VDLC_HELPY
ID VDLC_HELPY Reviewed; 284 AA.
AC O05730;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1997, sequence version 2.
DT 03-AUG-2022, entry version 106.
DE RecName: Full=Probable short-chain type dehydrogenase/reductase VdlC;
DE EC=1.-.-.-;
GN Name=vdlC; OrderedLocusNames=HP_0890;
OS Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori).
OC Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
OC Helicobacteraceae; Helicobacter.
OX NCBI_TaxID=85962;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 49503 / 60190;
RX PubMed=9139899; DOI=10.1128/jb.179.9.2852-2856.1997;
RA Cao P., Cover T.L.;
RT "High-level genetic diversity in the vapD chromosomal region of
RT Helicobacter pylori.";
RL J. Bacteriol. 179:2852-2856(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700392 / 26695;
RX PubMed=9252185; DOI=10.1038/41483;
RA Tomb J.-F., White O., Kerlavage A.R., Clayton R.A., Sutton G.G.,
RA Fleischmann R.D., Ketchum K.A., Klenk H.-P., Gill S.R., Dougherty B.A.,
RA Nelson K.E., Quackenbush J., Zhou L., Kirkness E.F., Peterson S.N.,
RA Loftus B.J., Richardson D.L., Dodson R.J., Khalak H.G., Glodek A.,
RA McKenney K., FitzGerald L.M., Lee N., Adams M.D., Hickey E.K., Berg D.E.,
RA Gocayne J.D., Utterback T.R., Peterson J.D., Kelley J.M., Cotton M.D.,
RA Weidman J.F., Fujii C., Bowman C., Watthey L., Wallin E., Hayes W.S.,
RA Borodovsky M., Karp P.D., Smith H.O., Fraser C.M., Venter J.C.;
RT "The complete genome sequence of the gastric pathogen Helicobacter
RT pylori.";
RL Nature 388:539-547(1997).
CC -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAD07938.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; U94318; AAC45243.1; -; Genomic_DNA.
DR EMBL; AE000511; AAD07938.1; ALT_INIT; Genomic_DNA.
DR PIR; B64631; B64631.
DR PIR; T09452; T09452.
DR RefSeq; NP_207683.1; NC_000915.1.
DR AlphaFoldDB; O05730; -.
DR SMR; O05730; -.
DR STRING; 85962.C694_04570; -.
DR PaxDb; O05730; -.
DR EnsemblBacteria; AAD07938; AAD07938; HP_0890.
DR KEGG; hpy:HP_0890; -.
DR PATRIC; fig|85962.8.peg.922; -.
DR eggNOG; COG0300; Bacteria.
DR PhylomeDB; O05730; -.
DR Proteomes; UP000000429; Chromosome.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020904; Sc_DH/Rdtase_CS.
DR InterPro; IPR002347; SDR_fam.
DR Pfam; PF00106; adh_short; 1.
DR PRINTS; PR00081; GDHRDH.
DR PRINTS; PR00080; SDRFAMILY.
DR SUPFAM; SSF51735; SSF51735; 1.
DR PROSITE; PS00061; ADH_SHORT; 1.
PE 3: Inferred from homology;
KW Oxidoreductase; Reference proteome.
FT CHAIN 1..284
FT /note="Probable short-chain type dehydrogenase/reductase
FT VdlC"
FT /id="PRO_0000054805"
FT ACT_SITE 153
FT /note="Proton acceptor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU10001"
FT BINDING 10..36
FT /ligand="NAD(+)"
FT /ligand_id="ChEBI:CHEBI:57540"
FT /evidence="ECO:0000250"
FT BINDING 140
FT /ligand="substrate"
FT /evidence="ECO:0000250"
FT CONFLICT 71
FT /note="V -> A (in Ref. 1; AAC45243)"
FT /evidence="ECO:0000305"
FT CONFLICT 80..81
FT /note="KY -> DH (in Ref. 1; AAC45243)"
FT /evidence="ECO:0000305"
FT CONFLICT 132
FT /note="H -> Y (in Ref. 1; AAC45243)"
FT /evidence="ECO:0000305"
FT CONFLICT 202..205
FT /note="SEDS -> NKNG (in Ref. 1; AAC45243)"
FT /evidence="ECO:0000305"
FT CONFLICT 212
FT /note="N -> D (in Ref. 1; AAC45243)"
FT /evidence="ECO:0000305"
FT CONFLICT 216
FT /note="S -> T (in Ref. 1; AAC45243)"
FT /evidence="ECO:0000305"
FT CONFLICT 219..220
FT /note="SG -> AS (in Ref. 1; AAC45243)"
FT /evidence="ECO:0000305"
FT CONFLICT 224
FT /note="N -> K (in Ref. 1; AAC45243)"
FT /evidence="ECO:0000305"
FT CONFLICT 227..228
FT /note="SP -> NA (in Ref. 1)"
FT /evidence="ECO:0000305"
FT CONFLICT 230
FT /note="A -> E (in Ref. 1)"
FT /evidence="ECO:0000305"
FT CONFLICT 262
FT /note="Q -> R (in Ref. 1; AAC45243)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 284 AA; 31415 MW; 7B949DAF34DDEB5B CRC64;
MGVGEKKESQ KVAIITGASS GIGLECALML LDQGYKVYAL SRHATLCVAL NHALCESVDI
DVSDSNALKE VFSNISAKEK YCDVLINSAG YGVFGSVEDT PIEEVKKQFS VNFFALCEVV
QFCLPLLKNK PHSKIFNLSS IAGRVSMLFL GHYSASKHAL EAYSDALRLE LKPFNVQVCL
IEPGPVKSNW EKTAFSVENF ESEDSLYALE VNAAKSFYSG VYQNALSPKA VAQKIVFLSM
SQKIKARYLI GLKTQLLLAL YQILPSSWYD SLFRLIVLKR KRDA
