ID   VE6_MNPVA               Reviewed;         135 AA.
AC   P30735; Q84354;
DT   01-APR-1993, integrated into UniProtKB/Swiss-Prot.
DT   14-DEC-2011, sequence version 2.
DT   02-DEC-2020, entry version 82.
DE   RecName: Full=Protein E6 {ECO:0000255|HAMAP-Rule:MF_04006};
GN   Name=E6 {ECO:0000255|HAMAP-Rule:MF_04006};
OS   Mastomys natalensis papillomavirus (isolate African multimammate rat)
OS   (MnPV).
OC   Viruses; Monodnaviria; Shotokuvirae; Cossaviricota; Papovaviricetes;
OC   Zurhausenvirales; Papillomaviridae; Firstpapillomavirinae;
OC   Iotapapillomavirus.
OX   NCBI_TaxID=654915;
OH   NCBI_TaxID=10112; Mastomys natalensis (African soft-furred rat) (Praomys natalensis).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=1319576; DOI=10.1093/nar/20.11.2889;
RA   van Ranst M., Tachezy R., Pruss J., Burk R.;
RT   "Primary structure of the E6 protein of Micromys minutus papillomavirus and
RT   Mastomys natalensis papillomavirus.";
RL   Nucleic Acids Res. 20:2889-2889(1992).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8291235; DOI=10.1006/viro.1994.1064;
RA   Tan C.-H., Tachezy R., van Ranst M., Chan S.-Y., Bernard H.-U., Burk R.D.;
RT   "The Mastomys natalensis papillomavirus: nucleotide sequence, genome
RT   organization, and phylogenetic relationship of a rodent papillomavirus
RT   involved in tumorigenesis of cutaneous epithelia.";
RL   Virology 198:534-541(1994).
CC   -!- FUNCTION: Plays a major role in the induction and maintenance of
CC       cellular transformation. E6 associates with host UBE3A/E6-AP ubiquitin-
CC       protein ligase and modulates its activity. Protects host keratinocytes
CC       from apoptosis by mediating the degradation of host BAK1. May also
CC       inhibit host immune response. {ECO:0000255|HAMAP-Rule:MF_04006}.
CC   -!- SUBUNIT: Forms homodimers. Interacts with ubiquitin-protein ligase
CC       UBE3A/E6-AP; this interaction stimulates UBE3A ubiquitin activity.
CC       Interacts with host BAK1. {ECO:0000255|HAMAP-Rule:MF_04006}.
CC   -!- SUBCELLULAR LOCATION: Host cytoplasm {ECO:0000255|HAMAP-Rule:MF_04006}.
CC       Host nucleus {ECO:0000255|HAMAP-Rule:MF_04006}.
CC   -!- SIMILARITY: Belongs to the papillomaviridae E6 protein family.
CC       {ECO:0000255|HAMAP-Rule:MF_04006, ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAA46320.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; X65201; CAA46320.1; ALT_INIT; Genomic_DNA.
DR   EMBL; U01834; AAA67144.1; -; Genomic_DNA.
DR   PIR; S28510; S28510.
DR   RefSeq; NP_042014.1; NC_001605.1.
DR   SMR; P30735; -.
DR   GeneID; 1488998; -.
DR   KEGG; vg:1488998; -.
DR   Proteomes; UP000007018; Genome.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0039526; P:modulation by virus of host apoptotic process; IEA:UniProtKB-KW.
DR   GO; GO:0039649; P:modulation by virus of host ubiquitin-protein ligase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   GO; GO:0039502; P:suppression by virus of host type I interferon-mediated signaling pathway; IEA:UniProtKB-UniRule.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.240.40; -; 2.
DR   HAMAP; MF_04006; HPV_E6; 1.
DR   InterPro; IPR001334; E6.
DR   InterPro; IPR038575; E6_sf.
DR   Pfam; PF00518; E6; 1.
DR   SUPFAM; SSF161229; SSF161229; 2.
PE   3: Inferred from homology;
KW   Activator; DNA-binding; Early protein; Host cytoplasm; Host nucleus;
KW   Host-virus interaction; Inhibition of host innate immune response by virus;
KW   Metal-binding; Modulation of host cell apoptosis by virus;
KW   Reference proteome; Transcription; Transcription regulation;
KW   Viral immunoevasion; Zinc; Zinc-finger.
FT   CHAIN           1..135
FT                   /note="Protein E6"
FT                   /id="PRO_0000133388"
FT   ZN_FING         23..59
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_04006"
FT   ZN_FING         96..132
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_04006"
SQ   SEQUENCE   135 AA;  15468 MW;  1119159D43B6D5E4 CRC64;
     MDRTVHSFVE RLGIPREDLL LPCTFCSRFL TQEELTAFDF SAFNLVWRGR CAHGICTACA
     RVCASLDLFL HHQNSRPLAD VLRDENLTLH GLKARCRVCM KILSVTEKLE CAERGESFAK
     VRGQWRARCR ICKPV