ID   VE8E2_HPV05             Reviewed;         323 AA.
AC   P0DOD3;
DT   18-JAN-2017, integrated into UniProtKB/Swiss-Prot.
DT   18-JAN-2017, sequence version 1.
DT   02-JUN-2021, entry version 17.
DE   RecName: Full=Protein E8^E2C;
OS   Human papillomavirus 5.
OC   Viruses; Monodnaviria; Shotokuvirae; Cossaviricota; Papovaviricetes;
OC   Zurhausenvirales; Papillomaviridae; Firstpapillomavirinae;
OC   Betapapillomavirus.
OX   NCBI_TaxID=333923;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=3033892; DOI=10.1016/0042-6822(87)90263-7;
RA   Zachow K.R., Ostrow R.S., Faras A.J.;
RT   "Nucleotide sequence and genome organization of human papillomavirus type
RT   5.";
RL   Virology 158:251-254(1987).
CC   -!- FUNCTION: Plays a role in limiting the replication of viral DNA in
CC       keratinocytes. Recruits the host NCoR/SMRT complex to viral replication
CC       foci to mediate repression of both viral replication and transcription.
CC       {ECO:0000250|UniProtKB:P0DKA0}.
CC   -!- SUBCELLULAR LOCATION: Host nucleus {ECO:0000250|UniProtKB:P0DKA0}.
CC   -!- SIMILARITY: Belongs to the papillomaviridae E8^E2C protein family.
CC       {ECO:0000305}.
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DR   EMBL; M17463; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   SMR; P0DOD3; -.
DR   Proteomes; UP000009252; Genome.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:InterPro.
DR   Gene3D; 3.30.70.330; -; 1.
DR   InterPro; IPR035975; E2/EBNA1_C_sf.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR000427; Papillomavirus_E2_C.
DR   Pfam; PF00511; PPV_E2_C; 1.
DR   SUPFAM; SSF54957; SSF54957; 1.
PE   3: Inferred from homology;
KW   Host nucleus; Reference proteome.
FT   CHAIN           1..323
FT                   /note="Protein E8^E2C"
FT                   /id="PRO_0000438758"
FT   REGION          1..233
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        12..53
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        61..93
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        94..123
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        139..171
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   323 AA;  35515 MW;  E2239DB368EEDA92 CRC64;
     MKLKMLLLSS TPPGSPGGQA DTNTTPATPT TSTTAVDSTS RQLTTSKQPQ QTETRGRRYG
     RRPSSKSRRS QTQQRRSRSR HRSRSRSRSR SKSQTHTTRS TTRSRSTSLT KTRALTSRSR
     SRGRSPTTCR RGGGRSPRRR SRSPSTSSSC TTQRSQRARA ESSTTRGARG SRGSRGGSRG
     GRGRRRGRSS SSSSPAHKRS RGGSAKLRGV SPGEVGGSLR SVSSKHTGRL GRLLEEARDP
     PVIIVKGAAN TLKCFRNRAK IKYMGLFRSF STTWSWVAGD GTERLGRPRM LISFSSYTQR
     RDFDEAVRYP KGVDKAYGNL DSL