VE7_HPV05
ID VE7_HPV05 Reviewed; 103 AA.
AC P06932; Q6LBH5; Q6YNY3; Q81963; Q81987;
DT 01-JAN-1988, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1988, sequence version 1.
DT 03-AUG-2022, entry version 104.
DE RecName: Full=Protein E7 {ECO:0000255|HAMAP-Rule:MF_04004};
GN Name=E7 {ECO:0000255|HAMAP-Rule:MF_04004};
OS Human papillomavirus 5.
OC Viruses; Monodnaviria; Shotokuvirae; Cossaviricota; Papovaviricetes;
OC Zurhausenvirales; Papillomaviridae; Firstpapillomavirinae;
OC Betapapillomavirus.
OX NCBI_TaxID=333923;
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=3033892; DOI=10.1016/0042-6822(87)90263-7;
RA Zachow K.R., Ostrow R.S., Faras A.J.;
RT "Nucleotide sequence and genome organization of human papillomavirus type
RT 5.";
RL Virology 158:251-254(1987).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Isolate 5a2, Isolate 5a4, Isolate 5a5, and Isolate 5a6;
RX PubMed=8263176; DOI=10.1128/jcm.31.11.2918-2926.1993;
RA Deau M.C., Favre M., Jablonska S., Rueda L.A., Orth G.;
RT "Genetic heterogeneity of oncogenic human papillomavirus type 5 (HPV5) and
RT phylogeny of HPV5 variants associated with epidermodysplasia
RT verruciformis.";
RL J. Clin. Microbiol. 31:2918-2926(1993).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Isolate P5-16;
RA Mahe E., Orth G., Favre M.;
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP REVIEW.
RX PubMed=11921304; DOI=10.1002/rmv.340;
RA Lee C., Cho Y.;
RT "Interactions of SV40 large T antigen and other viral proteins with
RT retinoblastoma tumour suppressor.";
RL Rev. Med. Virol. 12:81-92(2002).
CC -!- FUNCTION: Plays a role in viral genome replication by driving entry of
CC quiescent cells into the cell cycle. Stimulation of progression from G1
CC to S phase allows the virus to efficiently use the cellular DNA
CC replicating machinery to achieve viral genome replication. E7 protein
CC has both transforming and trans-activating activities. Induces the
CC disassembly of the E2F1 transcription factor from RB1, with subsequent
CC transcriptional activation of E2F1-regulated S-phase genes. Interferes
CC with host histone deacetylation mediated by HDAC1 and HDAC2, leading to
CC transcription activation. Also plays a role in the inhibition of both
CC antiviral and antiproliferative functions of host interferon alpha.
CC Interaction with host TMEM173/STING impairs the ability of
CC TMEM173/STING to sense cytosolic DNA and promote the production of type
CC I interferon (IFN-alpha and IFN-beta). {ECO:0000255|HAMAP-
CC Rule:MF_04004}.
CC -!- SUBUNIT: Homodimer. Homooligomer. Interacts with host RB1; this
CC interaction induces dissociation of RB1-E2F1 complex thereby disrupting
CC RB1 activity. Interacts with host EP300; this interaction represses
CC EP300 transcriptional activity. Interacts with protein E2; this
CC interaction inhibits E7 oncogenic activity. Interacts with host
CC TMEM173/STING; this interaction impairs the ability of TMEM173/STING to
CC sense cytosolic DNA and promote the production of type I interferon
CC (IFN-alpha and IFN-beta). {ECO:0000255|HAMAP-Rule:MF_04004}.
CC -!- SUBCELLULAR LOCATION: Host cytoplasm {ECO:0000255|HAMAP-Rule:MF_04004}.
CC Host nucleus {ECO:0000255|HAMAP-Rule:MF_04004}. Note=Predominantly
CC found in the host nucleus. {ECO:0000255|HAMAP-Rule:MF_04004}.
CC -!- DOMAIN: The E7 terminal domain is an intrinsically disordered domain,
CC whose flexibility and conformational transitions confer target
CC adaptability to the oncoprotein. It allows adaptation to a variety of
CC protein targets and exposes the PEST degradation sequence that
CC regulates its turnover in the cell. {ECO:0000255|HAMAP-Rule:MF_04004}.
CC -!- PTM: Highly phosphorylated. {ECO:0000255|HAMAP-Rule:MF_04004}.
CC -!- SIMILARITY: Belongs to the papillomaviridae E7 protein family.
CC {ECO:0000255|HAMAP-Rule:MF_04004}.
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DR EMBL; M17463; AAA46984.1; -; Genomic_DNA.
DR EMBL; X74618; CAA52690.1; -; Genomic_DNA.
DR EMBL; X74619; CAA52692.1; -; Genomic_DNA.
DR EMBL; X74620; CAA52694.1; -; Genomic_DNA.
DR EMBL; X74621; CAA52696.1; -; Genomic_DNA.
DR EMBL; X74622; CAA52698.1; -; Genomic_DNA.
DR EMBL; AY044308; AAK95795.1; -; Genomic_DNA.
DR PIR; G26277; W7WL5.
DR RefSeq; NP_041366.1; NC_001531.1.
DR SMR; P06932; -.
DR BioGRID; 4263588; 79.
DR IntAct; P06932; 59.
DR MINT; P06932; -.
DR PRIDE; P06932; -.
DR GeneID; 1489048; -.
DR KEGG; vg:1489048; -.
DR Proteomes; UP000009252; Genome.
DR GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0019904; F:protein domain specific binding; IEA:UniProtKB-UniRule.
DR GO; GO:0039645; P:modulation by virus of host G1/S transition checkpoint; IEA:UniProtKB-UniRule.
DR GO; GO:0039502; P:suppression by virus of host type I interferon-mediated signaling pathway; IEA:UniProtKB-UniRule.
DR GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR HAMAP; MF_04004; PPV_E7; 1.
DR InterPro; IPR000148; Papilloma_E7.
DR Pfam; PF00527; E7; 1.
DR PIRSF; PIRSF003407; Papvi_E7; 1.
PE 3: Inferred from homology;
KW Activator; DNA-binding; Early protein;
KW G1/S host cell cycle checkpoint dysregulation by virus; Host cytoplasm;
KW Host nucleus; Host-virus interaction;
KW Inhibition of host innate immune response by virus;
KW Inhibition of host interferon signaling pathway by virus; Metal-binding;
KW Modulation of host cell cycle by virus; Oncogene; Reference proteome;
KW Transcription; Transcription regulation; Viral immunoevasion; Zinc;
KW Zinc-finger.
FT CHAIN 1..103
FT /note="Protein E7"
FT /id="PRO_0000133402"
FT ZN_FING 56..94
FT /evidence="ECO:0000255|HAMAP-Rule:MF_04004"
FT REGION 1..48
FT /note="E7 terminal domain"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_04004"
FT MOTIF 27..31
FT /note="LXCXE motif; interaction with host RB1 and
FT TMEM173/STING"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_04004"
FT MOTIF 76..84
FT /note="Nuclear export signal"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_04004"
FT VARIANT 28
FT /note="F -> Y (in strain: Isolate 5a6)"
FT VARIANT 45
FT /note="N -> I (in strain: Isolate 5a4 and Isolate 5a6)"
FT VARIANT 49
FT /note="S -> F (in strain: Isolate 5a5)"
FT VARIANT 60
FT /note="N -> H (in strain: Isolate 5a4 and Isolate 5a6)"
SQ SEQUENCE 103 AA; 11677 MW; A9FF74AD5C7EBBED CRC64;
MIGKEVTVQD IILELSEVQP EVLPVDLFCE EELPNEQETE EEPDNERISY KVIAPCGCRN
CEVKLRIFVH ATEFGIRAFQ QLLTGDLQLL CPDCRGNCKH DGS
