ID   VE5_BPV1                Reviewed;          44 AA.
AC   P0CK45; P06928;
DT   21-MAR-2012, integrated into UniProtKB/Swiss-Prot.
DT   21-MAR-2012, sequence version 1.
DT   02-DEC-2020, entry version 25.
DE   RecName: Full=Protein E5;
GN   Name=E5;
OS   Bovine papillomavirus type 1.
OC   Viruses; Monodnaviria; Shotokuvirae; Cossaviricota; Papovaviricetes;
OC   Zurhausenvirales; Papillomaviridae; Firstpapillomavirinae;
OC   Deltapapillomavirus.
OX   NCBI_TaxID=337052;
OH   NCBI_TaxID=9913; Bos taurus (Bovine).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=6289124; DOI=10.1038/299529a0;
RA   Chen E.Y., Howley P.M., Levinson A.D., Seeburg P.H.;
RT   "The primary structure and genetic organization of the bovine
RT   papillomavirus type 1 genome.";
RL   Nature 299:529-534(1982).
RN   [2]
RP   COMPARATIVE ANALYSIS OF HUMAN TYPE 1A AND BOVINE TYPE 1 GENOMES.
RX   PubMed=6302319; DOI=10.1128/jvi.46.2.557-566.1983;
RA   Danos O., Engel L.W., Chen E.Y., Yaniv M., Howley P.M.;
RT   "Comparative analysis of the human type 1a and bovine type 1 papillomavirus
RT   genomes.";
RL   J. Virol. 46:557-566(1983).
RN   [3]
RP   IDENTIFICATION OF PROTEIN.
RX   PubMed=3014660; DOI=10.1126/science.3014660;
RA   Schlegel R., Wade-Glass M., Rabson M.S., Yang Y.C.;
RT   "The E5 transforming gene of bovine papillomavirus encodes a small,
RT   hydrophobic polypeptide.";
RL   Science 233:464-467(1986).
RN   [4]
RP   MUTAGENESIS.
RX   PubMed=2552177; DOI=10.1128/jvi.63.11.4962-4964.1989;
RA   Rawls J.A., Loewenstein P.M., Green M.;
RT   "Mutational analysis of bovine papillomavirus type 1 E5 peptide domains
RT   involved in induction of cellular DNA synthesis.";
RL   J. Virol. 63:4962-4964(1989).
RN   [5]
RP   INTERACTION WITH A CELLULAR PROTEIN.
RX   PubMed=1688529; DOI=10.1002/j.1460-2075.1990.tb08089.x;
RA   Goldstein D.J., Schlegel R.;
RT   "The E5 oncoprotein of bovine papillomavirus binds to a 16 kd cellular
RT   protein.";
RL   EMBO J. 9:137-146(1990).
RN   [6]
RP   ACTIVATION OF PDGF RECEPTOR.
RX   PubMed=1849073; DOI=10.1002/j.1460-2075.1991.tb08017.x;
RA   Petti L., Nilson L.A., Dimaio D.;
RT   "Activation of the platelet-derived growth factor receptor by the bovine
RT   papillomavirus E5 transforming protein.";
RL   EMBO J. 10:845-855(1991).
CC   -!- FUNCTION: E5 can induce cellular DNA synthesis. It seems to interact
CC       with a 16 kDa cellular protein. E5 seems to activate the PDGF receptor.
CC   -!- SUBUNIT: Dimer or monomer.
CC   -!- INTERACTION:
CC       P0CK45; P27449: ATP6V0C; Xeno; NbExp=2; IntAct=EBI-7015490, EBI-721179;
CC       P0CK45; P09619: PDGFRB; Xeno; NbExp=2; IntAct=EBI-7015490, EBI-641237;
CC   -!- SUBCELLULAR LOCATION: Host membrane; Peripheral membrane protein.
CC   -!- SIMILARITY: Belongs to the papillomaviridae E5 protein family.
CC       {ECO:0000305}.
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DR   EMBL; X02346; CAB46513.1; -; Genomic_DNA.
DR   PIR; G31169; W5WLEB.
DR   RefSeq; NP_056742.1; NC_001522.1.
DR   IntAct; P0CK45; 2.
DR   MINT; P0CK45; -.
DR   GeneID; 1489021; -.
DR   KEGG; vg:1489021; -.
DR   Proteomes; UP000006567; Genome.
DR   GO; GO:0033644; C:host cell membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0019087; P:transformation of host cell by virus; IDA:CACAO.
DR   InterPro; IPR012555; EPV_E5.
DR   Pfam; PF08135; EPV_E5; 1.
DR   PIRSF; PIRSF003401; EPV_E5; 1.
PE   1: Evidence at protein level;
KW   Early protein; Host membrane; Membrane; Oncogene; Reference proteome.
FT   CHAIN           1..44
FT                   /note="Protein E5"
FT                   /id="PRO_0000133286"
FT   REGION          32..44
FT                   /note="Cellular DNA synthesis induction"
SQ   SEQUENCE   44 AA;  5210 MW;  0E278099E06F2956 CRC64;
     MPNLWFLLFL GLVAAMQLLL LLFLLLFFLV YWDHFECSCT GLPF