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VDTG1_BYSSP
ID   VDTG1_BYSSP             Reviewed;         555 AA.
AC   A0A443HJZ5;
DT   16-OCT-2019, integrated into UniProtKB/Swiss-Prot.
DT   08-MAY-2019, sequence version 1.
DT   25-MAY-2022, entry version 13.
DE   RecName: Full=MFS-type transporter VdtG {ECO:0000303|PubMed:31304040};
DE   AltName: Full=Viriditoxin biosynthesis cluster protein G {ECO:0000303|PubMed:31304040};
GN   Name=VdtG {ECO:0000303|PubMed:31304040}; ORFNames=C8Q69DRAFT_488624;
OS   Byssochlamys spectabilis (Paecilomyces variotii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Thermoascaceae; Paecilomyces.
OX   NCBI_TaxID=264951;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CBS 101075;
RX   PubMed=30619145; DOI=10.3389/fmicb.2018.03058;
RA   Urquhart A.S., Mondo S.J., Maekelae M.R., Hane J.K., Wiebenga A., He G.,
RA   Mihaltcheva S., Pangilinan J., Lipzen A., Barry K., de Vries R.P.,
RA   Grigoriev I.V., Idnurm A.;
RT   "Genomic and genetic insights into a cosmopolitan fungus, Paecilomyces
RT   variotii (Eurotiales).";
RL   Front. Microbiol. 9:3058-3058(2018).
RN   [2]
RP   IDENTIFICATION, FUNCTION, DISRUPTION PHENOTYPE, AND SUBCELLULAR LOCATION.
RX   PubMed=31304040; DOI=10.1186/s40694-019-0072-y;
RA   Urquhart A.S., Hu J., Chooi Y.H., Idnurm A.;
RT   "The fungal gene cluster for biosynthesis of the antibacterial agent
RT   viriditoxin.";
RL   Fungal Biol. Biotechnol. 6:2-2(2019).
CC   -!- FUNCTION: MFS-type transporter; part of the gene cluster that mediates
CC       the biosynthesis of viriditoxin, one of the 'classical' secondary
CC       metabolites produced by fungi and that has antibacterial activity
CC       (PubMed:31304040). Is not essential for viriditoxin production
CC       (PubMed:31304040). {ECO:0000269|PubMed:31304040}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000269|PubMed:31304040}; Multi-pass membrane protein
CC       {ECO:0000255}.
CC   -!- DISRUPTION PHENOTYPE: Does not affect the production of viriditoxin but
CC       leads to a sporulation defect. {ECO:0000269|PubMed:31304040}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily. TCR/Tet
CC       family. {ECO:0000305}.
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DR   EMBL; RCNU01000014; RWQ92172.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A443HJZ5; -.
DR   SMR; A0A443HJZ5; -.
DR   Proteomes; UP000283841; Unassembled WGS sequence.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   Gene3D; 1.20.1250.20; -; 1.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   Pfam; PF07690; MFS_1; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   PROSITE; PS50850; MFS; 1.
PE   3: Inferred from homology;
KW   Endoplasmic reticulum; Glycoprotein; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..555
FT                   /note="MFS-type transporter VdtG"
FT                   /id="PRO_0000448347"
FT   TRANSMEM        30..50
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        71..91
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        101..121
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        132..152
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        162..182
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        190..210
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        232..252
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        262..282
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        304..324
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        337..357
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        364..384
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        393..413
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        425..445
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        497..517
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          1..20
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          528..555
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        4
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT   CARBOHYD        122
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT   CARBOHYD        185
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT   CARBOHYD        329
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
SQ   SEQUENCE   555 AA;  58308 MW;  7CCCE50649B5A0D7 CRC64;
     MNGNGTADKP GPPGGKPFGP GMGPPIQYPT GFKLYSIMTG LYLASFLTAL DRTVLVVAIP
     QITDHFNSID DIGWYGSAYL LTFCAFQLLF GKIYSFYNPK WVFLSAVLIF EIGSAICGAA
     PNSTALIIGR AIAGLGSSGI FGGSVIITFF TVPLHQRPIY TGIAGVIFAL ASSVGPLIGG
     GFTNNVSWRW CFYINLPVGA LTVVTILLFL NLPPARKAGT PLREQLLQMD PLGNLCLIPG
     IICLLLAIQW GGSTYAWSNG RIVALLVLAG VLLIAFVGVQ LWLQDKGTIP PRVMKQRSIA
     AGMAFTICVT AGFMSFNYYL PIWFQAIKNA SSFHSGVMML PTVISSGVAS LACGFIIHRV
     GYYTPFMIGG SVLMAIGAGL LTTFTPTTEH PKWIGYQVLW ALGCGMSMQQ ASLAAQTVLP
     KPDAPIGISL IFFSQSLGGS VFLAVDDSIY SNRLAAKLGS IPNLPQSALT NTGATNIRNL
     VAPQYLGRLL GGYNDALMDV FRVAVASSCA CVVAAAFMEW KNVRAAKAAG PGGPGGPGGP
     GGPGGPEGLR GGNKV
 
 
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