ID   VE8E2_HPV08             Reviewed;         307 AA.
AC   P0DOD2;
DT   18-JAN-2017, integrated into UniProtKB/Swiss-Prot.
DT   18-JAN-2017, sequence version 1.
DT   02-JUN-2021, entry version 19.
DE   RecName: Full=Protein E8^E2C;
OS   Human papillomavirus type 8.
OC   Viruses; Monodnaviria; Shotokuvirae; Cossaviricota; Papovaviricetes;
OC   Zurhausenvirales; Papillomaviridae; Firstpapillomavirinae;
OC   Betapapillomavirus.
OX   NCBI_TaxID=10579;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=3009874; DOI=10.1128/jvi.58.2.626-634.1986;
RA   Fuchs P.G., Iftner T., Weninger J., Pfister H.;
RT   "Epidermodysplasia verruciformis-associated human papillomavirus 8: genomic
RT   sequence and comparative analysis.";
RL   J. Virol. 58:626-634(1986).
CC   -!- FUNCTION: Plays a role in limiting the replication of viral DNA in
CC       keratinocytes. Recruits the host NCoR/SMRT complex to viral replication
CC       foci to mediate repression of both viral replication and transcription.
CC       {ECO:0000250|UniProtKB:P0DKA0}.
CC   -!- SUBCELLULAR LOCATION: Host nucleus {ECO:0000250|UniProtKB:P0DKA0}.
CC   -!- SIMILARITY: Belongs to the papillomaviridae E8^E2C protein family.
CC       {ECO:0000305}.
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DR   EMBL; M12737; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   SMR; P0DOD2; -.
DR   Proteomes; UP000009103; Genome.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:InterPro.
DR   Gene3D; 3.30.70.330; -; 1.
DR   InterPro; IPR035975; E2/EBNA1_C_sf.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR000427; Papillomavirus_E2_C.
DR   Pfam; PF00511; PPV_E2_C; 1.
DR   SUPFAM; SSF54957; SSF54957; 1.
PE   3: Inferred from homology;
KW   Host nucleus.
FT   CHAIN           1..307
FT                   /note="Protein E8^E2C"
FT                   /id="PRO_0000438757"
FT   REGION          1..208
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        12..51
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        52..69
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        70..86
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        87..111
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        112..139
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        140..154
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   307 AA;  34362 MW;  07DBB2B2E3465279 CRC64;
     MKLKMFLMSS TPPGSPPGQA DTDTAAKTPT TSADSTSRQQ RSPAKQPQQT ETKGRRYGRR
     PSSRTRPQKE QRRSRSRHRT RSRSRSLSRV RAVGSTTVSR SRSSSLTKAV RPRSRSRSRG
     RATATSRRRA GRGSPRRRRS TSRSPSTNTF KRSQRGGGRR GRGRGSRGRR ERSSSTSPTP
     TKRSRGESSR LRGVSPSEVG RSVQSVSAKH TGRLGRLLDE AIDPPVILVR GEANTLKCFR
     NRARVRYRGL FKYFSTTWSW VAGDSTERLG RSRMLILFTS AGQRKDFDET VKYPKGVDTS
     YGNLDSL