VE6_HPV6B
ID VE6_HPV6B Reviewed; 150 AA.
AC P06462;
DT 01-JAN-1988, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1988, sequence version 1.
DT 02-JUN-2021, entry version 108.
DE RecName: Full=Protein E6 {ECO:0000255|HAMAP-Rule:MF_04006};
GN Name=E6 {ECO:0000255|HAMAP-Rule:MF_04006};
OS Human papillomavirus type 6b.
OC Viruses; Monodnaviria; Shotokuvirae; Cossaviricota; Papovaviricetes;
OC Zurhausenvirales; Papillomaviridae; Firstpapillomavirinae;
OC Alphapapillomavirus.
OX NCBI_TaxID=10600;
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=6321162; DOI=10.1002/j.1460-2075.1983.tb01744.x;
RA Schwarz E., Durst M., Demankowski C., Lattermann O., Zech R.,
RA Wolfsperger E., Suhai S., zur Hausen H.;
RT "DNA sequence and genome organization of genital human papillomavirus type
RT 6b.";
RL EMBO J. 2:2341-2348(1983).
RN [2]
RP INTERACTION WITH ZYXIN.
RX PubMed=11689660; DOI=10.1128/jvi.75.23.11791-11802.2001;
RA Degenhardt Y.Y., Silverstein S.;
RT "Interaction of zyxin, a focal adhesion protein, with the E6 protein from
RT human papillomavirus type 6 results in its nuclear translocation.";
RL J. Virol. 75:11791-11802(2001).
CC -!- FUNCTION: Plays a major role in the induction and maintenance of
CC cellular transformation. E6 associates with host UBE3A/E6-AP ubiquitin-
CC protein ligase and modulates its activity. Sequesters tumor suppressor
CC TP53 in the host cytoplasm and modulates its activity by interacting
CC with host EP300 that results in the reduction of TP53 acetylation and
CC activation. In turn, apoptosis induced by DNA damage is inhibited. E6
CC protects also host keratinocytes from apoptosis by mediating the
CC degradation of host BAK1. May also inhibit host immune response.
CC {ECO:0000255|HAMAP-Rule:MF_04006}.
CC -!- SUBUNIT: Forms homodimers. Interacts with ubiquitin-protein ligase
CC UBE3A/E6-AP; this interaction stimulates UBE3A ubiquitin activity.
CC Interacts with host TP53 and EP300; this interaction inhibits TP53
CC activity. Interacts with human zyxin. {ECO:0000255|HAMAP-Rule:MF_04006,
CC ECO:0000269|PubMed:11689660}.
CC -!- INTERACTION:
CC P06462; P33993: MCM7; Xeno; NbExp=2; IntAct=EBI-7069993, EBI-355924;
CC P06462; Q05086: UBE3A; Xeno; NbExp=2; IntAct=EBI-7069993, EBI-954357;
CC -!- SUBCELLULAR LOCATION: Host cytoplasm {ECO:0000255|HAMAP-Rule:MF_04006}.
CC Host nucleus {ECO:0000255|HAMAP-Rule:MF_04006}.
CC -!- MISCELLANEOUS: Belongs to the low risk human alphapapillomavirus
CC family. The cancer-causing human papillomavirus E6 protein has a unique
CC carboxy terminal PDZ domain containing substrate but low risk E6s do
CC not possess this domain. {ECO:0000255|HAMAP-Rule:MF_04006}.
CC -!- SIMILARITY: Belongs to the papillomaviridae E6 protein family.
CC {ECO:0000305}.
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DR EMBL; X00203; CAA25018.1; -; Genomic_DNA.
DR PIR; E20558; W6WL6.
DR RefSeq; NP_040296.1; NC_001355.1.
DR SMR; P06462; -.
DR BioGRID; 3509162; 27.
DR IntAct; P06462; 7.
DR MINT; P06462; -.
DR PRIDE; P06462; -.
DR DNASU; 1489368; -.
DR GeneID; 1489368; -.
DR KEGG; vg:1489368; -.
DR Proteomes; UP000007676; Genome.
DR GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0039526; P:modulation by virus of host apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:0039649; P:modulation by virus of host ubiquitin-protein ligase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR GO; GO:0039502; P:suppression by virus of host type I interferon-mediated signaling pathway; IEA:UniProtKB-UniRule.
DR GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.240.40; -; 2.
DR HAMAP; MF_04006; HPV_E6; 1.
DR InterPro; IPR001334; E6.
DR InterPro; IPR038575; E6_sf.
DR Pfam; PF00518; E6; 1.
DR SUPFAM; SSF161229; SSF161229; 2.
PE 1: Evidence at protein level;
KW Activator; DNA-binding; Early protein; Host cytoplasm; Host nucleus;
KW Host-virus interaction; Inhibition of host innate immune response by virus;
KW Metal-binding; Modulation of host cell apoptosis by virus; Transcription;
KW Transcription regulation; Viral immunoevasion; Zinc; Zinc-finger.
FT CHAIN 1..150
FT /note="Protein E6"
FT /id="PRO_0000133326"
FT ZN_FING 31..67
FT /evidence="ECO:0000255|HAMAP-Rule:MF_04006"
FT ZN_FING 104..140
FT /evidence="ECO:0000255|HAMAP-Rule:MF_04006"
SQ SEQUENCE 150 AA; 17299 MW; F7C5EF80356A4DF9 CRC64;
MESANASTSA TTIDQLCKTF NLSMHTLQIN CVFCKNALTT AEIYSYAYKH LKVLFRGGYP
YAACACCLEF HGKINQYRHF DYAGYATTVE EETKQDILDV LIRCYLCHKP LCEVEKVKHI
LTKARFIKLN CTWKGRCLHC WTTCMEDMLP
