VDAC_CANAL
ID VDAC_CANAL Reviewed; 282 AA.
AC P83781; A0A1D8PD67; Q59VQ1; Q59VU7;
DT 04-JAN-2005, integrated into UniProtKB/Swiss-Prot.
DT 19-OCT-2011, sequence version 2.
DT 03-AUG-2022, entry version 70.
DE RecName: Full=Mitochondrial outer membrane protein porin;
DE AltName: Full=Cytoplasmic antigenic protein 4;
GN Name=POR1; OrderedLocusNames=CAALFM_C104100CA;
GN ORFNames=CaO19.1042, CaO19.8644;
OS Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=237561;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA Scherer S.;
RT "The diploid genome sequence of Candida albicans.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA Chibana H., Nantel A., Magee P.T.;
RT "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT on the eight chromosomes.";
RL Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT specific measurements and provides a simple model for repeat and indel
RT structure.";
RL Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
RN [4]
RP PROTEIN SEQUENCE OF 98-105, AND ANTIGENICITY.
RC STRAIN=SC5314 / ATCC MYA-2876; TISSUE=Protoplast;
RX PubMed=15378761; DOI=10.1002/pmic.200400903;
RA Pitarch A., Abian J., Carrascal M., Sanchez M., Nombela C., Gil C.;
RT "Proteomics-based identification of novel Candida albicans antigens for
RT diagnosis of systemic candidiasis in patients with underlying hematological
RT malignancies.";
RL Proteomics 4:3084-3106(2004).
CC -!- FUNCTION: Forms a channel through the cell membrane that allows
CC diffusion of small hydrophilic molecules. The channel adopts an open
CC conformation at low or zero membrane potential and a closed
CC conformation at potentials above 30-40 mV. The open state has a weak
CC anion selectivity whereas the closed state is cation-selective (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000250}.
CC -!- DOMAIN: Consists mainly of membrane-spanning sided beta-sheets.
CC {ECO:0000250}.
CC -!- MISCELLANEOUS: Has antigenic properties. Elicits a specific immune
CC response in systemic candidiasis human patients undergoing malignant
CC hematological disorders.
CC -!- SIMILARITY: Belongs to the eukaryotic mitochondrial porin family.
CC {ECO:0000305}.
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DR EMBL; CP017623; AOW26085.1; -; Genomic_DNA.
DR RefSeq; XP_713647.1; XM_708554.2.
DR AlphaFoldDB; P83781; -.
DR SMR; P83781; -.
DR BioGRID; 1227761; 3.
DR STRING; 237561.P83781; -.
DR COMPLUYEAST-2DPAGE; P83781; -.
DR PRIDE; P83781; -.
DR GeneID; 3644698; -.
DR KEGG; cal:CAALFM_C104100CA; -.
DR CGD; CAL0000182381; POR1.
DR VEuPathDB; FungiDB:C1_04100C_A; -.
DR eggNOG; KOG3126; Eukaryota.
DR HOGENOM; CLU_044399_1_0_1; -.
DR InParanoid; P83781; -.
DR OMA; PWSWRLN; -.
DR OrthoDB; 938262at2759; -.
DR PRO; PR:P83781; -.
DR Proteomes; UP000000559; Chromosome 1.
DR GO; GO:1903561; C:extracellular vesicle; IDA:CGD.
DR GO; GO:0016020; C:membrane; IDA:CGD.
DR GO; GO:0005741; C:mitochondrial outer membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IDA:CGD.
DR GO; GO:0046930; C:pore complex; IEA:UniProtKB-KW.
DR GO; GO:0015288; F:porin activity; IEA:UniProtKB-KW.
DR GO; GO:0008308; F:voltage-gated anion channel activity; IBA:GO_Central.
DR CDD; cd07306; Porin3_VDAC; 1.
DR Gene3D; 2.40.160.10; -; 1.
DR InterPro; IPR023614; Porin_dom_sf.
DR InterPro; IPR001925; Porin_Euk.
DR InterPro; IPR027246; Porin_Euk/Tom40.
DR PANTHER; PTHR11743; PTHR11743; 1.
DR Pfam; PF01459; Porin_3; 1.
DR PRINTS; PR00185; EUKARYTPORIN.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Ion transport; Membrane; Mitochondrion;
KW Mitochondrion outer membrane; Porin; Reference proteome; Transmembrane;
KW Transmembrane beta strand; Transport.
FT CHAIN 1..282
FT /note="Mitochondrial outer membrane protein porin"
FT /id="PRO_0000089304"
SQ SEQUENCE 282 AA; 29767 MW; 09EAA6DE4C6287CF CRC64;
MAPAAYSDLS KASNDLINKD FYHLSTAAVD VKTVAPNGVT FTVKGKTTKD DTISASVDAK
YLDKATGLTL TQGWNNANAL NTKIELSELL TPGLKGELDT SVVPNGARNA KLNFFYQQSA
VNARLFFDLL KGPIATADLV VAHDGFTAGA ELGYDISSAK VNKYSVGVGY ANLNYGLAAT
ATSNLSVFSA AYFHKVSPLV QVGAKATWDS IKSSNVNVEF ATKYALDNTS FIKAKIADSG
LTALSYTQEL RPGVKLGLGA SFDALKLAEP VHKLGFSLSF AA