ID   VDAC_NEUCR              Reviewed;         283 AA.
AC   P07144; Q7RVC5;
DT   01-APR-1988, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1988, sequence version 1.
DT   03-AUG-2022, entry version 133.
DE   RecName: Full=Mitochondrial outer membrane protein porin;
GN   ORFNames=B7H23.070, NCU04304;
OS   Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS   FGSC 987).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX   NCBI_TaxID=367110;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=2960519; DOI=10.1002/j.1460-2075.1987.tb02553.x;
RA   Kleene R., Pfanner N., Pfaller R., Link T.A., Sebald W., Neupert W.,
RA   Tropschug M.;
RT   "Mitochondrial porin of Neurospora crassa: cDNA cloning, in vitro
RT   expression and import into mitochondria.";
RL   EMBO J. 6:2627-2633(1987).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=12655011; DOI=10.1093/nar/gkg293;
RA   Mannhaupt G., Montrone C., Haase D., Mewes H.-W., Aign V., Hoheisel J.D.,
RA   Fartmann B., Nyakatura G., Kempken F., Maier J., Schulte U.;
RT   "What's in the genome of a filamentous fungus? Analysis of the Neurospora
RT   genome sequence.";
RL   Nucleic Acids Res. 31:1944-1954(2003).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=12712197; DOI=10.1038/nature01554;
RA   Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA   Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA   Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA   Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA   Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA   Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D.,
RA   Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA   Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D.,
RA   Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA   Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA   DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA   Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA   Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I.,
RA   Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT   "The genome sequence of the filamentous fungus Neurospora crassa.";
RL   Nature 422:859-868(2003).
CC   -!- FUNCTION: Forms a channel through the cell membrane that allows
CC       diffusion of small hydrophilic molecules. The channel adopts an open
CC       conformation at low or zero membrane potential and a closed
CC       conformation at potentials above 30-40 mV. The open state has a weak
CC       anion selectivity whereas the closed state is cation-selective.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion outer membrane.
CC   -!- DOMAIN: Consists mainly of membrane-spanning sided beta-sheets.
CC   -!- SIMILARITY: Belongs to the eukaryotic mitochondrial porin family.
CC       {ECO:0000305}.
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DR   EMBL; X05824; CAA29264.1; -; mRNA.
DR   EMBL; BX294026; CAD71033.1; -; Genomic_DNA.
DR   EMBL; CM002240; EAA31714.1; -; Genomic_DNA.
DR   PIR; S07195; MMNCP.
DR   RefSeq; XP_960950.1; XM_955857.3.
DR   AlphaFoldDB; P07144; -.
DR   SMR; P07144; -.
DR   STRING; 5141.EFNCRP00000003947; -.
DR   TCDB; 1.B.8.1.20; the mitochondrial and plastid porin (mpp) family.
DR   PRIDE; P07144; -.
DR   EnsemblFungi; EAA31714; EAA31714; NCU04304.
DR   GeneID; 3877116; -.
DR   KEGG; ncr:NCU04304; -.
DR   VEuPathDB; FungiDB:NCU04304; -.
DR   HOGENOM; CLU_044399_0_0_1; -.
DR   InParanoid; P07144; -.
DR   OMA; PWSWRLN; -.
DR   Proteomes; UP000001805; Chromosome 2, Linkage Group V.
DR   GO; GO:0005741; C:mitochondrial outer membrane; IBA:GO_Central.
DR   GO; GO:0046930; C:pore complex; IEA:UniProtKB-KW.
DR   GO; GO:0015288; F:porin activity; IEA:UniProtKB-KW.
DR   GO; GO:0008308; F:voltage-gated anion channel activity; IBA:GO_Central.
DR   CDD; cd07306; Porin3_VDAC; 1.
DR   Gene3D; 2.40.160.10; -; 1.
DR   InterPro; IPR023614; Porin_dom_sf.
DR   InterPro; IPR001925; Porin_Euk.
DR   InterPro; IPR027246; Porin_Euk/Tom40.
DR   PANTHER; PTHR11743; PTHR11743; 1.
DR   Pfam; PF01459; Porin_3; 1.
DR   PRINTS; PR00185; EUKARYTPORIN.
DR   PROSITE; PS00558; EUKARYOTIC_PORIN; 1.
PE   2: Evidence at transcript level;
KW   Ion transport; Membrane; Mitochondrion; Mitochondrion outer membrane;
KW   Porin; Reference proteome; Transmembrane; Transmembrane beta strand;
KW   Transport.
FT   CHAIN           1..283
FT                   /note="Mitochondrial outer membrane protein porin"
FT                   /id="PRO_0000050522"
SQ   SEQUENCE   283 AA;  30000 MW;  12C23ABBFF89C519 CRC64;
     MAVPAFSDIA KSANDLLNKD FYHLAAGTIE VKSNTPNNVA FKVTGKSTHD KVTSGALEGK
     FTDKPNGLTV TQTWNTANAL ETKVEMADNL AKGLKAEGIF SFLPATNARG AKFNLHFKQS
     NFHGRAFFDL LKGPTANIDA IVGHEGFLAG ASAGYDVQKA AITGYSAAVG YHAPTYSAAI
     TATDNLSVFS ASYYHKVNSQ VEAGSKATWN SKTGNTVGLE VATKYRIDPV SFVKGKINDR
     GVAAIAYNVL LREGVTLGVG ASFDTQKLDQ ATHKVGTSFT FES