VE6_MMPV
ID VE6_MMPV Reviewed; 153 AA.
AC P30734;
DT 01-APR-1993, integrated into UniProtKB/Swiss-Prot.
DT 01-APR-1993, sequence version 1.
DT 12-AUG-2020, entry version 77.
DE RecName: Full=Protein E6 {ECO:0000255|HAMAP-Rule:MF_04006};
GN Name=E6 {ECO:0000255|HAMAP-Rule:MF_04006};
OS Micromys minutus papillomavirus (MmPV) (Old world harvest mouse
OS papillomavirus).
OC Viruses; Monodnaviria; Shotokuvirae; Cossaviricota; Papovaviricetes;
OC Zurhausenvirales; Papillomaviridae; Firstpapillomavirinae;
OC Pipapillomavirus.
OX NCBI_TaxID=10568;
OH NCBI_TaxID=13151; Micromys minutus (European harvest mouse).
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=1319576; DOI=10.1093/nar/20.11.2889;
RA van Ranst M., Tachezy R., Pruss J., Burk R.;
RT "Primary structure of the E6 protein of Micromys minutus papillomavirus and
RT Mastomys natalensis papillomavirus.";
RL Nucleic Acids Res. 20:2889-2889(1992).
CC -!- FUNCTION: Plays a major role in the induction and maintenance of
CC cellular transformation. E6 associates with host UBE3A/E6-AP ubiquitin-
CC protein ligase and modulates its activity. Protects host keratinocytes
CC from apoptosis by mediating the degradation of host BAK1. May also
CC inhibit host immune response. {ECO:0000255|HAMAP-Rule:MF_04006}.
CC -!- SUBUNIT: Forms homodimers. Interacts with ubiquitin-protein ligase
CC UBE3A/E6-AP; this interaction stimulates UBE3A ubiquitin activity.
CC Interacts with host BAK1. {ECO:0000255|HAMAP-Rule:MF_04006}.
CC -!- SUBCELLULAR LOCATION: Host cytoplasm {ECO:0000255|HAMAP-Rule:MF_04006}.
CC Host nucleus {ECO:0000255|HAMAP-Rule:MF_04006}.
CC -!- SIMILARITY: Belongs to the papillomaviridae E6 protein family.
CC {ECO:0000255|HAMAP-Rule:MF_04006, ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAA46319.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; X65200; CAA46319.1; ALT_INIT; Genomic_DNA.
DR PIR; S28509; S28509.
DR RefSeq; YP_873939.1; NC_008582.1.
DR SMR; P30734; -.
DR GeneID; 5075640; -.
DR KEGG; vg:5075640; -.
DR GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0039526; P:modulation by virus of host apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:0039649; P:modulation by virus of host ubiquitin-protein ligase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR GO; GO:0039502; P:suppression by virus of host type I interferon-mediated signaling pathway; IEA:UniProtKB-UniRule.
DR GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.240.40; -; 2.
DR HAMAP; MF_04006; HPV_E6; 1.
DR InterPro; IPR001334; E6.
DR InterPro; IPR038575; E6_sf.
DR Pfam; PF00518; E6; 1.
DR SUPFAM; SSF161229; SSF161229; 2.
PE 3: Inferred from homology;
KW Activator; DNA-binding; Early protein; Host cytoplasm; Host nucleus;
KW Host-virus interaction; Inhibition of host innate immune response by virus;
KW Metal-binding; Modulation of host cell apoptosis by virus; Transcription;
KW Transcription regulation; Viral immunoevasion; Zinc; Zinc-finger.
FT CHAIN 1..153
FT /note="Protein E6"
FT /id="PRO_0000133387"
FT ZN_FING 37..73
FT /evidence="ECO:0000255|HAMAP-Rule:MF_04006"
FT ZN_FING 110..146
FT /evidence="ECO:0000255|HAMAP-Rule:MF_04006"
SQ SEQUENCE 153 AA; 17489 MW; 3BDFDC02C91219D5 CRC64;
MPQPTRPYSF MELCREYTLE QLLKFLNVTL DTLMLPCHFC SSFMDLNNKA SYLASQLKVI
VKDCCFKGAC IKCRRKLAFA ERQKYQVCVG EADLVEAMVG SHVINLTVRC SECLALLTAS
EKLDAKCELQ TFILVRHMWR TSCRACRTPA IEC
