ID   VE8E2_HPV47             Reviewed;         315 AA.
AC   P0DOD5;
DT   18-JAN-2017, integrated into UniProtKB/Swiss-Prot.
DT   18-JAN-2017, sequence version 1.
DT   02-JUN-2021, entry version 20.
DE   RecName: Full=Protein E8^E2C;
OS   Human papillomavirus 47.
OC   Viruses; Monodnaviria; Shotokuvirae; Cossaviricota; Papovaviricetes;
OC   Zurhausenvirales; Papillomaviridae; Firstpapillomavirinae;
OC   Betapapillomavirus.
OX   NCBI_TaxID=10594;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2162112; DOI=10.1016/0042-6822(90)90500-q;
RA   Kiyono T., Adachi A., Ishibashi M.;
RT   "Genome organization and taxonomic position of human papillomavirus type 47
RT   inferred from its DNA sequence.";
RL   Virology 177:401-405(1990).
CC   -!- FUNCTION: Plays a role in limiting the replication of viral DNA in
CC       keratinocytes. Recruits the host NCoR/SMRT complex to viral replication
CC       foci to mediate repression of both viral replication and transcription.
CC       {ECO:0000250|UniProtKB:P0DKA0}.
CC   -!- SUBCELLULAR LOCATION: Host nucleus {ECO:0000250|UniProtKB:P0DKA0}.
CC   -!- SIMILARITY: Belongs to the papillomaviridae E8^E2C protein family.
CC       {ECO:0000305}.
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DR   EMBL; M32305; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   SMR; P0DOD5; -.
DR   Proteomes; UP000008697; Genome.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:InterPro.
DR   Gene3D; 3.30.70.330; -; 1.
DR   InterPro; IPR035975; E2/EBNA1_C_sf.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR000427; Papillomavirus_E2_C.
DR   Pfam; PF00511; PPV_E2_C; 1.
DR   SUPFAM; SSF54957; SSF54957; 1.
PE   3: Inferred from homology;
KW   Host nucleus.
FT   CHAIN           1..315
FT                   /note="Protein E8^E2C"
FT                   /id="PRO_0000438760"
FT   REGION          1..215
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        12..53
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        61..83
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        84..107
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        117..151
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        170..200
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   315 AA;  35414 MW;  695AD33408CBB124 CRC64;
     MKLKMLLLSS TPPGSPGGQT DPDTSSKTPT TTTAATDTSP RRQSINKQSQ QTETKRRGYG
     RRPSSRTRRP QTHQRRSRSR SRSRSSSQTH SSTTTTTTTY RSRSTSLNKT RARSRSRSTS
     RSTSTTSRRG GRGSSTRQRS RSPSTYTSKR SREGNTRGRG RGRQGRAGSS GGREQRRRRR
     SFSTSPDSSK RVRRESPKYR GVSPSEVGKQ LRSVGAKHSG RLGRLLEEAR DPPVILVRGD
     ANTLKCFRNR ARNKYRGLFR SFSTTFSWVA GDSIERLGRS RMLISFSCLT QRRDFDDAVK
     YPKGVEWSYG SLDSL