ID   VE6_HPV03               Reviewed;         152 AA.
AC   P36799; Q81960;
DT   01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1994, sequence version 1.
DT   07-APR-2021, entry version 85.
DE   RecName: Full=Protein E6 {ECO:0000255|HAMAP-Rule:MF_04006};
GN   Name=E6 {ECO:0000255|HAMAP-Rule:MF_04006};
OS   Human papillomavirus 3.
OC   Viruses; Monodnaviria; Shotokuvirae; Cossaviricota; Papovaviricetes;
OC   Zurhausenvirales; Papillomaviridae; Firstpapillomavirinae;
OC   Alphapapillomavirus.
OX   NCBI_TaxID=10614;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8205838; DOI=10.1007/978-3-642-78487-3_2;
RA   Delius H., Hofmann B.;
RT   "Primer-directed sequencing of human papillomavirus types.";
RL   Curr. Top. Microbiol. Immunol. 186:13-31(1994).
CC   -!- FUNCTION: Plays a major role in the induction and maintenance of
CC       cellular transformation. E6 associates with host UBE3A/E6-AP ubiquitin-
CC       protein ligase and modulates its activity. Sequesters tumor suppressor
CC       TP53 in the host cytoplasm and modulates its activity by interacting
CC       with host EP300 that results in the reduction of TP53 acetylation and
CC       activation. In turn, apoptosis induced by DNA damage is inhibited. E6
CC       protects also host keratinocytes from apoptosis by mediating the
CC       degradation of host BAK1. May also inhibit host immune response.
CC       {ECO:0000255|HAMAP-Rule:MF_04006}.
CC   -!- SUBUNIT: Forms homodimers. Interacts with ubiquitin-protein ligase
CC       UBE3A/E6-AP; this interaction stimulates UBE3A ubiquitin activity.
CC       Interacts with host TP53 and EP300; this interaction inhibits TP53
CC       activity. {ECO:0000255|HAMAP-Rule:MF_04006}.
CC   -!- INTERACTION:
CC       P36799; Q12959: DLG1; Xeno; NbExp=2; IntAct=EBI-7363822, EBI-357481;
CC       P36799; Q05086: UBE3A; Xeno; NbExp=2; IntAct=EBI-7363822, EBI-954357;
CC   -!- SUBCELLULAR LOCATION: Host cytoplasm {ECO:0000255|HAMAP-Rule:MF_04006}.
CC       Host nucleus {ECO:0000255|HAMAP-Rule:MF_04006}.
CC   -!- MISCELLANEOUS: Belongs to the low risk human alphapapillomavirus
CC       family. The cancer-causing human papillomavirus E6 protein has a unique
CC       carboxy terminal PDZ domain containing substrate but low risk E6s do
CC       not possess this domain. {ECO:0000255|HAMAP-Rule:MF_04006}.
CC   -!- SIMILARITY: Belongs to the papillomaviridae E6 protein family.
CC       {ECO:0000305}.
CC   -!- CAUTION: It is uncertain whether Met-1 or Met-5 is the initiator.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAA52470.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; X74462; CAA52469.1; -; Genomic_DNA.
DR   EMBL; X74462; CAA52470.1; ALT_INIT; Genomic_DNA.
DR   PIR; S36550; S36550.
DR   SMR; P36799; -.
DR   IntAct; P36799; 26.
DR   MINT; P36799; -.
DR   Proteomes; UP000007706; Genome.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0039526; P:modulation by virus of host apoptotic process; IEA:UniProtKB-KW.
DR   GO; GO:0039649; P:modulation by virus of host ubiquitin-protein ligase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   GO; GO:0039502; P:suppression by virus of host type I interferon-mediated signaling pathway; IEA:UniProtKB-UniRule.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.240.40; -; 2.
DR   HAMAP; MF_04006; HPV_E6; 1.
DR   InterPro; IPR001334; E6.
DR   InterPro; IPR038575; E6_sf.
DR   Pfam; PF00518; E6; 1.
DR   SUPFAM; SSF161229; SSF161229; 2.
PE   1: Evidence at protein level;
KW   Activator; DNA-binding; Early protein; Host cytoplasm; Host nucleus;
KW   Host-virus interaction; Inhibition of host innate immune response by virus;
KW   Metal-binding; Modulation of host cell apoptosis by virus; Transcription;
KW   Transcription regulation; Viral immunoevasion; Zinc; Zinc-finger.
FT   CHAIN           1..152
FT                   /note="Protein E6"
FT                   /id="PRO_0000133321"
FT   ZN_FING         33..69
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_04006"
FT   ZN_FING         106..142
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_04006"
SQ   SEQUENCE   152 AA;  17926 MW;  50E869412755862F CRC64;
     MAVAMSMDAN CPKNIFLLCR NTGIGFDDLR LHCIFCTKQL TTTELQAFAL RELNVVWRRG
     APYGACARCL LVEGIARRLK YWEYSYYVSG VEEETKQSID TQQIRCYMCH KPLVKEEKDR
     HRNEKRRLHK ISGHWRGSCQ YCWSRCTVRI PR