ID   VE6_HPV61               Reviewed;         146 AA.
AC   Q80948;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   02-DEC-2020, entry version 82.
DE   RecName: Full=Protein E6 {ECO:0000255|HAMAP-Rule:MF_04006};
GN   Name=E6 {ECO:0000255|HAMAP-Rule:MF_04006};
OS   Human papillomavirus type 61.
OC   Viruses; Monodnaviria; Shotokuvirae; Cossaviricota; Papovaviricetes;
OC   Zurhausenvirales; Papillomaviridae; Firstpapillomavirinae;
OC   Alphapapillomavirus.
OX   NCBI_TaxID=37116;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Delius H.;
RL   Submitted (OCT-1995) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays a major role in the induction and maintenance of
CC       cellular transformation. E6 associates with host UBE3A/E6-AP ubiquitin-
CC       protein ligase and modulates its activity. Sequesters tumor suppressor
CC       TP53 in the host cytoplasm and modulates its activity by interacting
CC       with host EP300 that results in the reduction of TP53 acetylation and
CC       activation. In turn, apoptosis induced by DNA damage is inhibited. E6
CC       protects also host keratinocytes from apoptosis by mediating the
CC       degradation of host BAK1. May also inhibit host immune response.
CC       {ECO:0000255|HAMAP-Rule:MF_04006}.
CC   -!- SUBUNIT: Forms homodimers. Interacts with ubiquitin-protein ligase
CC       UBE3A/E6-AP; this interaction stimulates UBE3A ubiquitin activity.
CC       Interacts with host TP53 and EP300; this interaction inhibits TP53
CC       activity. {ECO:0000255|HAMAP-Rule:MF_04006}.
CC   -!- SUBCELLULAR LOCATION: Host cytoplasm {ECO:0000255|HAMAP-Rule:MF_04006}.
CC       Host nucleus {ECO:0000255|HAMAP-Rule:MF_04006}.
CC   -!- MISCELLANEOUS: Belongs to the low risk human alphapapillomavirus
CC       family. The cancer-causing human papillomavirus E6 protein has a unique
CC       carboxy terminal PDZ domain containing substrate but low risk E6s do
CC       not possess this domain. {ECO:0000255|HAMAP-Rule:MF_04006}.
CC   -!- SIMILARITY: Belongs to the papillomaviridae E6 protein family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; U31793; AAA79492.1; -; Genomic_DNA.
DR   RefSeq; NP_043444.1; NC_001694.1.
DR   SMR; Q80948; -.
DR   GeneID; 1403312; -.
DR   KEGG; vg:1403312; -.
DR   Proteomes; UP000007670; Genome.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0039526; P:modulation by virus of host apoptotic process; IEA:UniProtKB-KW.
DR   GO; GO:0039649; P:modulation by virus of host ubiquitin-protein ligase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   GO; GO:0039502; P:suppression by virus of host type I interferon-mediated signaling pathway; IEA:UniProtKB-UniRule.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.240.40; -; 2.
DR   HAMAP; MF_04006; HPV_E6; 1.
DR   InterPro; IPR001334; E6.
DR   InterPro; IPR038575; E6_sf.
DR   Pfam; PF00518; E6; 1.
DR   SUPFAM; SSF161229; SSF161229; 2.
PE   3: Inferred from homology;
KW   Activator; DNA-binding; Early protein; Host cytoplasm; Host nucleus;
KW   Host-virus interaction; Inhibition of host innate immune response by virus;
KW   Metal-binding; Modulation of host cell apoptosis by virus;
KW   Reference proteome; Transcription; Transcription regulation;
KW   Viral immunoevasion; Zinc; Zinc-finger.
FT   CHAIN           1..146
FT                   /note="Protein E6"
FT                   /id="PRO_0000133377"
FT   ZN_FING         27..63
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_04006"
FT   ZN_FING         100..136
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_04006"
SQ   SEQUENCE   146 AA;  16992 MW;  D51EE3CC0D6670B1 CRC64;
     MGPCNPTNIF LLCKDYEVDF EDLRLTCVFC KNELTTEELL AFALKELSIV WRHNWPFGVC
     APCLAREVKV RELRHWDHSC YGPTVEQTTG RSLAELYIRC HACSKPLSIQ EKEHQVQAYI
     HFHYIAGQWT GRCCQCRGPC TARWQP