ID   VE6_BPV5                Reviewed;         134 AA.
AC   Q8BDG7;
DT   04-JAN-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   12-AUG-2020, entry version 67.
DE   RecName: Full=Protein E6 {ECO:0000255|HAMAP-Rule:MF_04006};
GN   Name=E6 {ECO:0000255|HAMAP-Rule:MF_04006};
OS   Bovine papillomavirus type 5.
OC   Viruses; Monodnaviria; Shotokuvirae; Cossaviricota; Papovaviricetes;
OC   Zurhausenvirales; Papillomaviridae; Firstpapillomavirinae;
OC   Epsilonpapillomavirus.
OX   NCBI_TaxID=40537;
OH   NCBI_TaxID=9913; Bos taurus (Bovine).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=12208979; DOI=10.1128/jvi.76.19.10020-10023.2002;
RA   Terai M., DeSalle R., Burk R.D.;
RT   "Lack of canonical E6 and E7 open reading frames in bird papillomaviruses:
RT   Fringilla coelebs papillomavirus and Psittacus erithacus timneh
RT   papillomavirus.";
RL   J. Virol. 76:10020-10023(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Delius H., de Villiers E.M.;
RT   "Sequencing of the complete genomes of BPV 3, BPV 5 and BPV 6.";
RL   Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays a major role in the induction and maintenance of
CC       cellular transformation. E6 associates with host UBE3A/E6-AP ubiquitin-
CC       protein ligase and modulates its activity. Protects host keratinocytes
CC       from apoptosis by mediating the degradation of host BAK1. May also
CC       inhibit host immune response. {ECO:0000255|HAMAP-Rule:MF_04006}.
CC   -!- SUBUNIT: Forms homodimers. Interacts with ubiquitin-protein ligase
CC       UBE3A/E6-AP; this interaction stimulates UBE3A ubiquitin activity.
CC       Interacts with host BAK1. {ECO:0000255|HAMAP-Rule:MF_04006}.
CC   -!- SUBCELLULAR LOCATION: Host cytoplasm {ECO:0000255|HAMAP-Rule:MF_04006}.
CC       Host nucleus {ECO:0000255|HAMAP-Rule:MF_04006}.
CC   -!- SIMILARITY: Belongs to the papillomaviridae E6 protein family.
CC       {ECO:0000255|HAMAP-Rule:MF_04006, ECO:0000305}.
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DR   EMBL; AF457465; AAN09924.1; -; Genomic_DNA.
DR   EMBL; AJ620206; CAF05671.1; -; Genomic_DNA.
DR   RefSeq; NP_694430.1; NC_004195.1.
DR   SMR; Q8BDG7; -.
DR   GeneID; 955402; -.
DR   KEGG; vg:955402; -.
DR   Proteomes; UP000008785; Genome.
DR   Proteomes; UP000185273; Genome.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0039526; P:modulation by virus of host apoptotic process; IEA:UniProtKB-KW.
DR   GO; GO:0039649; P:modulation by virus of host ubiquitin-protein ligase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   GO; GO:0039502; P:suppression by virus of host type I interferon-mediated signaling pathway; IEA:UniProtKB-UniRule.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.240.40; -; 2.
DR   HAMAP; MF_04006; HPV_E6; 1.
DR   InterPro; IPR001334; E6.
DR   InterPro; IPR038575; E6_sf.
DR   Pfam; PF00518; E6; 1.
DR   SUPFAM; SSF161229; SSF161229; 2.
PE   3: Inferred from homology;
KW   Activator; DNA-binding; Early protein; Host cytoplasm; Host nucleus;
KW   Host-virus interaction; Inhibition of host innate immune response by virus;
KW   Metal-binding; Modulation of host cell apoptosis by virus;
KW   Reference proteome; Transcription; Transcription regulation;
KW   Viral immunoevasion; Zinc; Zinc-finger.
FT   CHAIN           1..134
FT                   /note="Protein E6"
FT                   /id="PRO_0000133317"
FT   ZN_FING         15..51
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_04006"
FT   ZN_FING         88..124
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_04006"
SQ   SEQUENCE   134 AA;  15581 MW;  09775EC2384705BE CRC64;
     MPYWLPTYNF EGLQCLQCKK ALGSLDALKC KNHKYRRVHR GGKPYGMCQI CLEALLQLER
     QEFPWTLLLP KDFVKVLGRL PGDYCVRCYY CGCVLSDSEK DRHALDHEGY LYVRGRARGR
     CYSCSSDGRR PCVF