC -!- SIMILARITY: Belongs to the eukaryotic mitochondrial porin (TC 1.B.8.1)
CC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAD87377.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=BAD87575.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=BAF05977.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AP003288; BAD87377.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AP003408; BAD87575.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AP008207; BAF05977.2; ALT_SEQ; Genomic_DNA.
DR EMBL; AP014957; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_015649687.1; XM_015794201.1.
DR AlphaFoldDB; Q0JJV1; -.
DR SMR; Q0JJV1; -.
DR STRING; 4530.OS01T0715500-00; -.
DR TCDB; 1.B.8.1.8; the mitochondrial and plastid porin (mpp) family.
DR PaxDb; Q0JJV1; -.
DR PRIDE; Q0JJV1; -.
DR GeneID; 4325576; -.
DR KEGG; osa:4325576; -.
DR eggNOG; KOG3126; Eukaryota.
DR HOGENOM; CLU_069937_1_0_1; -.
DR InParanoid; Q0JJV1; -.
DR OrthoDB; 938262at2759; -.
DR Proteomes; UP000000763; Chromosome 1.
DR Proteomes; UP000059680; Chromosome 1.
DR GO; GO:0005741; C:mitochondrial outer membrane; IBA:GO_Central.
DR GO; GO:0046930; C:pore complex; IEA:UniProtKB-KW.
DR GO; GO:0015288; F:porin activity; IEA:UniProtKB-KW.
DR GO; GO:0008308; F:voltage-gated anion channel activity; IBA:GO_Central.
DR CDD; cd07306; Porin3_VDAC; 1.
DR Gene3D; 2.40.160.10; -; 1.
DR InterPro; IPR023614; Porin_dom_sf.
DR InterPro; IPR001925; Porin_Euk.
DR InterPro; IPR027246; Porin_Euk/Tom40.
DR PANTHER; PTHR11743; PTHR11743; 1.
DR Pfam; PF01459; Porin_3; 1.
PE 3: Inferred from homology;
KW Ion transport; Membrane; Mitochondrion; Mitochondrion outer membrane;
KW Porin; Reference proteome; Transmembrane; Transmembrane beta strand;
KW Transport.
FT CHAIN 1..317
FT /note="Mitochondrial outer membrane protein porin 4"
FT /id="PRO_0000414087"
FT REGION 1..30
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 317 AA; 33757 MW; 464C45792452ABFB CRC64;
MEAETECKVP GVYSETGIPV EDPAPGLNSD VSKKDAPPAV AAPGPGLYFE IGKKARDLLY
KDFHTDQKFT LTTYTNNGVV ITAASTMKDE AIFSEIQTKL KSNNVMLDVK ATSDSQVLTT
ITTEDLGVSG LKQIVSLPFP YQTAGKAELQ YLHDYAGISL GVGLTSKPLV NLSGVFGNKS
VAVGADVAVD TSTGDFTKYD AGLTINNSDL AADLTLNNKG DSLTASYYHL VNKESGTAAG
AELTHSFSTK ENTLSFGMQH ALDPLTTVKA RYNNHGMVSA LIQHEWRPKS FLTLSAEVDT
KAIDKASKVG LSLVLKP
