ID   VE6_HPV1                Reviewed;         140 AA.
AC   P06929;
DT   01-JAN-1988, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1988, sequence version 1.
DT   23-FEB-2022, entry version 99.
DE   RecName: Full=Protein E6 {ECO:0000255|HAMAP-Rule:MF_04006};
GN   Name=E6 {ECO:0000255|HAMAP-Rule:MF_04006};
OS   Human papillomavirus type 1 (Human papillomavirus type 1a).
OC   Viruses; Monodnaviria; Shotokuvirae; Cossaviricota; Papovaviricetes;
OC   Zurhausenvirales; Papillomaviridae; Firstpapillomavirinae;
OC   Mupapillomavirus.
OX   NCBI_TaxID=10583;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=6325156; DOI=10.1002/j.1460-2075.1982.tb01152.x;
RA   Danos O., Katinka M., Yaniv M.;
RT   "Human papillomavirus 1a complete DNA sequence: a novel type of genome
RT   organization among papovaviridae.";
RL   EMBO J. 1:231-236(1982).
RN   [2]
RP   SEQUENCE REVISION.
RA   Danos O.;
RL   Submitted (JAN-1985) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   COMPARATIVE ANALYSIS OF HUMAN TYPE 1A AND BOVINE TYPE 1 GENOMES.
RX   PubMed=6302319; DOI=10.1128/jvi.46.2.557-566.1983;
RA   Danos O., Engel L.W., Chen E.Y., Yaniv M., Howley P.M.;
RT   "Comparative analysis of the human type 1a and bovine type 1 papillomavirus
RT   genomes.";
RL   J. Virol. 46:557-566(1983).
CC   -!- FUNCTION: Plays a major role in the induction and maintenance of
CC       cellular transformation. E6 associates with host UBE3A/E6-AP ubiquitin-
CC       protein ligase and modulates its activity. Protects host keratinocytes
CC       from apoptosis by mediating the degradation of host BAK1. May also
CC       inhibit host immune response. {ECO:0000255|HAMAP-Rule:MF_04006}.
CC   -!- SUBUNIT: Forms homodimers. Interacts with ubiquitin-protein ligase
CC       UBE3A/E6-AP; this interaction stimulates UBE3A ubiquitin activity.
CC       Interacts with host BAK1. {ECO:0000255|HAMAP-Rule:MF_04006}.
CC   -!- SUBCELLULAR LOCATION: Host cytoplasm {ECO:0000255|HAMAP-Rule:MF_04006}.
CC       Host nucleus {ECO:0000255|HAMAP-Rule:MF_04006}.
CC   -!- SIMILARITY: Belongs to the papillomaviridae E6 protein family.
CC       {ECO:0000255|HAMAP-Rule:MF_04006, ECO:0000305}.
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DR   EMBL; V01116; CAA24314.1; -; Genomic_DNA.
DR   PIR; B17475; W6WL.
DR   RefSeq; NP_040305.1; NC_001356.1.
DR   SMR; P06929; -.
DR   IntAct; P06929; 53.
DR   MINT; P06929; -.
DR   PRIDE; P06929; -.
DR   GeneID; 1489169; -.
DR   KEGG; vg:1489169; -.
DR   Proteomes; UP000006372; Genome.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0039526; P:modulation by virus of host apoptotic process; IEA:UniProtKB-KW.
DR   GO; GO:0039649; P:modulation by virus of host ubiquitin-protein ligase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   GO; GO:0039502; P:suppression by virus of host type I interferon-mediated signaling pathway; IEA:UniProtKB-UniRule.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.240.40; -; 2.
DR   HAMAP; MF_04006; HPV_E6; 1.
DR   InterPro; IPR001334; E6.
DR   InterPro; IPR038575; E6_sf.
DR   Pfam; PF00518; E6; 1.
DR   SUPFAM; SSF161229; SSF161229; 2.
PE   3: Inferred from homology;
KW   Activator; DNA-binding; Early protein; Host cytoplasm; Host nucleus;
KW   Host-virus interaction; Inhibition of host innate immune response by virus;
KW   Metal-binding; Modulation of host cell apoptosis by virus;
KW   Reference proteome; Transcription; Transcription regulation;
KW   Viral immunoevasion; Zinc; Zinc-finger.
FT   CHAIN           1..140
FT                   /note="Protein E6"
FT                   /id="PRO_0000133319"
FT   ZN_FING         26..62
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_04006"
FT   ZN_FING         99..135
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_04006"
SQ   SEQUENCE   140 AA;  16317 MW;  31233D4074265157 CRC64;
     MATPIRTVRQ LSESLCIPYI DVLLPCNFCN YFLSNAEKLL FDHFDLHLVW RDNLVFGCCQ
     GCARTVSLLE FVLYYQESYE VPEIEEILDR PLLQIELRCV TCIKKLSVAE KLEVVSNGER
     VHRVRNRLKA KCSLCRLYAI