ID   VE6_HPV05               Reviewed;         157 AA.
AC   P06930;
DT   01-JAN-1988, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1996, sequence version 2.
DT   23-FEB-2022, entry version 98.
DE   RecName: Full=Protein E6 {ECO:0000255|HAMAP-Rule:MF_04006};
GN   Name=E6 {ECO:0000255|HAMAP-Rule:MF_04006};
OS   Human papillomavirus 5.
OC   Viruses; Monodnaviria; Shotokuvirae; Cossaviricota; Papovaviricetes;
OC   Zurhausenvirales; Papillomaviridae; Firstpapillomavirinae;
OC   Betapapillomavirus.
OX   NCBI_TaxID=333923;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=3033892; DOI=10.1016/0042-6822(87)90263-7;
RA   Zachow K.R., Ostrow R.S., Faras A.J.;
RT   "Nucleotide sequence and genome organization of human papillomavirus type
RT   5.";
RL   Virology 158:251-254(1987).
RN   [2]
RP   FUNCTION.
RX   PubMed=18715924; DOI=10.1128/jvi.00902-08;
RA   Underbrink M.P., Howie H.L., Bedard K.M., Koop J.I., Galloway D.A.;
RT   "E6 proteins from multiple human betapapillomavirus types degrade Bak and
RT   protect keratinocytes from apoptosis after UVB irradiation.";
RL   J. Virol. 82:10408-10417(2008).
RN   [3]
RP   FUNCTION, AND INTERACTION WITH HOST UBE3A/E6-AP.
RX   PubMed=18256157; DOI=10.1128/jvi.01818-07;
RA   Bedard K.M., Underbrink M.P., Howie H.L., Galloway D.A.;
RT   "The E6 oncoproteins from human betapapillomaviruses differentially
RT   activate telomerase through an E6AP-dependent mechanism and prolong the
RT   lifespan of primary keratinocytes.";
RL   J. Virol. 82:3894-3902(2008).
CC   -!- FUNCTION: Plays a major role in the induction and maintenance of
CC       cellular transformation. E6 associates with host UBE3A/E6-AP ubiquitin-
CC       protein ligase and modulates its activity. Protects host keratinocytes
CC       from apoptosis by mediating the degradation of host BAK1. May also
CC       inhibit host immune response. {ECO:0000255|HAMAP-Rule:MF_04006,
CC       ECO:0000269|PubMed:18256157, ECO:0000269|PubMed:18715924}.
CC   -!- SUBUNIT: Forms homodimers. Interacts with ubiquitin-protein ligase
CC       UBE3A/E6-AP; this interaction stimulates UBE3A ubiquitin activity.
CC       Interacts with host BAK1. {ECO:0000250|UniProtKB:P03126,
CC       ECO:0000255|HAMAP-Rule:MF_04006, ECO:0000269|PubMed:18256157}.
CC   -!- SUBCELLULAR LOCATION: Host cytoplasm {ECO:0000250|UniProtKB:P03126,
CC       ECO:0000255|HAMAP-Rule:MF_04006}. Host nucleus
CC       {ECO:0000250|UniProtKB:P03126, ECO:0000255|HAMAP-Rule:MF_04006}.
CC   -!- SIMILARITY: Belongs to the papillomaviridae E6 protein family.
CC       {ECO:0000255|HAMAP-Rule:MF_04006, ECO:0000305}.
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DR   EMBL; M17463; AAA46983.1; -; Genomic_DNA.
DR   PIR; F26277; W6WL5.
DR   RefSeq; NP_041365.1; NC_001531.1.
DR   SMR; P06930; -.
DR   BioGRID; 4263587; 53.
DR   IntAct; P06930; 52.
DR   MINT; P06930; -.
DR   PRIDE; P06930; -.
DR   GeneID; 1489047; -.
DR   KEGG; vg:1489047; -.
DR   Proteomes; UP000009252; Genome.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0039526; P:modulation by virus of host apoptotic process; IEA:UniProtKB-KW.
DR   GO; GO:0039649; P:modulation by virus of host ubiquitin-protein ligase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   GO; GO:0039502; P:suppression by virus of host type I interferon-mediated signaling pathway; IEA:UniProtKB-UniRule.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.240.40; -; 2.
DR   HAMAP; MF_04006; HPV_E6; 1.
DR   InterPro; IPR001334; E6.
DR   InterPro; IPR038575; E6_sf.
DR   Pfam; PF00518; E6; 1.
DR   SUPFAM; SSF161229; SSF161229; 2.
PE   1: Evidence at protein level;
KW   Activator; DNA-binding; Early protein; Host cytoplasm; Host nucleus;
KW   Host-virus interaction; Inhibition of host innate immune response by virus;
KW   Metal-binding; Modulation of host cell apoptosis by virus;
KW   Reference proteome; Transcription; Transcription regulation;
KW   Viral immunoevasion; Zinc; Zinc-finger.
FT   CHAIN           1..157
FT                   /note="Protein E6"
FT                   /id="PRO_0000133323"
FT   ZN_FING         41..77
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_04006"
FT   ZN_FING         114..150
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_04006"
SQ   SEQUENCE   157 AA;  18069 MW;  0FED9D328E263E75 CRC64;
     MAEGAEHQQK LTEKDKAELP LSIRDLAEAL GIPVIDCLIP CNFCGNFLNY LEACEFDYKR
     LSLIWKDYCV FACCRVCCGA TATYEFNQFY EQTVLGRDIE LASGLSIFDI DIRCQTCLAF
     LDIIEKLDCC GRGLPFHKVR NAWKGICRQC KHFYHDW