ID   VE8E2_HPV28             Reviewed;         176 AA.
AC   P0DKA4;
DT   18-JAN-2017, integrated into UniProtKB/Swiss-Prot.
DT   18-JAN-2017, sequence version 1.
DT   03-AUG-2022, entry version 24.
DE   RecName: Full=Protein E8^E2C;
OS   Human papillomavirus 28.
OC   Viruses; Monodnaviria; Shotokuvirae; Cossaviricota; Papovaviricetes;
OC   Zurhausenvirales; Papillomaviridae; Firstpapillomavirinae;
OC   Alphapapillomavirus.
OX   NCBI_TaxID=37111;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Delius H.;
RL   Submitted (OCT-1995) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays a role in limiting the replication of viral DNA in
CC       keratinocytes. Recruits the host NCoR/SMRT complex to viral replication
CC       foci to mediate repression of both viral replication and transcription.
CC       {ECO:0000250|UniProtKB:P0DKA0}.
CC   -!- SUBCELLULAR LOCATION: Host nucleus {ECO:0000250|UniProtKB:P0DKA0}.
CC   -!- SIMILARITY: Belongs to the papillomaviridae E8^E2C protein family.
CC       {ECO:0000305}.
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DR   EMBL; U31783; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   SMR; P0DKA4; -.
DR   Proteomes; UP000009158; Genome.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:InterPro.
DR   Gene3D; 3.30.70.330; -; 1.
DR   InterPro; IPR035975; E2/EBNA1_C_sf.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR000427; Papillomavirus_E2_C.
DR   Pfam; PF00511; PPV_E2_C; 1.
DR   SUPFAM; SSF54957; SSF54957; 1.
PE   3: Inferred from homology;
KW   Host nucleus.
FT   CHAIN           1..176
FT                   /note="Protein E8^E2C"
FT                   /id="PRO_0000438744"
FT   REGION          1..70
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        18..70
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   176 AA;  19846 MW;  94C1B8BFBB40F9E4 CRC64;
     MAKHSTREIP AAGPLCTGDT TKASTETSVG ATEGPQQKRQ RLETLNWEQQ QRQYPQTPST
     QTTERASQPL DVTRTSDCDT TCPYTVGHPS DPDCAPVVHL KGDPNCLKCF RYRLHKGKRK
     LYCKTSSTWR WSCESENQAA FVTIWYTSYS QRNEFLSTVK VPPGIQVILG HMSMFV