VE7_HPV11
ID VE7_HPV11 Reviewed; 98 AA.
AC P04020;
DT 23-OCT-1986, integrated into UniProtKB/Swiss-Prot.
DT 23-OCT-1986, sequence version 1.
DT 03-AUG-2022, entry version 111.
DE RecName: Full=Protein E7 {ECO:0000255|HAMAP-Rule:MF_04004};
GN Name=E7 {ECO:0000255|HAMAP-Rule:MF_04004};
OS Human papillomavirus 11.
OC Viruses; Monodnaviria; Shotokuvirae; Cossaviricota; Papovaviricetes;
OC Zurhausenvirales; Papillomaviridae; Firstpapillomavirinae;
OC Alphapapillomavirus.
OX NCBI_TaxID=10580;
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=3008427; DOI=10.1016/0042-6822(86)90110-8;
RA Dartmann K., Schwarz E., Gissmann L., zur Hausen H.;
RT "The nucleotide sequence and genome organization of human papilloma virus
RT type 11.";
RL Virology 151:124-130(1986).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=8956761; DOI=10.1001/archotol.1996.01890240110025;
RA Fife K.H., Fan L., Fritsch M.H., Bryan J., Brown D.R.;
RT "Association of human papillomavirus type 11 DNA with squamous cell
RT carcinoma of the tongue.";
RL Arch. Otolaryngol. Head Neck Surg. 122:1404-1408(1996).
RN [3]
RP INTERACTION WITH HUMAN ZUBR1.
RX PubMed=16061792; DOI=10.1073/pnas.0505337102;
RA Huh K.-W., DeMasi J., Ogawa H., Nakatani Y., Howley P.M., Muenger K.;
RT "Association of the human papillomavirus type 16 E7 oncoprotein with the
RT 600-kDa retinoblastoma protein-associated factor, p600.";
RL Proc. Natl. Acad. Sci. U.S.A. 102:11492-11497(2005).
RN [4]
RP REVIEW.
RX PubMed=11921304; DOI=10.1002/rmv.340;
RA Lee C., Cho Y.;
RT "Interactions of SV40 large T antigen and other viral proteins with
RT retinoblastoma tumour suppressor.";
RL Rev. Med. Virol. 12:81-92(2002).
CC -!- FUNCTION: Plays a role in viral genome replication by driving entry of
CC quiescent cells into the cell cycle. Stimulation of progression from G1
CC to S phase allows the virus to efficiently use the cellular DNA
CC replicating machinery to achieve viral genome replication. E7 protein
CC has both transforming and trans-activating activities. Induces the
CC disassembly of the E2F1 transcription factor from RB1, with subsequent
CC transcriptional activation of E2F1-regulated S-phase genes. Interferes
CC with host histone deacetylation mediated by HDAC1 and HDAC2, leading to
CC transcription activation. Also plays a role in the inhibition of both
CC antiviral and antiproliferative functions of host interferon alpha.
CC Interaction with host TMEM173/STING impairs the ability of
CC TMEM173/STING to sense cytosolic DNA and promote the production of type
CC I interferon (IFN-alpha and IFN-beta). {ECO:0000255|HAMAP-
CC Rule:MF_04004}.
CC -!- SUBUNIT: Homodimer. Homooligomer. Interacts with host RB1; this
CC interaction induces dissociation of RB1-E2F1 complex thereby disrupting
CC RB1 activity. Interacts with host EP300; this interaction represses
CC EP300 transcriptional activity. Interacts with protein E2; this
CC interaction inhibits E7 oncogenic activity. Interacts with host
CC TMEM173/STING; this interaction impairs the ability of TMEM173/STING to
CC sense cytosolic DNA and promote the production of type I interferon
CC (IFN-alpha and IFN-beta). Interacts with host ZUBR1.
CC {ECO:0000255|HAMAP-Rule:MF_04004, ECO:0000269|PubMed:16061792}.
CC -!- INTERACTION:
CC P04020; P01106: MYC; Xeno; NbExp=2; IntAct=EBI-7005254, EBI-447544;
CC P04020; P67775: PPP2CA; Xeno; NbExp=2; IntAct=EBI-7005254, EBI-712311;
CC P04020; P30153: PPP2R1A; Xeno; NbExp=2; IntAct=EBI-7005254, EBI-302388;
CC P04020; P06400: RB1; Xeno; NbExp=3; IntAct=EBI-7005254, EBI-491274;
CC P04020; Q5T4S7: UBR4; Xeno; NbExp=2; IntAct=EBI-7005254, EBI-1995940;
CC -!- SUBCELLULAR LOCATION: Host cytoplasm {ECO:0000255|HAMAP-Rule:MF_04004}.
CC Host nucleus {ECO:0000255|HAMAP-Rule:MF_04004}. Note=Predominantly
CC found in the host nucleus. {ECO:0000255|HAMAP-Rule:MF_04004}.
CC -!- DOMAIN: The E7 terminal domain is an intrinsically disordered domain,
CC whose flexibility and conformational transitions confer target
CC adaptability to the oncoprotein. It allows adaptation to a variety of
CC protein targets and exposes the PEST degradation sequence that
CC regulates its turnover in the cell. {ECO:0000255|HAMAP-Rule:MF_04004}.
CC -!- PTM: Highly phosphorylated. {ECO:0000255|HAMAP-Rule:MF_04004}.
CC -!- SIMILARITY: Belongs to the papillomaviridae E7 protein family.
CC {ECO:0000255|HAMAP-Rule:MF_04004}.
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DR EMBL; M14119; AAA46928.1; -; Genomic_DNA.
DR EMBL; L36108; AAA21704.1; -; Genomic_DNA.
DR PIR; A03690; W7WL11.
DR SMR; P04020; -.
DR IntAct; P04020; 43.
DR MINT; P04020; -.
DR Proteomes; UP000008222; Genome.
DR GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0019904; F:protein domain specific binding; IEA:UniProtKB-UniRule.
DR GO; GO:0039645; P:modulation by virus of host G1/S transition checkpoint; IEA:UniProtKB-UniRule.
DR GO; GO:0039502; P:suppression by virus of host type I interferon-mediated signaling pathway; IEA:UniProtKB-UniRule.
DR GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR HAMAP; MF_04004; PPV_E7; 1.
DR InterPro; IPR000148; Papilloma_E7.
DR Pfam; PF00527; E7; 1.
DR PIRSF; PIRSF003407; Papvi_E7; 1.
PE 1: Evidence at protein level;
KW Activator; DNA-binding; Early protein;
KW G1/S host cell cycle checkpoint dysregulation by virus; Host cytoplasm;
KW Host nucleus; Host-virus interaction;
KW Inhibition of host innate immune response by virus;
KW Inhibition of host interferon signaling pathway by virus; Metal-binding;
KW Modulation of host cell cycle by virus; Oncogene; Reference proteome;
KW Transcription; Transcription regulation; Viral immunoevasion; Zinc;
KW Zinc-finger.
FT CHAIN 1..98
FT /note="Protein E7"
FT /id="PRO_0000133410"
FT ZN_FING 58..94
FT /evidence="ECO:0000255|HAMAP-Rule:MF_04004"
FT REGION 1..42
FT /note="E7 terminal domain"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_04004"
FT MOTIF 23..27
FT /note="LXCXE motif; interaction with host RB1 and
FT TMEM173/STING"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_04004"
FT MOTIF 76..84
FT /note="Nuclear export signal"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_04004"
SQ SEQUENCE 98 AA; 10889 MW; AACA9A60C933E1F6 CRC64;
MHGRLVTLKD IVLDLQPPDP VGLHCYEQLE DSSEDEVDKV DKQDAQPLTQ HYQILTCCCG
CDSNVRLVVE CTDGDIRQLQ DLLLGTLNIV CPICAPKP
