ID   VE8E2_BPV5              Reviewed;         225 AA.
AC   P0DOD8;
DT   18-JAN-2017, integrated into UniProtKB/Swiss-Prot.
DT   18-JAN-2017, sequence version 1.
DT   02-JUN-2021, entry version 17.
DE   RecName: Full=Protein E8^E2C;
OS   Bovine papillomavirus type 5.
OC   Viruses; Monodnaviria; Shotokuvirae; Cossaviricota; Papovaviricetes;
OC   Zurhausenvirales; Papillomaviridae; Firstpapillomavirinae;
OC   Epsilonpapillomavirus.
OX   NCBI_TaxID=40537;
OH   NCBI_TaxID=9913; Bos taurus (Bovine).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=12208979; DOI=10.1128/jvi.76.19.10020-10023.2002;
RA   Terai M., DeSalle R., Burk R.D.;
RT   "Lack of canonical E6 and E7 open reading frames in bird papillomaviruses:
RT   Fringilla coelebs papillomavirus and Psittacus erithacus timneh
RT   papillomavirus.";
RL   J. Virol. 76:10020-10023(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Delius H., de Villiers E.M.;
RT   "Sequencing of the complete genomes of BPV 3, BPV 5 and BPV 6.";
RL   Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays a role in limiting the replication of viral DNA in
CC       keratinocytes. Recruits the host NCoR/SMRT complex to viral replication
CC       foci to mediate repression of both viral replication and transcription.
CC       {ECO:0000250|UniProtKB:P0DKA0}.
CC   -!- SUBCELLULAR LOCATION: Host nucleus {ECO:0000250|UniProtKB:P0DKA0}.
CC   -!- SIMILARITY: Belongs to the papillomaviridae E8^E2C protein family.
CC       {ECO:0000305}.
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DR   EMBL; AF457465; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AJ620206; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   SMR; P0DOD8; -.
DR   Proteomes; UP000008785; Genome.
DR   Proteomes; UP000185273; Genome.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:InterPro.
DR   Gene3D; 3.30.70.330; -; 1.
DR   InterPro; IPR035975; E2/EBNA1_C_sf.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR000427; Papillomavirus_E2_C.
DR   Pfam; PF00511; PPV_E2_C; 1.
DR   SUPFAM; SSF54957; SSF54957; 1.
PE   3: Inferred from homology;
KW   Host nucleus; Reference proteome.
FT   CHAIN           1..225
FT                   /note="Protein E8^E2C"
FT                   /id="PRO_0000438763"
FT   REGION          1..67
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          85..128
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        85..111
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        112..128
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   225 AA;  24376 MW;  401E52C43EC21FE8 CRC64;
     MKLVMLLRPP PQTHRADTTD GLPGLQEEPR GGDGPTCSGP APAIPDSPSR CLSRGFAGRD
     PGCHRNRHRV HPYILSGGQR ILVTSSSSST VQGPLSSGSS QHSQSRGRPP SPDSTETERA
     RTPVNSDRQR AGEFDLLKGG CRPCCLIEGN GNKVKCLRFR LKKSHRSRFL DITTTFWATG
     DEGSDRQGNG TILITFTDTT QRDLFLGSVS IPGELSVRRI TISTD