ID   VDAC_CAEEL              Reviewed;         283 AA.
AC   Q21752;
DT   15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT   27-MAY-2002, sequence version 2.
DT   03-AUG-2022, entry version 135.
DE   RecName: Full=Probable voltage-dependent anion-selective channel;
GN   Name=vdac-1 {ECO:0000312|WormBase:R05G6.7};
GN   ORFNames=R05G6.7 {ECO:0000312|WormBase:R05G6.7};
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
RN   [2]
RP   FUNCTION, AND DISRUPTION PHENOTYPE.
RX   PubMed=25190516; DOI=10.15252/embj.201489039;
RA   Ackema K.B., Hench J., Boeckler S., Wang S.C., Sauder U., Mergentaler H.,
RA   Westermann B., Bard F., Frank S., Spang A.;
RT   "The small GTPase Arf1 modulates mitochondrial morphology and function.";
RL   EMBO J. 33:2659-2675(2014).
CC   -!- FUNCTION: Forms a channel through the cell membrane that allows
CC       diffusion of small hydrophilic molecules (By similarity). Plays a role
CC       in maintaining mitochondrial morphology (PubMed:25190516).
CC       {ECO:0000250|UniProtKB:P21796, ECO:0000269|PubMed:25190516}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion outer membrane
CC       {ECO:0000250|UniProtKB:P21796}; Multi-pass membrane protein
CC       {ECO:0000250|UniProtKB:P21796}.
CC   -!- DOMAIN: Consists mainly of membrane-spanning sided beta-sheets.
CC       {ECO:0000250|UniProtKB:P21796}.
CC   -!- DISRUPTION PHENOTYPE: RNAi-mediated knockdown results in a hyper-
CC       connected mitochondrial network in body wall muscle cells.
CC       {ECO:0000269|PubMed:25190516}.
CC   -!- SIMILARITY: Belongs to the eukaryotic mitochondrial porin family.
CC       {ECO:0000305}.
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DR   EMBL; BX284604; CCD71556.1; -; Genomic_DNA.
DR   PIR; T29355; T29355.
DR   RefSeq; NP_501211.1; NM_068810.5.
DR   AlphaFoldDB; Q21752; -.
DR   SMR; Q21752; -.
DR   BioGRID; 42642; 34.
DR   IntAct; Q21752; 1.
DR   STRING; 6239.R05G6.7; -.
DR   EPD; Q21752; -.
DR   PaxDb; Q21752; -.
DR   PeptideAtlas; Q21752; -.
DR   EnsemblMetazoa; R05G6.7.1; R05G6.7.1; WBGene00019900.
DR   GeneID; 177524; -.
DR   KEGG; cel:CELE_R05G6.7; -.
DR   UCSC; R05G6.7.1; c. elegans.
DR   CTD; 177524; -.
DR   WormBase; R05G6.7; CE29443; WBGene00019900; vdac-1.
DR   eggNOG; KOG3126; Eukaryota.
DR   GeneTree; ENSGT00950000182869; -.
DR   HOGENOM; CLU_044399_2_0_1; -.
DR   InParanoid; Q21752; -.
DR   OMA; ITLTEKW; -.
DR   OrthoDB; 938262at2759; -.
DR   PhylomeDB; Q21752; -.
DR   Reactome; R-CEL-5205685; PINK1-PRKN Mediated Mitophagy.
DR   Reactome; R-CEL-70268; Pyruvate metabolism.
DR   PRO; PR:Q21752; -.
DR   Proteomes; UP000001940; Chromosome IV.
DR   Bgee; WBGene00019900; Expressed in embryo and 4 other tissues.
DR   GO; GO:0005741; C:mitochondrial outer membrane; IBA:GO_Central.
DR   GO; GO:0005739; C:mitochondrion; IDA:WormBase.
DR   GO; GO:0046930; C:pore complex; IEA:UniProtKB-KW.
DR   GO; GO:0015288; F:porin activity; IEA:UniProtKB-KW.
DR   GO; GO:0008308; F:voltage-gated anion channel activity; IBA:GO_Central.
DR   GO; GO:0007005; P:mitochondrion organization; IMP:WormBase.
DR   GO; GO:0042048; P:olfactory behavior; IMP:WormBase.
DR   CDD; cd07306; Porin3_VDAC; 1.
DR   Gene3D; 2.40.160.10; -; 1.
DR   InterPro; IPR023614; Porin_dom_sf.
DR   InterPro; IPR001925; Porin_Euk.
DR   InterPro; IPR027246; Porin_Euk/Tom40.
DR   InterPro; IPR030277; VDAC2.
DR   PANTHER; PTHR11743; PTHR11743; 1.
DR   PANTHER; PTHR11743:SF12; PTHR11743:SF12; 1.
DR   Pfam; PF01459; Porin_3; 1.
DR   PRINTS; PR00185; EUKARYTPORIN.
PE   3: Inferred from homology;
KW   Ion transport; Membrane; Mitochondrion; Mitochondrion outer membrane;
KW   Porin; Reference proteome; Transmembrane; Transmembrane beta strand;
KW   Transport.
FT   CHAIN           1..283
FT                   /note="Probable voltage-dependent anion-selective channel"
FT                   /id="PRO_0000050521"
SQ   SEQUENCE   283 AA;  29961 MW;  060141EEA5060290 CRC64;
     MAPPTFADLG KSAKDLFNKG YNFGFLKIDS TTRAGDNKEV EFKSAASHNI GSGKLGGNLD
     VKYKIPQYGI TLTEKWNTEN QLGTVIEVNE QFGRGLKVTL DSLYAPHAGK RSGKVKLDWA
     LPTARVTADV GVTSAPVINA AGVFSRDGWL IGAAATFDSS SNKLAATSLA FGHSTPQYTL
     HSFVINSTDF GASLYHKVAS NVEVGTQLGW KVGGNGADYA LATKYAPSRD LTVRAKVNSS
     SQVAVAATHS LSPALKLTLS TQFNLAANDA HKFGLGLEFD PSN