ID   VDAC6_ORYSJ             Reviewed;         276 AA.
AC   Q10S27; A0A0P0VSU6;
DT   14-DEC-2011, integrated into UniProtKB/Swiss-Prot.
DT   22-AUG-2006, sequence version 1.
DT   03-AUG-2022, entry version 94.
DE   RecName: Full=Mitochondrial outer membrane protein porin 6;
DE   AltName: Full=Voltage-dependent anion-selective channel protein 6;
DE            Short=OsVDAC6;
GN   Name=VDAC6; OrderedLocusNames=Os03g0137500, LOC_Os03g04460;
OS   Oryza sativa subsp. japonica (Rice).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC   Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX   NCBI_TaxID=39947;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=16109971; DOI=10.1101/gr.3869505;
RG   The rice chromosome 3 sequencing consortium;
RA   Buell C.R., Yuan Q., Ouyang S., Liu J., Zhu W., Wang A., Maiti R., Haas B.,
RA   Wortman J., Pertea M., Jones K.M., Kim M., Overton L., Tsitrin T.,
RA   Fadrosh D., Bera J., Weaver B., Jin S., Johri S., Reardon M., Webb K.,
RA   Hill J., Moffat K., Tallon L., Van Aken S., Lewis M., Utterback T.,
RA   Feldblyum T., Zismann V., Iobst S., Hsiao J., de Vazeille A.R.,
RA   Salzberg S.L., White O., Fraser C.M., Yu Y., Kim H., Rambo T., Currie J.,
RA   Collura K., Kernodle-Thompson S., Wei F., Kudrna K., Ammiraju J.S.S.,
RA   Luo M., Goicoechea J.L., Wing R.A., Henry D., Oates R., Palmer M.,
RA   Pries G., Saski C., Simmons J., Soderlund C., Nelson W., de la Bastide M.,
RA   Spiegel L., Nascimento L., Huang E., Preston R., Zutavern T., Palmer L.,
RA   O'Shaughnessy A., Dike S., McCombie W.R., Minx P., Cordum H., Wilson R.,
RA   Jin W., Lee H.R., Jiang J., Jackson S.;
RT   "Sequence, annotation, and analysis of synteny between rice chromosome 3
RT   and diverged grass species.";
RL   Genome Res. 15:1284-1291(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=16100779; DOI=10.1038/nature03895;
RG   International rice genome sequencing project (IRGSP);
RT   "The map-based sequence of the rice genome.";
RL   Nature 436:793-800(2005).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=18089549; DOI=10.1093/nar/gkm978;
RG   The rice annotation project (RAP);
RT   "The rice annotation project database (RAP-DB): 2008 update.";
RL   Nucleic Acids Res. 36:D1028-D1033(2008).
RN   [4]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA   Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA   Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA   Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA   Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT   "Improvement of the Oryza sativa Nipponbare reference genome using next
RT   generation sequence and optical map data.";
RL   Rice 6:4-4(2013).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=12869764; DOI=10.1126/science.1081288;
RG   The rice full-length cDNA consortium;
RT   "Collection, mapping, and annotation of over 28,000 cDNA clones from
RT   japonica rice.";
RL   Science 301:376-379(2003).
CC   -!- FUNCTION: Forms a channel through the mitochondrial outer membrane that
CC       allows diffusion of small hydrophilic molecules. The channel adopts an
CC       open conformation at low or zero membrane potential and a closed
CC       conformation at potentials above 30-40 mV. The open state has a weak
CC       anion selectivity whereas the closed state is cation-selective (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000250}.
CC   -!- DOMAIN: Consists mainly of membrane-spanning sided beta-sheets.
CC   -!- SIMILARITY: Belongs to the eukaryotic mitochondrial porin (TC 1.B.8.1)
CC       family. {ECO:0000305}.
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DR   EMBL; DP000009; ABF93868.1; -; Genomic_DNA.
DR   EMBL; AP008209; BAF10816.1; -; Genomic_DNA.
DR   EMBL; AP014959; BAS82196.1; -; Genomic_DNA.
DR   EMBL; AK060148; BAG87345.1; -; mRNA.
DR   RefSeq; XP_015632202.1; XM_015776716.1.
DR   RefSeq; XP_015632203.1; XM_015776717.1.
DR   AlphaFoldDB; Q10S27; -.
DR   SMR; Q10S27; -.
DR   STRING; 4530.OS03T0137500-01; -.
DR   iPTMnet; Q10S27; -.
DR   PaxDb; Q10S27; -.
DR   PRIDE; Q10S27; -.
DR   EnsemblPlants; Os03t0137500-01; Os03t0137500-01; Os03g0137500.
DR   EnsemblPlants; Os03t0137500-03; Os03t0137500-03; Os03g0137500.
DR   GeneID; 4331551; -.
DR   Gramene; Os03t0137500-01; Os03t0137500-01; Os03g0137500.
DR   Gramene; Os03t0137500-03; Os03t0137500-03; Os03g0137500.
DR   KEGG; osa:4331551; -.
DR   eggNOG; KOG3126; Eukaryota.
DR   HOGENOM; CLU_069937_0_0_1; -.
DR   InParanoid; Q10S27; -.
DR   OMA; PWSWRLN; -.
DR   OrthoDB; 938262at2759; -.
DR   Proteomes; UP000000763; Chromosome 3.
DR   Proteomes; UP000059680; Chromosome 3.
DR   ExpressionAtlas; Q10S27; baseline and differential.
DR   Genevisible; Q10S27; OS.
DR   GO; GO:0005741; C:mitochondrial outer membrane; IBA:GO_Central.
DR   GO; GO:0046930; C:pore complex; IEA:UniProtKB-KW.
DR   GO; GO:0015288; F:porin activity; IEA:UniProtKB-KW.
DR   GO; GO:0008308; F:voltage-gated anion channel activity; IBA:GO_Central.
DR   GO; GO:0009617; P:response to bacterium; IEA:EnsemblPlants.
DR   CDD; cd07306; Porin3_VDAC; 1.
DR   Gene3D; 2.40.160.10; -; 1.
DR   InterPro; IPR023614; Porin_dom_sf.
DR   InterPro; IPR001925; Porin_Euk.
DR   InterPro; IPR027246; Porin_Euk/Tom40.
DR   PANTHER; PTHR11743; PTHR11743; 1.
DR   Pfam; PF01459; Porin_3; 1.
PE   2: Evidence at transcript level;
KW   Ion transport; Membrane; Mitochondrion; Mitochondrion outer membrane;
KW   Porin; Reference proteome; Transmembrane; Transmembrane beta strand;
KW   Transport.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250"
FT   CHAIN           2..276
FT                   /note="Mitochondrial outer membrane protein porin 6"
FT                   /id="PRO_0000414089"
SQ   SEQUENCE   276 AA;  29683 MW;  6343CB6AD590145A CRC64;
     MSKGPAPFLN IGKRAKDLLY KDYNFDQKFS LTTTSNSGLG LTATGVKIDE LFIGDIQTQH
     KSGKTTVDVK IDSESRVSTT VTVDEALTGL KTSFSFRVPD QKSGKLDLQY LHDHFALNST
     IGLTSTPLIE LAATIGTNEL SAGAEVGFDS TSASVTKYNS GICYNKHDFS AAVLLADKGE
     TLKASYIHTF NETNGATVAA EVTHKLKTKE NYFTIGSSHA IDSSTLLKTR FSNGGKVGVL
     CQHEWRPKST VSISAEYDPK VVSSPSRFGV AIALKP