ID   VE8E2_HPV16             Reviewed;         177 AA.
AC   P0DKA0;
DT   18-JAN-2017, integrated into UniProtKB/Swiss-Prot.
DT   18-JAN-2017, sequence version 1.
DT   12-AUG-2020, entry version 17.
DE   RecName: Full=Protein E8^E2C;
OS   Human papillomavirus type 16.
OC   Viruses; Monodnaviria; Shotokuvirae; Cossaviricota; Papovaviricetes;
OC   Zurhausenvirales; Papillomaviridae; Firstpapillomavirinae;
OC   Alphapapillomavirus.
OX   NCBI_TaxID=333760;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2990099; DOI=10.1016/0042-6822(85)90214-4;
RA   Seedorf K., Krammer G., Durst M., Suhai S., Rowekamp W.G.;
RT   "Human papillomavirus type 16 DNA sequence.";
RL   Virology 145:181-185(1985).
RN   [2]
RP   FUNCTION.
RX   PubMed=24198405; DOI=10.1128/jvi.02296-13;
RA   Straub E., Dreer M., Fertey J., Iftner T., Stubenrauch F.;
RT   "The viral E8^E2C repressor limits productive replication of human
RT   papillomavirus 16.";
RL   J. Virol. 88:937-947(2014).
RN   [3]
RP   SUBCELLULAR LOCATION, FUNCTION, AND INTERACTION WITH HOST GPS2; HDAC3;
RP   NCOR1; NCOR2; TBL1X AND TBLR1.
RX   PubMed=27064408; DOI=10.1371/journal.ppat.1005556;
RA   Dreer M., Fertey J., van de Poel S., Straub E., Madlung J., Macek B.,
RA   Iftner T., Stubenrauch F.;
RT   "Interaction of NCOR/SMRT repressor complexes with Papillomavirus E8^E2C
RT   proteins inhibits viral replication.";
RL   PLoS Pathog. 12:E1005556-E1005556(2016).
CC   -!- FUNCTION: Plays a role in limiting the replication of viral DNA in
CC       keratinocytes. Recruits the host NCoR/SMRT complex to viral replication
CC       foci to mediate repression of both viral replication and transcription.
CC       {ECO:0000269|PubMed:27064408}.
CC   -!- SUBUNIT: Interacts with host NCoR/SMRT components GPS2, HDAC3, NCOR1,
CC       NCOR1, TBL1X and TBLR1. {ECO:0000269|PubMed:27064408}.
CC   -!- SUBCELLULAR LOCATION: Host nucleus {ECO:0000269|PubMed:27064408}.
CC   -!- SIMILARITY: Belongs to the papillomaviridae E8^E2C protein family.
CC       {ECO:0000305}.
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DR   EMBL; K02718; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   SMR; P0DKA0; -.
DR   Proteomes; UP000009251; Genome.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:InterPro.
DR   Gene3D; 3.30.70.330; -; 1.
DR   InterPro; IPR035975; E2/EBNA1_C_sf.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR000427; Papillomavirus_E2_C.
DR   Pfam; PF00511; PPV_E2_C; 1.
DR   SUPFAM; SSF54957; SSF54957; 1.
PE   1: Evidence at protein level;
KW   Host nucleus; Reference proteome.
FT   CHAIN           1..177
FT                   /note="Protein E8^E2C"
FT                   /id="PRO_0000438740"
SQ   SEQUENCE   177 AA;  19925 MW;  A361364C880D5D78 CRC64;
     MAILKWKLSR CYSSNEVSSP EIIRQHLANH PAATHTKAVA LGTEETQTTI QRPRSEPDTG
     NPCHTTKLLH RDSVDSAPIL TAFNSSHKGR INCNSNTTPI VHLKGDANTL KCLRYRFKKH
     CTLYTAVSST WHWTGHNVKH KSAIVTLTYD SEWQRDQFLS QVKIPKTITV STGFMSI