ID   VDLC_HELPJ              Reviewed;         271 AA.
AC   Q9ZKW1;
DT   11-JAN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   03-AUG-2022, entry version 102.
DE   RecName: Full=Probable short-chain type dehydrogenase/reductase VdlC;
DE            EC=1.-.-.-;
GN   Name=vdlC; OrderedLocusNames=jhp_0823;
OS   Helicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99).
OC   Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
OC   Helicobacteraceae; Helicobacter.
OX   NCBI_TaxID=85963;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=J99 / ATCC 700824;
RX   PubMed=9923682; DOI=10.1038/16495;
RA   Alm R.A., Ling L.-S.L., Moir D.T., King B.L., Brown E.D., Doig P.C.,
RA   Smith D.R., Noonan B., Guild B.C., deJonge B.L., Carmel G., Tummino P.J.,
RA   Caruso A., Uria-Nickelsen M., Mills D.M., Ives C., Gibson R., Merberg D.,
RA   Mills S.D., Jiang Q., Taylor D.E., Vovis G.F., Trust T.J.;
RT   "Genomic sequence comparison of two unrelated isolates of the human gastric
RT   pathogen Helicobacter pylori.";
RL   Nature 397:176-180(1999).
CC   -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC       family. {ECO:0000305}.
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DR   EMBL; AE001439; AAD06395.1; -; Genomic_DNA.
DR   PIR; A71885; A71885.
DR   AlphaFoldDB; Q9ZKW1; -.
DR   SMR; Q9ZKW1; -.
DR   STRING; 85963.jhp_0823; -.
DR   EnsemblBacteria; AAD06395; AAD06395; jhp_0823.
DR   KEGG; hpj:jhp_0823; -.
DR   eggNOG; COG0300; Bacteria.
DR   OMA; QMDVTDR; -.
DR   Proteomes; UP000000804; Chromosome.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR020904; Sc_DH/Rdtase_CS.
DR   InterPro; IPR002347; SDR_fam.
DR   Pfam; PF00106; adh_short; 1.
DR   PRINTS; PR00081; GDHRDH.
DR   PRINTS; PR00080; SDRFAMILY.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   PROSITE; PS00061; ADH_SHORT; 1.
PE   3: Inferred from homology;
KW   Oxidoreductase.
FT   CHAIN           1..271
FT                   /note="Probable short-chain type dehydrogenase/reductase
FT                   VdlC"
FT                   /id="PRO_0000054806"
FT   ACT_SITE        142
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10001"
FT   BINDING         1..25
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /evidence="ECO:0000250"
FT   BINDING         129
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   271 AA;  30086 MW;  23172021E1525288 CRC64;
     MAVITGASSG IGLECVLMLL NQGYKVYALS RHATLCVALN HALCECVDID VSDSNALKEV
     FLNISAKEDH CDVLINSAGY GVFGSVEDTP IEEVKKQFSV NFFALCEVVQ LCLPLLKNKP
     YSKIFNLSSI AGRVSMLFLG HYSASKHALE AYSDALRLEL KPFNVQVCLI EPGPVKSNWE
     KTAFENDERK DSVYALEVNA AKSFYSGVYQ KALNAKEVAQ KIVFLSMSHK IKARYLIGLK
     TQLLLALYQI LPSSWYDSLF RLVVLGRKRD A